Reduction of postoperative facial swelling by low-dose methylprednisolone: An experimental study

Milles, Maano; Desjardins, Paul J.

doi:10.1016/s0278-2391(10)80041-2

Cited by 73 publications

(57 citation statements)

References 17 publications

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“…It has shown that there is more reduction in pain and trismus following submucosal infiltration of dexamethasone or methylprednisolone rather than control group [13]. According to Milles' study trismus and need of taking extra analgesic medications were not affected by administration of low-dose methylprednisolone [14]; whereas Baxendale et al [15] observed the elimination of analgesic intake by administering pre-operative dexamethasone while trismus was not affected. Various results in pain and mouth opening were found by Shin et al [16] while Bamgbose et al [17] observed better results by administering dexamethasone and diclofenac K rather than diclofenac K alone.…”

Section: Discussionmentioning

confidence: 99%

A Comparative Study of the Effect of Prednisolone and Celecoxib on MMO (Maximum Mouth Opening) and Pain Following Removal of Impacted Mandibular Third Molars

Moghaddamnia

Nosrati

Mehdizadeh

et al. 2012

J. Maxillofac. Oral Surg.

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Objective The purpose of this study was to compare the effects of prednisolone and celecoxib on pain and maximum mouth opening (MMO) after surgical removal of mandibular third molars. Methods and Materials This double-blind clinical study was conducted upon 60 subjects. These patients received 4 tablets of either 100 mg celecocxib or 5 mg prednisolone: one tablet before surgery and the rest for every 8 h postoperation. The subjects were asked to take acetaminophen codeine as rescue dose. Interincisal distance of upper and lower central teeth and pain measurements (according to Visual Analogue Scale) were taken before surgery, 24 h, 48 h and 7 days after surgery. Results Average pain intensity in 24 h after surgery in patients receiving celecoxib was 3.6 ± 2.5 with significant difference to the other group (p = 0.041), but in subsequent evaluations prednisolone group reported less pain intensity, but the differences were not significant. MMO in 48 h after surgery was lower in prednisolone group (p = 0.640) and in further evaluations the groups were almost similar. Analyzing the data revealed no significant difference between groups in MMO. Conclusion According to this study there is no significant difference in the effects of prednisolone or celecoxib upon MMO, while celecoxib had better results for pain relief in 24 h after surgery in comparison to prednisolone.

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Section: Discussionmentioning

confidence: 99%

A Comparative Study of the Effect of Prednisolone and Celecoxib on MMO (Maximum Mouth Opening) and Pain Following Removal of Impacted Mandibular Third Molars

Moghaddamnia

Nosrati

Mehdizadeh

et al. 2012

J. Maxillofac. Oral Surg.

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“…A multiple dose regimen was never adopted to test the clinical efficacy of valdecoxib after lower third molar removal. This approach seems more realistic from a clinical point of view than a single-dose regimen, since maximum facial swelling is expected to occur 48 h after the surgical procedure (34), although it may increase on the third postoperative day (35). Moreover, pain reaches a peak as the anesthetic wears off and the full inflammatory response to surgery evolves (27), and may last for three to five days after the procedure (36).…”

Section: Discussionmentioning

confidence: 99%

The selective and non-selective cyclooxygenase inhibitors valdecoxib and piroxicam induce the same postoperative analgesia and control of trismus and swelling after lower third molar removal

