2004
DOI: 10.1002/cncr.20426
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Reevaluation of prognostic factors for survival after liver resection in patients with hepatocellular carcinoma in a Japanese nationwide survey

Abstract: BACKGROUND Advances in the diagnosis and surgical treatment of hepatocellular carcinoma (HCC) have improved the prognosis for patients with HCC who undergo liver resection. The objective of this study was to evaluate prognostic predictors for patients with HCC who underwent liver resection in a Japanese nationwide data base. METHODS In this study, the authors analyzed 12,118 patients with HCC in a Japanese nationwide data base who underwent liver resection between 1990 and 1999 and compared them with a previou… Show more

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Cited by 421 publications
(343 citation statements)
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“…Five-year survival rates are > 50% after the resection of solitary tumors, whereas rates of 20%-30% have been reported for 3 or more nodules [28][29][30] . With respect to tumor size, 5-year survival rates for patients with HCCs < 2 cm, 2-5 cm, and > 5 cm are 66%, 52%, and 37%, respectively [28][29][30] . However, in selected cases with proper hepatic function, large single HCCs can be surgically removed with favorable long-term survival outcomes [29] .…”
Section: Hepatic Resectionmentioning
confidence: 95%
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“…Five-year survival rates are > 50% after the resection of solitary tumors, whereas rates of 20%-30% have been reported for 3 or more nodules [28][29][30] . With respect to tumor size, 5-year survival rates for patients with HCCs < 2 cm, 2-5 cm, and > 5 cm are 66%, 52%, and 37%, respectively [28][29][30] . However, in selected cases with proper hepatic function, large single HCCs can be surgically removed with favorable long-term survival outcomes [29] .…”
Section: Hepatic Resectionmentioning
confidence: 95%
“…Although the BCLC algorithm mandates Child-Pugh A liver function without portal hypertension for hepatic resection, selective resection has been attempted in HCC patients exhibiting upper Child-Pugh B liver function or mild portal hypertension in Asian countries, with reference to the ICG15 value [6,26] . Prognosis after hepatic resection is determined by number and size of tumor, vascular invasion, and level of alpha-fetoprotein [28][29][30] . Five-year survival rates are > 50% after the resection of solitary tumors, whereas rates of 20%-30% have been reported for 3 or more nodules [28][29][30] .…”
Section: Hepatic Resectionmentioning
confidence: 99%
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“…Numerous publications have cited a strong correlation between recurrent disease and high AFP levels, and some have suggested an AFP level > 400 ng/mL as a cutoff. [47][48][49][50][51][52][53] There is still no agreement about or strong evidence for using a specific AFP level as a cutoff in clinical practice.…”
Section: What Are the Best Hcc Staging Systems For Making Decisions Amentioning
confidence: 99%
“…7 Lee el al. 8 reported a 3-year survival of 82.5% for tumors 2 cm and 67.7% for tumors between 2 and 3 cm.…”
mentioning
confidence: 99%