Reduction of Radiculopathy and Pain With Oxiplex/SP Gel After Laminectomy, Laminotomy, and Discectomy

Kim, Kee D.; Wang, Jeffrey C.; Robertson, Daniel P.; Brodke, Darrel S.; Olson, Erik M.; Duberg, A; BenDebba, Mohammed; Block, Kathleen M.; diZerega, Gere S.

doi:10.1097/01.brs.0000062354.26905.b8

Cited by 49 publications

(50 citation statements)

References 44 publications

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“…Six RCTs 66,73,78,84,89,106 compared surgery with intraoperative interventions and found no overall significant difference between treatment groups. Two studies 78,84 included patients with either chronic or acute sciatica and one 66 included patients who had had sciatica for longer than 3 months; the chronicity of sciatica was not reported in three studies.…”

Section: Pain Intensity At Short-term Follow-upmentioning

confidence: 99%

“…Two studies 78,84 included patients with either chronic or acute sciatica and one 66 included patients who had had sciatica for longer than 3 months; the chronicity of sciatica was not reported in three studies. 73,89,106 Three studies 73,89,106 were of moderate to good quality, with adequate randomisation in all three and allocation concealment in two. 73,89 Three studies compared disc surgery with chemonucleolysis: two were RCTs 85,88 and one was a concurrent cohort study (CCS).…”

Section: Pain Intensity At Short-term Follow-upmentioning

confidence: 99%

“…Just over half (33/62, 53%) of the disc surgery studies were RCTs, of which only two 87,99 were good quality overall (comparing disc surgery with usual care). Four RCTs 68,73,89,99 had used both adequate randomisation and allocation concealment (comparators included exercise therapy, intraoperative interventions and usual care). A further eight studies 81,[85][86][87][88]101,106,107 used adequate randomisation, but not allocation concealment (although two studies 87,106 used sealed envelopes), and one study 69 used adequate allocation concealment, but not randomisation.…”

Section: Summary Of Study Participants For Disc Surgerymentioning

confidence: 99%

See 2 more Smart Citations

The clinical effectiveness and cost-effectiveness of management strategies for sciatica: systematic review and economic model

Lewis

Williams²,

Matar³

et al. 2011

Health Technol Assess

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How to obtain copies of this and other HTA programme reports An electronic version of this title, in Adobe Acrobat format, is available for downloading free of charge for personal use from the HTA website (www.hta.ac.uk). A fully searchable DVD is also available (see below).Printed copies of HTA journal series issues cost £20 each (post and packing free in the UK) to both public and private sector purchasers from our despatch agents.Non-UK purchasers will have to pay a small fee for post and packing. For European countries the cost is £2 per issue and for the rest of the world £3 per issue. How to order:-fax (with credit card details) -post (with credit card details or cheque) -phone during office hours (credit card only).Additionally the HTA website allows you to either print out your order or download a blank order form. Contact details are as follows:Synergie UK (HTA Department) Digital House, The Loddon Centre Wade Road Basingstoke Hants RG24 8QW Email: orders@hta.ac.uk Tel: 0845 812 4000 -ask for 'HTA Payment Services' (out-of-hours answer-phone service) Fax: 0845 812 4001 -put 'HTA Order' on the fax header Payment methods Paying by chequeIf you pay by cheque, the cheque must be in pounds sterling, made payable to University of Southampton and drawn on a bank with a UK address.Paying by credit card You can order using your credit card by phone, fax or post. SubscriptionsNHS libraries can subscribe free of charge. Public libraries can subscribe at a reduced cost of £100 for each volume (normally comprising 40-50 titles). The commercial subscription rate is £400 per volume (addresses within the UK) and £600 per volume (addresses outside the UK). Please see our website for details. Subscriptions can be purchased only for the current or forthcoming volume.How do I get a copy of HTA on DVD?Please use the form on the HTA website (www.hta.ac.uk/htacd/index.shtml). HTA on DVD is currently free of charge worldwide.The website also provides information about the HTA programme and lists the membership of the various committees. HTAThe clinical effectiveness and costeffectiveness of management strategies for sciatica: systematic review and economic model NIHR Health Technology Assessment programmeThe Health Technology Assessment (HTA) programme, part of the National Institute for Health Research (NIHR), was set up in 1993. It produces high-quality research information on the effectiveness, costs and broader impact of health technologies for those who use, manage and provide care in the NHS. 'Health technologies' are broadly defined as all interventions used to promote health, prevent and treat disease, and improve rehabilitation and long-term care. The research findings from the HTA programme directly influence decision-making bodies such as the National Institute for Health and Clinical Excellence (NICE) and the National Screening Committee (NSC). HTA findings also help to improve the quality of clinical practice in the NHS indirectly in that they form a key component of the 'National Knowledge Service' . The HTA pro...

