Reduction of ZFX levels decreases histone H4 acetylation and increases Pol2 pausing at target promoters
Emily Hsu,
Katherine Hutchison,
Yao Liu
et al.
Abstract:The ZFX transcriptional activator binds to CpG island promoters, with a major peak at ∼200–250 bp downstream from transcription start sites. Because ZFX binds within the transcribed region, we investigated whether it regulates transcriptional elongation. We used GRO-seq to show that loss or reduction of ZFX increased Pol2 pausing at ZFX-regulated promoters. To further investigate the mechanisms by which ZFX regulates transcription, we determined regions of the protein needed for transactivation and for recruit… Show more
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