Reduction of pain on injection of propofol using meperidine and remifentanil

Başaranoğlu, Gökçen; Erden, Veysel; Delatioğlu, Hamdi; Saitoglu, Leyla

doi:10.1017/s0265021505231502

Cited by 34 publications

(32 citation statements)

References 5 publications

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“…Ba sed on the pre vi o us li te ra ture, 8,19 we ex pec ted a 40% in ci den ce of pro po fol pain af ter re mi fen ta nil in fu si on and mi ni mum 23 pa ti ents per gro up wo uld be re qu i red to dec re a se this in ci den ce to 5% by ad ding li do ca i ne (po wer 80%, α= 0.05).…”

Section: Ma Te Ri Al and Met Hodsmentioning

confidence: 89%

“…1,2 Many stra te gi es ha ve be en used to re du ce the in jec ti on pa in of pro po fol inc lu ding the in jec ti on spe ed and the car ri er fluid, 3,4 its di lu ti on, 5,6 pret re at ment with al fen ta nil 7 or re mi fen ta nil 8 and the in jec ti on of li do ca i ne be fo re pro po fol 9,10 or mi xing the two drugs be fo re in jec tion. [11][12][13] Re cently, two stu di es ha ve shown that com bina ti on of re mi fen ta nil and li do ca i ne comp le tely abo lis hes mo de ra te and se ve re pa in du ring the injec ti on of 1% pro po fol when com pa red to each drug used alo ne.…”

Section: The Effect Of Lidocaine On Injection Pain Of Different Propomentioning

confidence: 99%

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The Effect of Lidocaine on Injection Pain of Different Propofol Concentrations in Patients Receiving Remifentanil

Öztekin¹,

Olguner²,

Akan³

et al. 2011

Turkiye Klinikleri J Med Sci

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A AB BS S T TR RA AC CT T O Ob b j je ec c t ti i v ve e: : The ef fec ti vity of re mi fen ta nil and li do ca i ne com bi na ti on on the in jec tion pa in with 1% pro po fol was re por ted pre vi o usly. Ho we ver, this fin ding has not be en in ves ti gated with dif fe rent pro po fol con cen tra ti ons. In this pros pec ti ve, ran do mi zed, do ub le-blind tri al, we ai med to com pa re the ef fect of li do ca i ne on the in jec ti on pa in of 1% or 2% pro po fol in pa tients re ce i ving re mi fen ta nil. M Ma a t te e r ri i a al l a an nd d M Me et t h ho od ds s: : One hun dred pa ti ents un der go ing ear-no sethro at sur gery we re ran domly as sig ned into fo ur gro ups (n= 25 each). Fol lo wing 0.5 µg/kg/min re mi fen ta nil, pa ti ents in Gro up 1 and Gro up 2 re ce i ved 1 mg.kg -1 1% or 2% pro po fol the mi xed with 2 mL of sa li ne, res pec ti vely. Pa ti ents in Gro up 3 and Gro up 4 re ce i ved 1 mg.kg -1 1% or 2% pro po fol mi xed with 2 mL of 2% li do ca i ne af ter 0.5 µg kg -1 min -1 re mi fen ta nil. Pa in du ring the injec ti on of pro po fol was as ses sed on a fo ur-po int sca le (0= no ne, 1= mild, 2= mo de ra te, 3= se ve re) R Re e s su ul lt ts s: : The in ci den ce of no ne-mild pa in on in jec ti on of 1% pro po fol was sig ni fi cantly lo wer in Gro up 1 (56%) com pa red to Gro up 3 (100%) (p= 0.00017). This fin ding was al so seen bet we en Gro up 2 (36%) and Gro up 4 (72%) (p= 0.010). Ho we ver, the num ber of pa ti ents suf fe ring from the in jec ti on pa in was sig ni fi cantly gre a ter in Gro up 4 com pa red to Gro up 3 (p= 0.004). C Co on nc c l lu u s si i o on n: : Li do ca i ne 2% 2 mL mi xed with pro po fol comp le tely abo lis hed mo de ra te-se ve re pa in in du ced by 1% pro po fol in pa ti ents who we re gi ven 0.5 µg/kg/min re mi fen ta nil. Ho we ver, so me pa ti ents still suf fe red from in jec ti on pa in ca u sed by 2% pro po fol in spi te of the com bi ned ef fect of li do ca i ne and re mi fen ta nil. K Ke ey y W Wo or rd ds s: : Propofol; injections, intravenous; pain; remifentanil; lidocaine Ö ÖZ ZE ET T A Am ma aç ç: : Yüzde 1'lik pro po fo le bağ lı en jek si yon ağ rı sı üze rin de re mi fen ta nil ve li do ka in kombi nas yo nu nun et ki si da ha ön ce ça lı şıl mış tır. An cak bu bul gu fark lı pro po fol kon san tras yon la rı ile araş tı rıl ma mış tır. Bu pros pek tif, ran do mi ze, çift-kör ça lış ma da re mi fen ta nil alan has ta lar da li do kai nin %1'lik ve ya %2'lik pro po fol kon san tras yon la rı nın en jek si yon ağ rı sı üze rin de ki et ki si ni kar şı -laş tır ma yı amaç la dık. G Ge e r re eç ç v ve e Y Yö ön n t te em m l le er r: : Ku lak-bu run-bo ğaz cer ra hi si ya pı lan yüz has ta ran do mi ze ola rak dört gru ba ay rıl dı (n= 25, her bi ri). Grup 1 ve 2'de ki has ta la ra 0.5 µg/kg/dk re mifen ta ni li ta ki ben ay rı ay rı 1 mg/kg %1'lik pro po fol ve ya %2'lik pro po fo lün 2 mL se rum fiz yo lo jik ile ka rı şı mı uy gu lan dı. Grup 3 ve Grup 4'te ki has ta la ra 0.5 µg/kg/dk re mi fen ta ni li ta ki ben 1 mg/kg %1'lik ...

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Section: Ma Te Ri Al and Met Hodsmentioning

confidence: 89%

Section: The Effect Of Lidocaine On Injection Pain Of Different Propomentioning

confidence: 99%

The Effect of Lidocaine on Injection Pain of Different Propofol Concentrations in Patients Receiving Remifentanil

Öztekin¹,

Olguner²,

Akan³

et al. 2011

Turkiye Klinikleri J Med Sci

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“…Fentanyl, sufentanil and remifentanil appear to be a very titratable opioid providing profound intraoperative analgesia [28][29][30] . In the report by Han 15 , combination of a pretreatment with remifentanil and premixture of lidocaine and microemulsion propofol displayed effective function in reducing the incidence of pain on an injection of microemulsion propofol 31 .…”

Section: Comparison Of Anesthesia Effect Of Propofol Via Different Comentioning

confidence: 99%

Comparing the pain of propofol via different combinations of fentanyl, sufentanil or remifentanil in gastrointestinal endoscopy

2014

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“…The use of remifentanil to prevent the pain of propofol injection has been studied by several investigators [18,19]. Remifentanil is an opioid of the phenylpiperidine group and could have a local anesthetic effect on nerves.…”

mentioning

confidence: 99%

“…Basaranoglu and colleagues [19] used remifentanil 1 μg/kg/min before propofol, and the incidence of propofol injection pain decreased from 32% to 44%. Considering these result, a dose-dependent effect of remifentanil in attenuating propofol injection pain is suspected.…”

mentioning

confidence: 99%