Reference Charts for Fetal Corpus Callosum Length

Cignini, Pietro; Padula, Francesco; Giorlandino, Maurizio; Brutti, Pierpaolo; Alfó, Marco; Giannarelli, Diana; Mastrandrea, Maria Luisa; D’Emidio, Laura; Vacca, Lorenzo; Aloisi, Alessia; Giorlandino, Claudio

doi:10.7863/ultra.33.6.1065

Cited by 53 publications

(46 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Fetal neurosonography is the method of choice for in-utero brain imaging, and the normal CC and its anomalies are being visualized with increased frequency particularly during the second half of pregnancy [13][14][15][16][17][18]20,29 ; some of these studies include a limited number of fetuses only as early as 16-17 weeks. 13,14 Current understanding is that it is extremely difficult to visualize the CC before 18 weeks of pregnancy mainly due to technical limitations when performing fetal US before this time.…”

Section: Discussionmentioning

confidence: 99%

“…Fetal ultrasound (US) studies addressed the development of the CC by direct visualization only at a more advanced gestational age, when the CC development has completed [13][14][15][16][17][18] ; but until now US studies analyzing the dynamics of its early development were not possible mainly due to resolution limitations. 19,20 Previously, it was suggested that by using transabdominal US with color Doppler, showing blood flow along the midsagittal image, assuming to represent the pericallosal arteries, can be used as an indirect indication to the presence of some portions of the corpus callosum or as a marker for a CC pathology.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The early pattern of human corpus callosum development: A transvaginal 3D neurosonographic study

et al. 2020

View full text Add to dashboard Cite

Objective To provide an in‐vivo description of early corpus callosum (CC) development. Methods We reviewed 3D US volumes acquired transvaginally (TVUS) through the anterior fontanelle, between 14 to 17 weeks. The following landmarks were recognized: tela‐choroidea (TC), foramina of Moro, early CC and the evolving cavum septi pellucidi. The following measurements were taken: total, anterior and posterior sections, and height of the CC (referenced to the anterior TC border). All measurements were correlated to both the gestational age and the transverse cerebellar diameter (TCD). Results Eighty nine volumes were included in the study (mean 15.1 weeks ± 0.84, TCD range, 13.1‐18.4 mm) with high inter and intra observer correlation of the measurements. We found high correlation between CC length and height, and TCD. The anterior segment of the CC appear earlier than the posterior one, and growth continues bi‐directionally. Initially, the posterior elongation is significantly larger than the anterior one. Association of all CC measurements with TCD remained significant when co‐varying for maternal age and fetal sex. Conclusions imaging the fetal CC is feasible from 14 weeks by TVUS, by following the suggested insonation approach. The early CC develops bi‐directionally, and the posterior elongation is more significant than the anterior one.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The early pattern of human corpus callosum development: A transvaginal 3D neurosonographic study

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Anomalies of the CC included absent, short, thick or apparently normal but stretched CC. The CC was defined as short when length measurement was <3rd centile using reference curves by Cignini et al11 A short CC was then classified as complete (Figure 1) or incomplete (Figure 2); when incomplete, the missing part was noted (rostrum, genu, body, splenium). A CC was defined as thick when ≥3 mm at the mid‐coronal plane as described by Achiron and Achiron 12.…”

Section: Methodsmentioning

confidence: 99%

New insights in cerebral findings associated with fetal myelomeningocele: a retrospective cohort study in a single tertiary centre

