Reduction-sensitive polymeric carrier for the targeted delivery of a quinazoline derivative for enhanced generation of reactive oxygen species against cancer

Abstract

A reduction-sensitive polymeric carrier was synthesized for the targeted delivery of a quinazoline derivative to deplete intracellular glutathione and promote the reactive oxygen species level against cancer.

Inhibition of thioredoxin reductase and upregulation of apoptosis genes for effective anti-tumor sono-chemotherapy using a meso-organosilica nanomedicine

“…With the development of nanomedicines, various nanomaterials such as liposomes, mesoporous silica and polymers have been used as drug carriers to improve the bioavailability and the efficacy of drugs by regulating drug release rate and enhancing drug solubility, stability, and tissue permeability. 28,29 Mesoporous organosilica spheres (MOS) may be an ideal platform for drug delivery and release because of their controllable pore structure, abundant functional groups, large specific surface area and pore volume, biodegradability along with excellent biocompatibility. 30 In addition, the hydrophobic organic pores of MOS enable them to function as cavitation nuclei, thereby enhancing the sono-cavitation effect and enhancing the antitumor sonodynamic therapy (SDT).…”