2004
DOI: 10.1016/s0140-6736(04)17139-0
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Reduction of postoperative chemotherapy in children with stage I intermediate-risk and anaplastic Wilms' tumour (SIOP 93-01 trial): a randomised controlled trial

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Cited by 194 publications
(146 citation statements)
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“…17 All other countries continued the well established SIOP approach of starting preoperative chemotherapy on the basis of clinical and imaging characteristics consistent with a diagnosis of Wilms' tumour, combined with measuring urinary catecholamines to exclude neuroblastoma, and reserving biopsy for cases with diagnostic dilemma. 2,18,19 Three-dimensional tumour volume was recorded at diagnosis and after completion of preoperative chemotherapy, according to whichever imaging method had been applied (ultrasonography, CT scan, or MRI scan). The calculated volume showed close correlation between methods (appendix).…”
Section: Methodsmentioning
confidence: 99%
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“…17 All other countries continued the well established SIOP approach of starting preoperative chemotherapy on the basis of clinical and imaging characteristics consistent with a diagnosis of Wilms' tumour, combined with measuring urinary catecholamines to exclude neuroblastoma, and reserving biopsy for cases with diagnostic dilemma. 2,18,19 Three-dimensional tumour volume was recorded at diagnosis and after completion of preoperative chemotherapy, according to whichever imaging method had been applied (ultrasonography, CT scan, or MRI scan). The calculated volume showed close correlation between methods (appendix).…”
Section: Methodsmentioning
confidence: 99%
“…[7][8][9] Survival from Wilms' tumour has been increasing over the past 40 years, while, paradoxically, the overall duration and intensity of treatment has been decreasing for most patients. 2,4 This fi nding suggests that further treatment reductions could be possible for many patients.…”
Section: Introductionmentioning
confidence: 96%
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“…Since the first SIOP protocol started in 1971, treatment intensity has been successfully reduced for the majority of patients with Wilms tumours, and survival has risen to 90% 2,[6][7][8][9][10] . Consequently, the identification of additional predictive and prognostic factors is increasingly important to improve the stratification of patients according to their individual risk.…”
Section: Treatment Recommendationsmentioning
confidence: 99%
“…Similar to the SIOP−2001 protocol, the UMBRELLA protocol continues to recommend preoperative actinomycin D and vincristine for patients newly diagnosed with Wilms tumour aged ≥6 months, based on results of previous SIOP trials that showed tumour downstaging using this regimen 2,6,8,9,14,17 . This benefit was also independently observed in the randomized, controlled UKW3 trial conducted by the UK Children's Cancer and Leukaemia Group (UKCCLG, previously known as the UK Children's Cancer Study Group) 18 .…”
Section: Treatment Recommendationsmentioning
confidence: 99%