Maurice

Garel

et al. 2020

BJOG

View full text Add to dashboard Cite

Objective To investigate cerebral anomalies other than Chiari type 2 malformation in fetuses with myelomeningocele (MMC). Design A retrospective cohort study in a single tertiary centre. Setting A review of associated cerebral anomalies in cases with prenatal diagnosis of myelomeningocele. Population Seventy cases of fetal myelomeningocele. Methods Ultrasound and MRI images were blindly reviewed. Postnatal imaging and results of the postmortem results were also reviewed. The association between cerebral anomalies and the following ultrasound findings was measured: level of the defect, ventriculomegaly, microcephaly and fetal talipes. Main outcome measures A microcephaly was observed in 32/70 cases (46%) and a ventriculomegaly was observed in 39/70 cases (56%). Other cerebral anomalies were diagnosed in 47/70 (67%). Results Other cerebral anomalies were represented by 42/70 cases with abnormal CC (60%), 8/70 cases with perinodular heterotopia (PNH; 11%), 2/70 cases with abnormal gyration (3%). MRI performed only in fetal surgery cases confirmed the ulltrasound findings in all cases and provided additional findings in two cases (PNH). Risk ratios of fetal cerebral anomalies associated with MMC did not reach significance for microcephaly, ventriculomegaly, talipes or the level of the defect There was an overall good correlation between pre-and postnatal findings with a Kappa value of 0.79 [95% CI 0.57-1] and 82% agreement. Conclusion Fetal brain anomalies other than Chiari type 2 malformation are frequently observed in fetuses with myelomeningocele, predominantly represented by CC anomalies. Whether these associated cerebral anomalies have an impact on selecting cases eligible for fetal surgery needs further evaluation.

show abstract

“…[9] Several different CC nomograms have been presented in the literature. [10][11][12][13][14][15][16][17] The fact that the values presented in these nomograms are very different from each other emphasizes that different regions/populations will have different values. The different results obtained even in studies with similar measurement techniques reveal the necessity for populations to create their own nomograms.…”

confidence: 97%

“…[24][25][26] Table 4 shows CC nomograms prepared by different researchers. [10][11][12][13][14][15][16][17] As seen in the table, there are societal differences among such studies ( Table 4). This situation not only reveals the necessity for different populations to develop their own nomograms, but it also requires questioning of the diagnostic accuracy of nomograms.…”

mentioning

confidence: 99%

Nomogram for second trimester corpus callosum measurements: are nomograms reliable?

Alemdaroğlu¹,

Baran²,

Durdağ³

et al. 2020

Perinatal J

View full text Add to dashboard Cite

Objective: To define normal values of second trimester fetal corpus callosum (CC) length and width in a low-risk population and to compare the presented nomograms to those in the literature. Methods: The prenatal records of singleton fetuses who underwent second trimester anomaly screening at 18.0–22.0 weeks of pregnancy were retrospectively analyzed for CC width and length. A total of 710 fetuses, whose anomaly scans were completely normal, were included in the study. The correlations between CC and biparietal diameter (BPD), head circumference (HC) and gestational age (GA) were evaluated. Results: At 18.0–22.0 weeks of pregnancy, the mean CC length was 19.7±2.8 mm, while the mean CC thickness was 1.98±0.4 mm. In assessment of the correlations between the CC length and thickness values and the HC, BPD and GA values by Pearson’s correlation coefficient, there was a stronger correlation between the CC length measurements and the BPD, HC and GA values (r=0.233 vs r=0.505, p<0.001). Conclusion: Assessment of the presence of corpus callosum as well as its length and thickness during routine fetal anomaly evaluation may be important owing to the relationship between corpus callosum measurements and certain neurological disorders. Studies indicate that populations should create their own nomograms due to different values reported in the literature.

show abstract

Reference Charts for Fetal Corpus Callosum Length

Abstract: This work provides new quantile-based reference charts for corpus callosum length measurements that may be useful for diagnosis of congenital corpus callosum anomalies in fetal life.

Cited by 53 publications

References 44 publications

The early pattern of human corpus callosum development: A transvaginal 3D neurosonographic study

The early pattern of human corpus callosum development: A transvaginal 3D neurosonographic study

New insights in cerebral findings associated with fetal myelomeningocele: a retrospective cohort study in a single tertiary centre

Nomogram for second trimester corpus callosum measurements: are nomograms reliable?

Contact Info

Product

Resources

About