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Section: Pain Intensity At Short-term Follow-upmentioning

confidence: 99%

Section: Pain Intensity At Short-term Follow-upmentioning

confidence: 99%

Section: Summary Of Study Participants For Disc Surgerymentioning

confidence: 99%

See 1 more Smart Citation

The clinical effectiveness and cost-effectiveness of management strategies for sciatica: systematic review and economic model

Lewis

Williams²,

Matar³

et al. 2011

Health Technol Assess

View full text Add to dashboard Cite

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“…Calcium chloride inducing ionic cross-links is added to the formulation to create stronger interaction between the components. This modification prolongs the permanence of the product in the body because carboxymethil cellulose is otherwise rapidly resorbed 19,24 . Previous studies using Oxiplex have shown a significant reduction in the degree of postoperative peridural fibrosis 32 .…”

Section: Discussionmentioning

confidence: 99%

Comparison of Oxiplex and Gore-Tex effectivity in an experimental peridural fibrosis model

et al. 2009

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SummaryObjective. The authors conducted a study to compare the effectiveness of Oxiplex and Gore-tex in preventing postlaminectomy peridural fibrosis in rats. Peridural fibrosis is a common cause of pain in patients undergoing spinal surgery. To prevent scar formation numerous materials and methods have been employed such as non steroidal anti-inflammatory drugs (NSAIDs), Gelfoam, Oxiplex, Gore-tex, carboxymethil cellulose, Adcon-L, autogenous adipose grefting, mitomisin, and radiotherapy have been investigating for a long time, but only moderate success has been obtained.Methods. Laminectomies were performed at the fourth lumbar vertebra (L-4) in 30 rats. Oxiplex or Gore-Tex was applied over the dura mater with the aim to perform a blinded evaluation of their effects. In the control group, only a L-4 laminectomy was performed. Animals were sacrificed 28 days after the surgical procedure. The extent of peridural fibrosis was evaluated on spine specimens by histological analysis.Results. Both groups of animals treated with either Oxiplex or Gore-Tex showed a significant reduction in the degree of peridural fibrosis as compared to the control group. However no significant difference in the prevention of peridural fibrosis was observed between the Oxiplex and Gore-Tex groups.Conclusions. This experimental model has shown that Oxiplex and Gore-Tex are effective methods to prevent peridural fibrosis and dural adhesions at the postlaminectomy areas.KEY WORDS: Peridural fibrosis. Oxiplex. Gore-Tex. Failed back syndrome.Comparación entre la eficacia del Oxiplex y del GoreTex en un modelo experimental de fibrosis peridural ResumenObjetivo. Los autores realizaron un estudio para comparar la eficacia de Oxiplex y Gore-tex en la prevención de fibrosis peridural tras laminectomías en ratas. La fibrosis peridural es una causa común de dolor en pacientes sometidos a cirugía de la columna vertebral. Para evitar la formación de cicatriz, se han empleado numerosos materiales y métodos como los antiinflamatorios no esteroideos (AINE), Gelfoam, Oxiplex, Gore-tex, carboxymethil celulosa, Adcon-L, injertos de grasa antóloga, mitomicina o la radioterapia, pero sólo se ha obtenido resultados exitosos en pocas ocasiones.Métodos. Se realizaron laminectomías en la cuarta vértebra lumbar (L-4) en 30 ratas. Se aplicaron Oxiplex o Gore-Tex sobre la duramadre con el objetivo de realizar una evaluación ciega de sus efectos. En el grupo control, sólo se realizó la laminectomía L4. Los animales fueron sacrificados 28 días después de la intervención quirúrgica. El grado de fibrosis peridural se evaluó sobre la columna vertebral de especímenes por análisis histológico.Resultados. Ambos grupos de animales tratados con Oxiplex o Gore-Tex mostraron una reducción significativa en el grado de fibrosis peridural en comparación con el grupo control. Sin embargo, ninguna diferencia significativa en la prevención de la fibrosis peridural se observó entre los grupos de Oxiplex y Gore-Tex.Conclusiones. Este modelo experimental ha demostrado que Oxiplex y Gor...

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“…Kim òà ñï³âàâòîðè [8] àíàë³зóâàëè ðåзóëüòàòè âèêîðèñòàííя àíòèàäãåзèâíîãî ãåëю «Medisheld» чåðåз 1 òà 6 м³ñ ó хâîðèх з ãðóбèм ïàðåзîм ñòîïè ³ âèðàaeåíèм бîëüîâèм ñèíäðîмîм. Â 11 ïàö³єíò³â ï³ä чàñ зä³éñíåííя м³êðîäèñêåêòî-м³¿ ââîäèëè ãåëü, ó 7 -ãåëü íå âèêîðèñòîâóâàëè.…”

Section: кëючîâ³ ñëîâà: компресійний рубцево-спайковий епідурит резуunclassified

Neurosurgical treatment and prophylaxis of compressive cicatricial-adhesive epiduritis after lumbar microdiskectomy

Pedachenko¹,

Тарасенко²

2008

Ukr Neurosurg J

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Reduction of Radiculopathy and Pain With Oxiplex/SP Gel After Laminectomy, Laminotomy, and Discectomy

Abstract: Oxiplex/SP Gel was easy to use and safe for patients undergoing unilateral discectomy. Greater benefit in clinical outcome measures was seen in gel-treated patients, especially those with severe leg pain and weakness at baseline.

Cited by 49 publications

References 44 publications

The clinical effectiveness and cost-effectiveness of management strategies for sciatica: systematic review and economic model

The clinical effectiveness and cost-effectiveness of management strategies for sciatica: systematic review and economic model

Comparison of Oxiplex and Gore-Tex effectivity in an experimental peridural fibrosis model

Neurosurgical treatment and prophylaxis of compressive cicatricial-adhesive epiduritis after lumbar microdiskectomy

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