Reevaluating Anticoagulation in Antiphospholipid Syndrome: The Role of Apixaban in the Current Treatment Paradigm

Galli, Mattia; Sciarretta, Sebastiano; Frati, Giacomo; Biondi-Zoccai, Giuseppe

doi:10.1097/fjc.0000000000001585

Journal of Cardiovascular Pharmacology

2024

DOI: 10.1097/fjc.0000000000001585

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Reevaluating Anticoagulation in Antiphospholipid Syndrome: The Role of Apixaban in the Current Treatment Paradigm

Mattia Galli,

Sebastiano Sciarretta,

Giacomo Frati

et al.

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Cited by 1 publication

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Antiphospholipid Syndrome: Insights into Molecular Mechanisms and Clinical Manifestations

Celia,

Galli,

Mancuso

et al. 2024

JCM

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Antiphospholipid syndrome (APS) is a complex systemic autoimmune disorder characterized by a hypercoagulable state, leading to severe vascular thrombosis and obstetric complications. The 2023 ACR/EULAR guidelines have revolutionized the classification and understanding of APS, introducing broader diagnostic criteria that encompass previously overlooked cardiac, renal, and hematologic manifestations. Despite these advancements, diagnosing APS remains particularly challenging in seronegative patients, where traditional tests fail, yet clinical symptoms persist. Emerging non-criteria antiphospholipid antibodies offer promising new diagnostic and management avenues for these patients. Managing APS involves a strategic balance of cardiovascular risk mitigation and long-term anticoagulation therapy, though the use of direct oral anticoagulants remains contentious due to varying efficacy and safety profiles. This article delves into the intricate pathogenesis of APS, explores the latest classification criteria, and evaluates cutting-edge diagnostic tools and therapeutic strategies.

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Antiphospholipid Syndrome: Insights into Molecular Mechanisms and Clinical Manifestations

Celia,

Galli,

Mancuso

et al. 2024

JCM

View full text Add to dashboard Cite

show abstract

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Reevaluating Anticoagulation in Antiphospholipid Syndrome: The Role of Apixaban in the Current Treatment Paradigm

Cited by 1 publication

References 14 publications

Antiphospholipid Syndrome: Insights into Molecular Mechanisms and Clinical Manifestations

Antiphospholipid Syndrome: Insights into Molecular Mechanisms and Clinical Manifestations

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