Reduction of postoperative pain after lumbar microdiscectomy with DuraSeal Xact Adhesion Barrier and Sealant System

Fransen, Patrick

doi:10.1016/j.spinee.2010.05.001

Cited by 27 publications

(25 citation statements)

References 15 publications

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“…Their study confirmed that the sealant provided watertight closure during spinal surgeries, which was better than the standard care technologies (suture only) for dural closure in spine surgeries [10]. In another clinical study, the suitability of Duraseal for reducing scar tissue and post-operative pain after lumbar microdiscectomy was evaluated [11]. The results on 21 patients showed that Duraseal was safe and reduced post-operation pain as compared to the control group.…”

Section: Synthetic Polymer Derived Elastic Sealantsmentioning

confidence: 89%

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Elastic sealants for surgical applications

Annabi

Yue

Tamayol

et al. 2015

European Journal of Pharmaceutics and Biopharmaceutics

200

176

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Sealants have emerged as promising candidates for replacing sutures and staples to prevent air and liquid leakages during and after the surgeries. Their physical properties and adhesion strength to seal the wound area without limiting the tissue movement and function are key factors in their successful implementation in clinical practice. In this contribution, the advances in the development of elastic sealants formed from synthetic and natural materials are critically reviewed and their shortcomings are pointed out. In addition, we highlight the applications in which elasticity of the sealant is critical and outline the limitations of the currently available sealants. This review will provide insights for the development of novel bioadhesives with advanced functionality for surgical applications.

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Section: Synthetic Polymer Derived Elastic Sealantsmentioning

confidence: 89%

“…The results on 21 patients showed that Duraseal was safe and reduced post-operation pain as compared to the control group. In addition, the patients treated with the sealant had normal wound healing process with no post-operative complications [11]. …”

Section: Synthetic Polymer Derived Elastic Sealantsmentioning

confidence: 99%

Elastic sealants for surgical applications

Annabi

Yue

Tamayol

et al. 2015

European Journal of Pharmaceutics and Biopharmaceutics

200

176

View full text Add to dashboard Cite

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“…MRI provides precise visuali zation of scar tissue. In approximately 24% of patients after spinal canal surgery, the radiological eva lu ation shows a scar surrounding and infiltrating The materials used in the prevention of cicatrisation in human surgery include polytetrafluoroethylene, autogenous adipose tissue, protein polymers, hyaluronate, Adcon-L, Oxiplex/Sp, DuraGen, and DuraSeal Xact Adhesion Barrier (DSX) [10,11,12,16,18,20,21]. These products are currently available and used throughout the world.…”

Section: Discussionmentioning

confidence: 99%

Original article Nanofiber nets in prevention of cicatrisation in spinal procedures. Experimental study

Andrychowski¹,

Frontczak-Baniewicz²,

Sulejczak³

et al. 2013

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Folia Neuropathologica 2013; 51/2 147 Nanofiber nets in prevention of cicatrisation in spinal procedures. Experimental study J Ja ar ro os sł ła aw w A An nd dr ry yc ch ho ow ws sk ki i 1 1, ,2 2 , , M Ma ał łg go or rz za at ta a F Fr ro on nt tc cz za ak k--B Ba an ni ie ew wi ic cz z A b s t r a c t Excessive cicatrisation or epidural fibrosis in the operative field is an inappropriate event occasionally occurring after neurosurgical procedures (i.e., spine procedures and craniotomies). This excessive process may disturb the postoperative course and render reoperations more difficult and risky. The literature describes this phenomenon as accompanying up to 20% of neurosurgical procedures. The scar tissue that forms postoperatively adheres to the dura mater, penetrates into the spinal canal and can cause narrowing symptoms, neurological deficits and pain. The incidence and spread of this excessive scar or epidural fibrosis can be prevented through the modification of the surgical technique by incorporating endoscopic or microscopic access to minimize the operative field and the use of isolating substances (autogenous or heterogeneous) administered intraoperatively. The aim of this experimental study was to morphologically assess the cicatrisation process, adhesion and to prevent excessive scar formation with the local use of membranes manufactured by an electrospinning process (nanotechnology). We also investigated whether the biodegradable nanofibrous net triggers or modifies the immunological response or the local inflammatory process. Micro-nanofibrous membranes were produced by the electrospinning process. A biodegradable, medically certified copolymer poly(L-lactide-co-caprolactone) (PLCL) was IntroductionThe first papers on cicatrisation or the process of epidural fibrosis after neurosurgical procedures date back to the 1970s [4,26,27,43]. Developments and progress in the field of spinal surgery have caused the number of patients undergoing these procedures to multiply [4]. Long-term postoperative observations have demonstrated excessive cicatrisation within the spinal canal and its dural and neural components to be one of the factors adversely affecting the postoperative period [10,26,28,30,41,42]. We observed this improper cicatrisation involving the neural elements after the dura and arachnoid matter damage in the different neurosurgical procedures. Epidural fibrosis is considered to be one of the mechanisms that may be responsible for postoperative pain [30,41,42]. Cicatrisation is a part of the natural and normal healing process that makes any surgery possible, but excessive or inappropriate scar formation is an adverse process in the surgical context.In neurosurgery, excessive cicatrisation can lead to neurological symptoms and pain. Its prevention is based on three methods specifically designed to significantly reduce epidural fibrosis, adhesion and/or excessive cicatrisation. The first method is based on minimizing the surgical field exposure using microscopic and endoscopic approaches [16,27...

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“…Polymerization results in an exothermic reaction, the rate of which depends on the length of the cyanoacrylate monomers: the shorter the chain length, the more spontaneous the polymerization. 11 Furthermore, gelatin-formaldehyde-resorcinol (GRF) adhesives are 2-component synthetic adhesives containing a mixture of gelatin and resorcinol that is polymerized when a small amount of formaldehyde or glutaraldehyde is added. 8,9 Modern-day CA are becoming less histotoxic and more flexible.…”

mentioning

confidence: 99%