Reevaluation of the Role of Duration of Morning Stiffness in the Assessment of Rheumatoid Arthritis Activity

Khan, Nasim A.; Yazıcı, Yusuf; Calvo‐Alén, Jaime; Dadonienė, Jolanta; Gossec, Laure; Hansen, Troels Mørk; Huisman, Margriet A.; Kallikorm, Riina; Müller, Raili; Liveborn, Margareth; Oding, Rolf; Лучихина, Е. Л.; Naranjo, Antonio; Rexhepi, Sylejman; Taylor, Peter; Tlustochowich, Witold; Tsirogianni, Afrodite; Sokka, Tuulikki

doi:10.3899/jrheum.081175

Cited by 60 publications

(62 citation statements)

References 28 publications

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“…Many persons with RA consider morning stiffness to be problematic and the level of morning stiffness is correlated with pain and physical capacity (Khan et al 2009). Morning stiffness in itself can be problematic for intimate relationships if a person prefers to engage in sexual activities in the morning when fatigue can be less troublesome.…”

Section: How Does Ra Affect Sexual Health and Intimate Relationships?mentioning

confidence: 99%

Sexual Health and Intimate Relationships in Rheumatoid Arthritis

Josefsson¹,

Öberg²

2012

Rheumatoid Arthritis - Etiology, Consequences and Co-Morbidities

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Section: How Does Ra Affect Sexual Health and Intimate Relationships?mentioning

confidence: 99%

Sexual Health and Intimate Relationships in Rheumatoid Arthritis

Josefsson¹,

Öberg²

2012

Rheumatoid Arthritis - Etiology, Consequences and Co-Morbidities

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“…QUEST-RA provides data on current clinical status, disease activity, and patient reported health in many countries (59,(92)(93)(94)(95)(98)(99)(100) and serves as an example of the value of data collection in individual clinics. Some observations from QUEST-RA will be reviewed here.…”

Section: Quantitative Measuring Beyond Disease Activitymentioning

confidence: 99%

“…The SPERA format was used to document that patients with RA in 2000 had considerably better status than all patients seen in 1985 in the same clinical setting (41). SPERA has been used to collect comprehensive baseline clinical data in more than 8,000 patients in 32 countries for the QUEST-RA program (59,(92)(93)(94)(95).…”

Section: Quantitative Measuring Beyond Disease Activitymentioning

confidence: 99%

Assessment of Rheumatoid Arthritis in Clinical Care

Sokka

2010

Turk J Rheumatol

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Abst ractQuantitative clinical monitoring of patients with musculoskeletal conditions should be included in the infrastructure of every clinical practice. Quantitative monitoring improves the physician's capacity to assess and document a patient's clinical status and changes over time, which leads to greater accuracy in the underlying rationale for clinical decisions. Furthermore, routine data collection in consecutive patients facilitates analyses of groups of patients over long periods in usual care, beyond information that can be obtained from randomized clinical trials. (

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“…In particular, patients with RA experience joint pain, morning stiffness, and functional disability in the early morning hours [11]. Approximately 50% of patients experience IMF for at least 1 h/day [2,3]. This circadian pattern correlates with an early morning rise in circulating levels of pro-inflammatory cytokines, such as interleukin (IL)-6, and in the decreased secretion of cortisol, suggesting that clinical symptoms may be related to hormonal and immune circadian variations [12,13].…”

Section: Introductionmentioning

confidence: 99%

“…Impaired morning function (IMF) due to joint pain and stiffness is a commonly reported feature of rheumatoid arthritis (RA) [1][2][3]. Up to 69% of patients in the large QUEST-RA database of more than 5,000 patients experienced IMF [4].…”

Section: Introductionmentioning

confidence: 99%

Dissonance between physicians’ and patients’ perspectives on managing impaired morning function in Asian patients with rheumatoid arthritis

Mok

Cha

Perez

et al. 2017

Hong Kong Bulletin on Rheumatic Diseases

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Objectives To estimate the prevalence of impaired morning function (IMF) in rheumatoid arthritis (RA), and to understand physicians’ and patients’ perceptions on the impact of IMF and treatment in selected Asian countries. Methods A survey on the impact of IMF was conducted in Asia on rheumatologists and patients with moderate-to-severe RA who experienced IMF for ≥3 mornings a week. Participants underwent comprehensive face-to-face interviews using structured questionnaires. Results Sixty physicians and 300 patients from Hong Kong, Philippines, Singapore, South Korea, and Taiwan were surveyed. Rheumatologists estimated that two-thirds of patients with RA experienced IMF and believed that the prevalence of IMF increased with RA severity (present in 42%, 73%, and 87% of patients with mild, moderate, and severe disease, respectively). Patients’ survey revealed that, on an average, patients with RA experienced IMF 5 days a week for 2 h each day. Thirty-eight percent of patients with RA considered a reduction in morning stiffness as an important treatment goal, but this was agreed by only 3% of rheumatologists. Only 22% of rheumatologists modified the treatment regimen specifically for IMF. Physicians considered prednisolone and other glucocorticoids (GCs) to be the most effective medication for the treatment of IMF. Fifty-one percent of patients with RA did not find their current medication effective in relieving IMF, and as a result, they reported negative emotions such as frustration, defeat, and anger, and 56% had missed work because of this symptom. Conclusions IMF is prevalent in RA and significantly affects patients’ quality of life (QoL). A higher proportion of patients compared to physicians view the reduction of morning stiffness as an important goal. More should be done to address the dissonance between physicians’ and patients’ views on IMF.

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Reevaluation of the Role of Duration of Morning Stiffness in the Assessment of Rheumatoid Arthritis Activity

Abstract: MS duration has a moderate correlation with RA disease activity. Assessment of MS duration may be clinically helpful in patients with low RAPID3 scores.

Cited by 60 publications

References 28 publications

Sexual Health and Intimate Relationships in Rheumatoid Arthritis

Sexual Health and Intimate Relationships in Rheumatoid Arthritis

Assessment of Rheumatoid Arthritis in Clinical Care

Dissonance between physicians’ and patients’ perspectives on managing impaired morning function in Asian patients with rheumatoid arthritis

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