Reductions in aggression and dominance status in guinea pigs following bilateral lesions in the basolateral amygdala or lateral septum

Levinson, Daniel M.; Reeves, Dennis; Buchanan, Douglas R.

doi:10.1016/0031-9384(80)90318-2

Cited by 16 publications

(6 citation statements)

References 33 publications

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“…In a similar way to parental behavior, aggression is another innate behavior which has been shown to be largely controlled via neural groups present in the hypothalamus [219][220][221][222][223][224][225][226][227][228][229][230][231] , while extrahypothalamic neurons have been shown to control the valence of aggression [232][233][234][235][236][237][238][239][240][241][242][243][244][245][246][247][248] .…”

Section: Neural Substrates Of Aggressionmentioning

confidence: 99%

A neural network for intermale aggression to establish social hierarchy

et al. 2018

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Intermale aggression is used to establish social rank. Several neuronal populations have been implicated in aggression, but the circuit mechanisms that shape this innate behavior and coordinate its different components (including attack execution and reward) remain elusive. We show that dopamine transporter-expressing neurons in the hypothalamic ventral premammillary nucleus (PMv neurons) organize goal-oriented aggression in male mice. Activation of PMv neurons triggers attack behavior; silencing these neurons interrupts attacks. Regenerative PMv membrane conductances interacting with recurrent and reciprocal excitation explain how a brief trigger can elicit a long-lasting response (hysteresis). PMv projections to the ventrolateral part of the ventromedial hypothalamic and the supramammillary nuclei control attack execution and aggression reward, respectively. Brief manipulation of PMv activity switched the dominance relationship between males, an effect persisting for weeks. These results identify a network structure anchored in PMv neurons that organizes aggressive behavior and, as a consequence, determines intermale hierarchy.

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Section: Neural Substrates Of Aggressionmentioning

confidence: 99%

A neural network for intermale aggression to establish social hierarchy

et al. 2018

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“…The amygdala is well known to mediate social behaviors (73, 74). For example, lesions of BLA result in decreased aggression-like behavior and increased social interactions (75, 76), and changes in transcriptional regulation in BLA are observed after social interactions (74). Decreased dendritic spine density in Kmt2a- HET and Kdm5c -KO mice inversely correlates with increased social dominance and aggression (Figures 4 and 6), suggesting that decreased spine density does not represent a loss-of-function in the amygdala, and rather, may reflect a loss of inhibitory control over the amygdala.…”

Section: Discussionmentioning

confidence: 99%

Mutually suppressive roles of KMT2A and KDM5C in behaviour, neuronal structure, and histone H3K4 methylation

Vallianatos

Raines

Porter

et al. 2019

Preprint

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Histone H3 lysine 4 methylation (H3K4me) is extensively regulated by numerous writer and eraser enzymes in mammals. Nine H3K4me enzymes are associated with neurodevelopmental disorders to date, indicating their important roles in the brain. However, interplay among H3K4me enzymes during brain development remains largely unknown. Here, we show functional interactions of a writer-eraser duo, KMT2A and KDM5C, which are responsible for Wiedemann-Steiner Syndrome (WDSTS), and mental retardation X-linked syndromic Claes-Jensen type (MRXSCJ), respectively. Despite opposite enzymatic activities, the two mouse models deficient for either Kmt2a or Kdm5c shared reduced dendritic spines and increased aggression. Double mutation of Kmt2a and Kdm5c clearly reversed dendritic morphology, key behavioral traits including aggression, and partially corrected altered transcriptomes and H3K4me landscapes. Thus, our study uncovers common yet mutually suppressive aspects of the WDSTS and MRXSCJ models and provides a proof of principle for balancing a single writer-eraser pair to ameliorate their associated disorders.

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“…The preoptic area is one of the most conserved regions of the SDMN that is also involved in male sex behavior. In turn, basolateral areas of the amygdala have long been implicated in male mammalian aggression and recent evidence for the involvement of the hippocampus suggest regulatory effects from AV signaling 79,80 . For submissive behavior in losers, females maintained use of the fish homolog to the medial extended amygdala (i.e., the supracommisural nucleus), but males shifted to activation in the lateral septum.…”

Section: Social Dominance: Winner‐loser Dynamics and Assessment Mecha...mentioning

confidence: 99%

Social zebrafish:Danio rerioas an emerging model in social neuroendocrinology

Kareklas

Teles

Nunes

et al. 2023

J Neuroendocrinology

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The fitness benefits of social life depend on the ability of animals to affiliate with others and form groups, on dominance hierarchies within groups that determine resource distribution, and on cognitive capacities for recognition, learning and information transfer. The evolution of these phenotypes is coupled with that of neuroendocrine mechanisms, but the causal link between the two remains underexplored. Growing evidence from our research group and others demonstrates that the tools available in zebrafish, Danio rerio, can markedly facilitate progress in this field. Here, we review this evidence and provide a synthesis of the state‐of‐the‐art in this model system. We discuss the involvement of generalized motivation and cognitive components, neuroplasticity and functional connectivity across social decision‐making brain areas, and how these are modulated chiefly by the oxytocin‐vasopressin neuroendocrine system, but also by reward‐pathway monoamine signaling and the effects of sex‐hormones and stress physiology.

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Reductions in aggression and dominance status in guinea pigs following bilateral lesions in the basolateral amygdala or lateral septum

Cited by 16 publications

References 33 publications

A neural network for intermale aggression to establish social hierarchy

A neural network for intermale aggression to establish social hierarchy

Mutually suppressive roles of KMT2A and KDM5C in behaviour, neuronal structure, and histone H3K4 methylation

Social zebrafish:Danio rerioas an emerging model in social neuroendocrinology

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