Reduction of Visceral Fat Correlates with the Decrease in the Number of Obesity-Related Cardiovascular Risk Factors in Japanese with Abdominal Obesity (VACATION-J Study)

Hiuge-Shimizu, Aki; Kishida, Ken; Funahashi, Tohru; Ishizaka, Yuko; Oka, Rie; Okada, Minoru; Suzuki, Shizu; Takaya, Norihide; Nakagawa, Tohru; Fukui, Toshiki; Fukuda, Hiroshi; Watanabe, Nobuhisa; Yoshizumi, Tohru; Ohira, Tetsuya; Nakamura, Tadashi; Matsuzawa, Yūji; Yamakado, Minoru; Shimomura, Iichiro

doi:10.5551/jat.12963

Cited by 45 publications

(30 citation statements)

References 44 publications

(51 reference statements)

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“…The observed association between visceral obesity and preoperative metabolic comorbidities is consistent with previous studies that have linked cardiovascular risk factors to increased visceral fat 19 . Hiuge-Shimizu et al have reported that VFA and SFA were associated with obesity-related diabetes and hypertension whereas BMI was not 18, 19 .…”

Section: Discussionsupporting

confidence: 91%

“…Recent studies have utilized quantitative computed tomography (CT) to determine visceral obesity by measuring visceral fat area (VFA) 17 or visceral fat/subcutaneous fat area (V/S ratio) 18 and significant associations have been reported. A VFA of >100 cm 2 or V/S > 0.4 is associated with the metabolic syndrome 19 and poor surgical outcomes 6, 17 . Moreover, diagnostic CT adiposity measurements before colon cancer surgery, have yielded a significant association with short term complications such as wound complication, venous thrombosis and incisional hernia, compared to BMI 20, 21 .…”

Section: Introductionmentioning

confidence: 99%

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Quantitative Assessment of Visceral Obesity and Postoperative Colon Cancer Outcomes

Ozoya

Siegel

Srikumar

et al. 2017

Journal of Gastrointestinal Surgery

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Background Quantitative computed tomography (CT) assessment of visceral adiposity may be superior to body mass index (BMI) as a predictor of surgical morbidity. We sought to examine the association of CT measures of obesity and BMI with short-term post-operative outcomes in colon cancer patients. Methods In this retrospective study, 110 patients treated with colectomy for Stage I–III colon cancer were classified as obese or non-obese by pre-operative CT-based measures of adiposity or BMI. [Obese: BMI≥30kg/m2, visceral fat area (VFA) to subcutaneous fat area ratio (V/S) ≥0.4 and VFA>100cm2)]. Post-operative morbidity and mortality rates were compared. Results Obese patients, by V/S and VFA but not BMI, were more likely to be male and have pre-existing hypertension and diabetes. The overall complication rate was 25.5% and there were no mortalities. Obese patients by VFA (with a trend for VS but not BMI) were more likely to develop postoperative complications as compared to patients classified as non-obese; VFA (30.5% vs.10.7%, p= 0.03), VS (29.2% vs. 9.5%, p=0.05) and BMI (32.4% vs. 21.9%, p=0.23). Conclusions Elevated visceral obesity quantified by CT is associated with the presence of key metabolic comorbidities and increased post-operative morbidity and may be superior to BMI for risk stratification.

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Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Quantitative Assessment of Visceral Obesity and Postoperative Colon Cancer Outcomes

Ozoya

Siegel

Srikumar

et al. 2017

Journal of Gastrointestinal Surgery

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“…Even in mildly obese individuals, visceral adiposity is related to a cluster of risk factors and coronary artery disease (CAD) 6,7 . This pathogenetic condition, in which visceral fat accumulation locates upstream of various disorders related to CVD is conceptualized as visceral fat syndrome.…”

Section: Visceral Fat Syndromementioning

confidence: 99%

Adiponectin and the cardiometabolic syndrome: An epidemiological perspective

Funahashi

Matsuzawa

2014

Best Practice & Research Clinical Endocrinology & Metab

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“…These cytokine changes induce insulin resistance and play a major role in the pathogenesis of endothelial dysfunction and the subsequent atherosclerosis. The rate of visceral fat accumulation is also different according to the gender and ethnic background, being more prominent in white men, African American women, and Asian Indian and Japanese men and women (Hiuge-Shimizu et al 2012). Such differences may explain the variation in the cardiometabolic risk between different populations.…”

Section: Introductionmentioning

confidence: 98%

Obesity-related hypertension: possible pathophysiological mechanisms

Vaněčková¹,

Maletı́nská²,

Behuliak³

et al. 2014

Journal of Endocrinology

130

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Hypertension is one of the major risk factors of cardiovascular diseases, but despite a century of clinical and basic research, the discrete etiology of this disease is still not fully understood. The same is true for obesity, which is recognized as a major global epidemic health problem nowadays. Obesity is associated with an increasing prevalence of the metabolic syndrome, a cluster of risk factors including hypertension, abdominal obesity, dyslipidemia, and hyperglycemia. Epidemiological studies have shown that excess weight gain predicts future development of hypertension, and the relationship between BMI and blood pressure (BP) appears to be almost linear in different populations. There is no doubt that obesity-related hypertension is a multifactorial and polygenic trait, and multiple potential pathogenetic mechanisms probably contribute to the development of higher BP in obese humans. These include hyperinsulinemia, activation of the renin-angiotensin-aldosterone system, sympathetic nervous system stimulation, abnormal levels of certain adipokines such as leptin, or cytokines acting at the vascular endothelial level. Moreover, some genetic and epigenetic mechanisms are also in play. Although the full manifestation of both hypertension and obesity occurs predominantly in adulthood, their roots can be traced back to early ontogeny. The detailed knowledge of alterations occurring in the organism of experimental animals during particular critical periods (developmental windows) could help to solve this phenomenon in humans and might facilitate the age-specific prevention of human obesity-related hypertension. In addition, better understanding of particular pathophysiological mechanisms might be useful in so-called personalized medicine. Key Words" obesity " hypertension " sympathetic nervous system " renin-angiotensin system " critical developmental periods " epigenetics " rat

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Reduction of Visceral Fat Correlates with the Decrease in the Number of Obesity-Related Cardiovascular Risk Factors in Japanese with Abdominal Obesity (VACATION-J Study)

Cited by 45 publications

References 44 publications

Quantitative Assessment of Visceral Obesity and Postoperative Colon Cancer Outcomes

Quantitative Assessment of Visceral Obesity and Postoperative Colon Cancer Outcomes

Adiponectin and the cardiometabolic syndrome: An epidemiological perspective

Obesity-related hypertension: possible pathophysiological mechanisms

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