Reengineering Bone-Implant Interfaces for Improved Mechanotransduction and Clinical Outcomes

3D printed submicron patterns orchestrate the response of macrophages

“…48 Unraveling the role of ECM topographies in the polarization of macrophages has motivated researchers to use patterning techniques for the development of ECM-mimicking implant surfaces. The surface topography of implants influences the adhesive interactions, 51 cell morphology 52,53 and gene expression [54][55][56] of the cells that come into contact with them. The type and dimensions of surface features play a crucial role in modulating the response of both immune (e.g., monocytes and macrophages) 57 and bone (e.g., osteoblasts and osteoclasts) cells 58 existing in the tissue microenvironment.…”

Quercetin alleviates nanoparticle-induced osteolysis via deactivating pyroptosis

“…People who were suffering from aseptic loosening or total joint replacement were found to have a common characteristic: low osteogenic potential. 42 Based on previous reports, inflammatory cytokines, such as IL-1β, can impair osteoblast differentiation. 43 Our work not only confirmed this result, but also found that Que reversed the negative effect of IL-1β on the differentiation of osteoblast.…”

Mechanical stimulation devices for mechanobiology studies: a market, literature, and patents review

“…In this sense, the environment plays an important role in many cellular processes, such as cellular adhesion, migration, proliferation, differentiation, and apoptosis [15]. Given the importance of mechanical interactions in cellular behaviour, mechanobiology has emerged as a novel interdisciplinary field combining biology, mechanics, and engineering, which aims to understand how cells sense and behave in response to mechanical stimuli [7,11,16,17]. Over the past few decades, researchers have developed systems to control the cellular microenvironment and, while some focus on improving cell culture conditions, others aim to study the effects of a particular mechanical stimulus on cells by using unique cells or biomaterial-based constructs.…”