Benetello

Sakamoto

Giglio

et al. 2007

Braz J Med Biol Res

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We compared the clinical efficacy of orally administered valdecoxib and piroxicam for the prevention of pain, trismus and swelling after removal of horizontally and totally intrabony impacted lower third molars. Twenty-five patients were scheduled to undergo removal of symmetrically positioned lower third molars in two separate appointments. Valdecoxib (40 mg) or piroxicam (20 mg) was administered in a double-blind, randomized and crossed manner for 4 days after the surgical procedures. Objective and subjective parameters were recorded for comparison of postoperative courses. Both agents were effective for postoperative pain relief (N = 19). There was a similar mouth opening at suture removal compared with the preoperative values (86.14 ± 4.36 and 93.12 ± 3.70% of the initial measure for valdecoxib and piroxicam, respectively; ANOVA). There was no significant difference regarding the total amount of rescue medication taken by the patients treated with valdecoxib or piroxicam (173.08 ± 91.21 and 461.54 ± 199.85 mg, respectively; Wilcoxon test). There were no significant differences concerning the swelling observed on the second postoperative day compared to baseline measures (6.15 ± 1.84 and 8.46 ± 2.04 mm for valdecoxib and piroxicam, respectively; ANOVA) or on the seventh postoperative day (1.69 ± 1.61 and 2.23 ± 2.09 mm for valdecoxib and piroxicam, respectively; ANOVA). The cyclooxygenase-2 selective inhibitor valdecoxib is as effective as the non-selective cyclooxygenase inhibitor piroxicam for pain, trismus and swelling control after removal of horizontally and totally intrabony impacted lower third molars.

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“…The surgical extraction of impacted mandibular third molars often causes swelling of facial soft tissues, trismus and pain. 17 These post-operative sequelae are quite annoying to the patient and would affect their quality of life by delaying the period of recovery. These complications are attributed to the inflammation produced as a result of surgical trauma.…”

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confidence: 99%

“…Milles et al 17 and Stefen et al 18 found that less number of analgesic tablets were taken by patients in steroid group when compared to placebo. Few other investigators using visual analogue scale, found that the pain scores were significantly higher in placebo on 2 nd post-operative day and the scores returned to the preoperative scores by 7 th post-operative day in both the groups.…”

mentioning

confidence: 98%

A Prospective Randomised Double Blind Study Evaluating the Efficacy of Intra Venous Methylprednisolone in Third Molar Surgery.

Kumar¹,

Bhushan²,

Navatha³

et al. 2017

IJAR

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Texture.Purpose: To evaluate the efficacy of 40 mg pre-operative and 80 mg post-operative doses of intravenous methylprednisolone (Solumedrol) in the reduction of post-operative complication after surgical removal of impacted mandibular third molars. Materials and methods: A prospective randomised double blind study was carried out in The Department of Oral and Maxillofacial surgery, GITAM Dental College and Hospital, Visakhapatnam On fifty patients with impacted mandibular third molars randomly divided into two groups of twenty five patients each after obtaining the ethical committee approval. Parameters taken for consideration are swelling, pain and trismus pre-operatively, immediate post operative, 2 nd and 7 th post operative days. WBC count on pre operative and 7 th post op day. The study solution was administered intravenously just before administration of local anesthesia. Post operative dose of the drug was given 6 hours after the pre operative dose. Results: Significant difference was observed between placebo and steroid groups with respect to pain, swelling and mouth opening from pre-operative to 2 nd day. Non-significant difference was observed between placebo and steroid groups with respect to WBC counts (cells/mm3) at pre-operative, 7 th day and difference of pre-operative to 7 th day at 5% level of significance (p>0.05).

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Reduction of postoperative facial swelling by low-dose methylprednisolone: An experimental study

Cited by 73 publications

References 17 publications

A Comparative Study of the Effect of Prednisolone and Celecoxib on MMO (Maximum Mouth Opening) and Pain Following Removal of Impacted Mandibular Third Molars

A Comparative Study of the Effect of Prednisolone and Celecoxib on MMO (Maximum Mouth Opening) and Pain Following Removal of Impacted Mandibular Third Molars

The selective and non-selective cyclooxygenase inhibitors valdecoxib and piroxicam induce the same postoperative analgesia and control of trismus and swelling after lower third molar removal

A Prospective Randomised Double Blind Study Evaluating the Efficacy of Intra Venous Methylprednisolone in Third Molar Surgery.

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