This article focuses on new virtual advances to solve technical problems usually encountered by paleontologists when using X-ray computed tomography (XCT), such as (i) the limited scanning envelope (i.e., field of view of CT systems/machines) to acquire data on large structures; (ii) the use in the same study of biological objects acquired with different types of computed tomography systems (medical and laboratory XCTs and laboratory high-resolution XµCT) and therefore different resolutions; and (iii) matrix removal within the fossil (e.g., cranial cavities, intratrabecular cavities, among other cavities). All these problems are very common in paleontology, and therefore, solving them is important to save effort and the time invested in data processing. In this article, we propose various solutions to tackle these issues, based on new technical advances focused on improving and processing the images obtained from XCT. Other aspects include image filtering and histogram calibration to remove background noise and artifacts. Such artifacts can result from dense mineral inclusion occurring during the fossilization process or derived from anthropogenic restoration of the sample. Accordingly, here, we provide a protocol to acquire data on samples with size that exceed the scanning envelope of the X-ray tomography machine, joining the parts with enough accuracy, and we propose the use of the interpolation "bicubic" method. Moreover, using this method, it is possible to use medical/laboratory XCT data together with XµCT data and therefore opening new ways to manipulate the acquired data within the image stack. Another advantage is the use of plugins for quantitative analysis, which require data with isometric voxels, such as the plugin BoneJ of the software ImageJ. We also deal with the problem of removing the exogenous material that usually fills the internal cavities of fossils by means of using filters based on edge detection by gradient. Applying this method, it is possible to segment the non-bony matrix parts more quickly and efficiently. All of this is exemplified using five fossil skulls belonging to the cave bear group (Ursus spelaeus sensu lato), an iconic fossil species from the Pleistocene of Eurasia.