Reduction of submicron particle agglomeration via melt foaming in solid crystalline suspension

Igreja, Philip da; Klump, D; Bartsch, Jens; Thommes, Markus

doi:10.1080/01932691.2022.2146707

Cited by 2 publications

(1 citation statement)

References 33 publications

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“…Next to binary solid crystalline suspensions, the influence of the addition of sodium dodecyl sulfate on particle agglomeration and drug dissolution was investigated. Foaming occurred during the milling process, which prevented particle agglomeration as drug particles were assumed to assemble at the interface of the gas bubbles and the xylitol [ 36 ].…”

Section: Introductionmentioning

confidence: 99%

Insights into the Mechanism of Enhanced Dissolution in Solid Crystalline Formulations

Justen,

Schaldach,

Thommes

2024

Pharmaceutics

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Solid dispersions are a promising approach to enhance the dissolution of poorly water-soluble drugs. Solid crystalline formulations show a fast drug dissolution and a high thermodynamic stability. To understand the mechanisms leading to the faster dissolution of solid crystalline formulations, physical mixtures of the poorly soluble drugs celecoxib, naproxen and phenytoin were investigated in the flow through cell (apparatus 4). The effect of drug load, hydrodynamics in the flow through cell and particle size reduction in co-milled physical mixtures were studied. A carrier- and drug-enabled dissolution could be distinguished. Below a certain drug load, the limit of drug load, carrier-enabled dissolution occurred, and above this value, the drug defined the dissolution rate. For a carrier-enabled behavior, the dissolution kinetics can be divided into a first fast phase, a second slow phase and a transition phase in between. This study contributes to the understanding of the dissolution mechanism in solid crystalline formulations and is thereby valuable for the process and formulation development.

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Section: Introductionmentioning

confidence: 99%