Reductive Coupling of Geminal Dichlorides by Iron(II) Oxalate Dihydrate

Synthesis and Anti-inflammatory Study of Novel N-substituted Hydroacridine- 1,8-diones and Bis-hexahydroacridine-1,8-dione Derivatives

“…The molecular structure of the products 3a-f was elucidated from their IR, 1 H-NMR and 13 C-NMR spectra. The IR spectrum of these products in KBr showed broad bands at 3397-3421Cm -1 assigned for both of phenolic and alcoholic OH groups, and strong bands ranged from 1630-1648Cm -1 related to carbonyl groups.…”

“…IR (cm -1 ) spectra were recorded (KBr disc) on a Shimadzu DR-8001 spectrophotometer. 1 H-NMR and 13 C-NMR (DMSO-d 6 or CDCl 3 ) spectra were recorded at 400 MHz on a Varian Mercury-300 BB at Sohag University, the chemical shift is expressed in δ value (ppm) using TMS as an internal reference Evaluation of Anti-…”

“…Although many researchers have devoted their studies on synthesis of acridine compounds and their pharmaceutical applications as anti-tumor [6][7][8][9], anti-bacterial [10], anti-malarial [11] and anti-inflammatory agents [12]. Acridinediones, in particular, have been identified as anti-malarial and anti-tumor agents [13][14][15]. Hexahydroacridine-1,8-dione derivatives are also reported to possess important properties such as high fluorescence efficiency [16].…”

9-(1,3-Benzodioxol-5-yl)-10-(4-chlorophenyl)-3,3,6,6-tetramethyl-3,4,6,7-tetrahydroacridine-1,8(2H,5H,9H,10H)-dione

“…For related literature, see: Wysocka-Skrzela & Ledochowski (1976); Reil et al (1994); Mandi et al (1994); Thull & Testa (1994); Khurana et al (1990); Popielarz et al (1997); Srividya et al (1996); Tu et al (2004Tu et al ( , 2006. For general background, see: Cremer & Pople (1975).…”

“…Many of the natural and synthetic compounds containing the acridine skeleton display interesting biological and physical activities, such as antimalaria (Wysocka-Skrzela & Ledochowski, 1976;Reil et al, 1994;Mandi et al, 1994;Thull & Testa, 1994) and antitumor agents (Khurana et al, 1990), and multi-hydroacridineone derivatives have been reported to have high fluorescence efficiency and can be used as fluorescent molecular probes for monitoring of polymerization process (Popielarz et al, 1997). They are also increasingly receiving attention, due to their likeness in properties with those of 1,4-dihydropyridines, which have similarities in structure to the biologically important compounds such as NADH and NADPH (Srividya et al, 1996).…”