2001
DOI: 10.1016/s0895-7061(01)02159-8
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Reduction of white coat effect by cilnidipine in essential hypertension

Abstract: Stress elevates blood pressure (BP) by increased sympathetic nerve activity. Cilnidipine, a novel dihydropyridine calcium antagonist that has inhibitory actions on N-type as well as L-type voltage-dependent calcium channels, has been reported to attenuate the cold stress-induced increase in plasma norepinephrine and BP in rats. Because white coat effect is associated with an enhanced pressor response to mental stress, we postulated that cilnidipine would attenuate white coat effect in patients with essential h… Show more

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Cited by 29 publications
(16 citation statements)
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“…20,21 There was a significant negative correlation between the degree of SBP change and that of PR change after Cilnidipine treatment. This finding is an agreement with several previous studies 22,23 in which Cilnidipine suppressed sympathetic nervous activity, especially under a stress-induced hyperactive condition.…”
Section: Discussionsupporting
confidence: 94%
“…20,21 There was a significant negative correlation between the degree of SBP change and that of PR change after Cilnidipine treatment. This finding is an agreement with several previous studies 22,23 in which Cilnidipine suppressed sympathetic nervous activity, especially under a stress-induced hyperactive condition.…”
Section: Discussionsupporting
confidence: 94%
“…This finding is in agreement with several previous studies (22)(23)(24)(25) in which cilnidipine suppressed sympathetic nervous activity, especially under a stress-induced hyperactive condition.…”
Section: Discussionsupporting
confidence: 94%
“…20,21 There was a significant negative correlation between the degree of SBP change and that of PR change after Cilnidipine treatment. This finding is an agreement with several previous studies 22,23 in which Cilnidipine suppressed sympathetic nervous activity, especially under a stress-induced hyperactive condition. Blood pressure control is important in suppressing the onset of renal dysfunction.…”
supporting
confidence: 94%