In the 1970s and 1980s, regional analysis was an influential part of archaeological research, providing a discrete set of geographical tools inspired by a processual epistemological and interpretive perspective. With the advent of new technologies, new methods, and new paradigms, archaeological research on regional space has undergone significant changes. This article reviews the state of regional archaeology, beginning with a consideration of its history and a discussion of the fundamental issues facing regional investigations before focusing on developments over the last several years. On one hand, the diversification of archaeological theory has created new paradigms for thinking about human relationships with one another and with the physical environment across regional space; in this regard, historical ecology, landscape archaeology, and evolutionary theory have been particularly influential in recent years. This has led to a corresponding diversification of the traditional methods of regional analysis. Most notably, the advent of powerful digital technologies has introduced new tools, especially those from the geographic information sciences, that build on the quantitative methods of past approaches. The investigation of regional data is no longer based on a discrete toolkit of simple mathematical and graphical procedures for representing spatial relationships. Instead, regional archaeology has matured into a diversity of multiscalar spatial and geostatistical techniques that inform many areas of archaeological inquiry.