2023
DOI: 10.3390/nu15071713
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Reduction of Plasma BCAAs following Roux-en-Y Gastric Bypass Surgery Is Primarily Mediated by FGF21

Abstract: Type 2 diabetes (T2D) is a challenging health concern worldwide. A lifestyle intervention to treat T2D is difficult to adhere, and the effectiveness of approved medications such as metformin, thiazolidinediones (TZDs), and sulfonylureas are suboptimal. On the other hand, bariatric procedures such as Roux-en-Y gastric bypass (RYGB) are being recognized for their remarkable ability to achieve diabetes remission, although the underlying mechanism is not clear. Recent evidence points to branched-chain amino acids … Show more

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Cited by 3 publications
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“…Acting as a systematic peptide hormone, FGF21 plays a significant role in regulating energy balance, as well as maintaining glucose and lipid homeostasis. Additionally, there is a strong correlation between FGF21 levels and decreased circulating levels of BCAAs ( Jiang et al, 2015 ; Karusheva et al, 2019 ; Yu et al, 2021 ; Shah et al, 2023 ). These findings have reignited interest in increasing energy expenditure by CE and BAT activation to combat obesity and its associated metabolic complications, including diabetes, dyslipidemia, and cardiovascular diseases in adult humans ( Kajimura and Saito, 2014 ; Becher et al, 2021 ).…”
Section: Introductionmentioning
confidence: 99%
“…Acting as a systematic peptide hormone, FGF21 plays a significant role in regulating energy balance, as well as maintaining glucose and lipid homeostasis. Additionally, there is a strong correlation between FGF21 levels and decreased circulating levels of BCAAs ( Jiang et al, 2015 ; Karusheva et al, 2019 ; Yu et al, 2021 ; Shah et al, 2023 ). These findings have reignited interest in increasing energy expenditure by CE and BAT activation to combat obesity and its associated metabolic complications, including diabetes, dyslipidemia, and cardiovascular diseases in adult humans ( Kajimura and Saito, 2014 ; Becher et al, 2021 ).…”
Section: Introductionmentioning
confidence: 99%