Reductive Amination of Triacetoneamine with n-Butylamine Over Cu–Cr–La/γ-Al2O3

Abstract

A series of Cu-based catalysts were prepared and examined for the reductive amination of triacetoneamine with n-butylamine, thereinto, Cu-Cr-La/c-Al 2 O 3 showed excellent results. The catalysts were studied by XRD, XPS, H 2 -TPR and NH 3 -TPD. It was found that doped Cr remarkably enhanced the activity of Cu/c-Al 2 O 3 due to better dispersion of Cu 0 , which is believed to be the active site for the reductive amination. Additionally, it was obvious that introduction of La to Cu-Cr/c-Al 2 O 3 led to a higher selectivity and longer lifetime. The reaction parameters were optimized and N-butyl-2,2,6,6-tetramethyl-4-piperidinamine was obtained in a yield of 94%.

An Efficient Method for the Production of Cyclohexylamine from Cyclohexanone and Ammonia over Cu-Cr-La/γ-Al2O3

“…It was found that Cu-Cr-La/γ-Al 2 O 3 displayed the best catalytic performance, which was accordance with the results Sun et al reported 20 (Sun et al, 2011), so this catalyst was used for the following research.…”

A novel co-production process for piperazine and its N-monoalkyl derivatives

“…Catalyst selection Although our previous work had shown Cu-Cr-La/c-Al 2 O 3 to be an effective catalyst for reductive amination of alcohols, aldehydes, and ketones [20][21][22], the catalyst had to be optimized for this reaction system. This was achieved by varying the amount of La in the catalyst; the results are listed in Table 1.…”

“…The peak at 932.59 eV can be assigned to the binding energy of the Cu 0 species at the Cu2p3/2 level. Therefore, it is likely that the co-production process proceeds smoothly because the copper is sufficiently active for reductive amination of alcohols [20][21][22].…”

“…Preparation, activity evaluation, and characterization of the catalyst Preparation and evaluation of the activity of Cu-Cr-La/c-Al 2 O 3 were performed in accordance with our previous work [21].…”

“…tubular fixed-bed reactor in the presence of hydrogen. Cu-Cr-La/c-Al 2 O 3 (40 mL) was loaded into the reactor and reduced in a stream of hydrogen as described elsewhere [21]. As an example, co-production of piperazine and N-monoisopropylpiperazine is described here and is presented schematically in Scheme 1.…”