2021
DOI: 10.1111/ped.14596
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Reevaluation of concurrent acetylcholinesterase and hematoxylin and eosin staining for Hirschsprung’s disease

Abstract: Background Acetylcholinesterase (AChE) histochemistry has been widely performed for the histopathological diagnosis of Hirschsprung’s disease (HD). However, we occasionally come across diagnostic difficulties. We conducted concurrent AChE histochemistry and hematoxylin and eosin (HE) staining to validate the ancillary value of this technique. Methods Of 177 patients diagnosed using AChE histochemistry from January 2014 to December 2016, 90 patients underwent formalin‐fixed paraffin‐embedded HE staining. The hi… Show more

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Cited by 5 publications
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“…However, idiopathic megacolon does not have a significantly narrowed intestinal segment, and the expanded intestinal segment is the diseased one. The intestinal segment is characterized by a decrease in the number and degeneration of myenteric ganglia in the intestinal wall, normal acetylcholinesterase activity, thin smooth muscle layer of the intestinal wall, and weak bowel movements (19,20). In the physical examination, the main difference lies in the disappearance of anorectal suppression reflex in adult congenital megacolon.…”
Section: Discussionmentioning
confidence: 99%
“…However, idiopathic megacolon does not have a significantly narrowed intestinal segment, and the expanded intestinal segment is the diseased one. The intestinal segment is characterized by a decrease in the number and degeneration of myenteric ganglia in the intestinal wall, normal acetylcholinesterase activity, thin smooth muscle layer of the intestinal wall, and weak bowel movements (19,20). In the physical examination, the main difference lies in the disappearance of anorectal suppression reflex in adult congenital megacolon.…”
Section: Discussionmentioning
confidence: 99%