2012
DOI: 10.1016/j.neuint.2011.12.004
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Reduction of retrograde axonal transport associated-proteins motor proteins, dynein and dynactin in the spinal cord and cerebral cortex of hens by tri-ortho-cresyl phosphate (TOCP)

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Cited by 4 publications
(2 citation statements)
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“…TOCP is known to induce axon swelling in vivo as an early pathological event in OPIDN (Abou-Donia et al, 1988). As confirmation, we found a TOCP-induced increase in neurite diameter in pCNs with 10 M. Possible mechanisms of in vivo and in vitro axon swelling and neurite degeneration, suggested in various studies (Chang and Wu, 2006;Song et al, 2009;Song et al, 2012), include the aggregation and deprivation of neurofilaments, ␤-III-tubulin, and microtubule-associated proteins. Recently, another mechanism involved in the degeneration of cytoskeletal proteins and neurite outgrowth inhibition, namely, the self-degradation process of autophagy has been described (Chen et al, 2013).…”
Section: Discussionsupporting
confidence: 84%
“…TOCP is known to induce axon swelling in vivo as an early pathological event in OPIDN (Abou-Donia et al, 1988). As confirmation, we found a TOCP-induced increase in neurite diameter in pCNs with 10 M. Possible mechanisms of in vivo and in vitro axon swelling and neurite degeneration, suggested in various studies (Chang and Wu, 2006;Song et al, 2009;Song et al, 2012), include the aggregation and deprivation of neurofilaments, ␤-III-tubulin, and microtubule-associated proteins. Recently, another mechanism involved in the degeneration of cytoskeletal proteins and neurite outgrowth inhibition, namely, the self-degradation process of autophagy has been described (Chen et al, 2013).…”
Section: Discussionsupporting
confidence: 84%
“…Finally, decreases in retrograde axonal transport related proteins dynein and dynactin have been observed in the spinal cord and cerebral cortex of hens after exposure to acutely toxic doses of TOCP (Song et al, 2012).…”
Section: Mechanisms Of the Long Term Neuropsychiatric Effects Of Acutmentioning
confidence: 99%