Reduction of pertechnetate-99m ion by hydrochloric acid

Abstracts. Second international symposium on radiopharmaceuticals chemistry

“…This i n s t a b i l i t y a t n e u t r a l (and p h y s i o l o g i c a l ) pH has precluded a s t u d y of t h e b i o l o g i c a l p r o p e r t i e s of t h i s radiopharmaceutical. : been a p p l i e d t o t h e s y n t h e s i s of laFDG which we r e p o r t e d earlier (3,4). t i o n p o s i t i o n s i n glucose 3 appears t h e most a t t r a c t i v e (Table 1 ) ( 2 , 3 ) .…”

“…iii Structural analogues of the natural components which follow all or part of the chosen pathway, such as (Se-75)selenomethionine, (~-18)6-fluorotryptophan for pancreas scanning (3) or 19-iodocholesterol(4) (Se-75) 6-methyl-seleno-methyl "or cholesterol for adrenal studies.…”

“…The effects of radionuclide incorporation on the biochemical behaviour of the selected compound may be important considerations. For example halogen-substituted amino acids or nucleotides may not be incorporated into protein or DNA to the same extent as their nonhalogenated analogues (3,7). Such differences in behaviour are of especial significance when labelling is achieved by complex formation between a biochemical substrate and a cationic radionuclide.…”

“…4 AGENTS FOR THE ARMAMENTARIUM OF REGIONAL METABOLIC MEASUREMENT I N VIVO (1). I n t e r e s t i n l a b e l e d a n a l o g s o f 2-DG which could b e used t o measure r e g i o n a l b r a i n glucose metabolism w a s s t i m u l a t e d by t h e work of Sokoloff, Reiv-ich and coworkers (2) and l e d t o t h e development o f 18F-2deoxy-2-fluoro-D-glucose (3,4).…”

“…t i o n p o s i t i o n s i n glucose 3 appears t h e most a t t r a c t i v e (Table 1 ) ( 2 , 3 ) . F l u o r i n a t i o n a t C-6 p r e v e n t s phosphorylation, a t C-5 p r e v e n t s r i n g c l o s u r e and 1and 4-fluoro-deoxy-glucoses a r e r a p i d l y hydrolyzed i n v i v o (3). (1) Kuhl D .…”