Reduction of plasma volume after storage of platelets in CP2D

Rock, Gail; Haddad, Sheila; Poon, Annette; Romans, Robert A.; Sparling, Catherine; Louis, Patrick St.; Berger, Robert

doi:10.1046/j.1537-2995.1998.38398222867.x

Cited by 11 publications

(17 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…No difference was found between collagen-induced activation before and after plasma depletion. Our results are similar to the findings of Rock et al (1), who demonstrated an increased CD62 expression in volume-reduced PCs, although this change did not reach significance.…”

Section: Discussionsupporting

confidence: 90%

See 1 more Smart Citation

The Functional Integrity of Platelets in Volume-Reduced Platelet Concentrates

Schoenfeld¹,

Muhm²,

Doepfmer³

et al. 2005

Anesthesia & Analgesia

View full text Add to dashboard Cite

Premature and low-birth-weight infants usually require small-volume platelet transfusions to treat thrombocytopenia. Also, infants undergoing open-heart surgery with extracorporeal circulation and with compromised cardiac function are at risk for excessive intravascular volume. The small-volume platelet substitution can be achieved by dispensing an aliquot from the unit of a standard single-donor platelet concentrate (PC). Alternatively, there is an indication for volume reduction of PCs to maximize the number of platelets transfused in the smallest possible volume. We determined the spontaneous and induced activation of platelets before and after volume reduction in 20 consecutive single-donor-apheresis PCs. After a mean storage time of 2 days, the PCs were plasma-depleted by centrifugation. Spontaneous, adenosine diphosphate (ADP)-induced, and collagen-induced activation were determined by flow cytometry. Furthermore, ADP- and collagen-induced aggregation were measured. A total of 33.8% of platelets in standard PCs were activated spontaneously. Volume reduction of PCs led to a mild but significant increase of spontaneous activation of platelets (43.2%). Additionally, volume reduction resulted in an impaired ADP-induced aggregability of platelets, whereas collagen induction was unaffected. Transfusion of volume-reduced PCs is an effective alternative to use of standard PCs in patients at frequent risk for excessive intravascular volume, because equal volumes increase the platelet count twice as effectively.

show abstract

Section: Discussionsupporting

confidence: 90%

“…However, Rock et al (1) suggest that additional centrifugation for plasma removal could further affect platelets that have already been altered by storage. The functional integrity of platelets in volumereduced PCs has been studied only infrequently in vitro (1,6 -11).…”

mentioning

confidence: 99%

The Functional Integrity of Platelets in Volume-Reduced Platelet Concentrates

Schoenfeld¹,

Muhm²,

Doepfmer³

et al. 2005

Anesthesia & Analgesia

View full text Add to dashboard Cite

show abstract

“…Similarly, at 7 days of storage, the results of all four tests were significantly different for the two methods of storage (Table 2). When the results were compared to the literature's reference ranges for 5‐ and 7‐day storage, however, they were comparable 2‐4,19,21‐25 . pH values for both types of storage on both Day 5 and Day 7 were all above pH 6.5 (Fig.…”

Section: Resultsmentioning

confidence: 74%

“…Laboratory tests were performed to determine PLT and WBC counts, metabolic activity, shape change and morphology, PLT activation and/or secretion status, and presence of bacterial contamination 10‐14 . A literature search was also performed to identify studies that had reported ranges for the various test results performed on PLT products stored for 5 and/or 7 days 15‐25 . The reported values in these studies were used as a reference range for comparative purposes.…”

Section: Methodsmentioning

confidence: 99%

In vitro evaluation of prestorage pooled leukoreduced whole blood–derived platelets stored for up to 7 days

Heddle

Barty²,

Sigouin³

et al. 2005

Transfusion

View full text Add to dashboard Cite

show abstract

“…94 There is no standard method for preparing volume-reduced platelet concentrates. [80][81][95][96][97][98][99] If secondary volume reduction of platelet components is necessary, the authors recommend the method of Moroff and colleagues. [80][81][95][96][97][98][99] If secondary volume reduction of platelet components is necessary, the authors recommend the method of Moroff and colleagues.…”

Section: Secondary Volume Reductionmentioning

confidence: 99%