Reference distributions for the positive acute phase proteins, α1‐acid glycoprotein (orosomucoid), α1‐antitrypsin, and haptoglobin: A comparison of a large cohort to the world’s literature

Ritchie, Robert F.; Palomaki, Glenn E.; Neveux, Louis M.; Navolotskaia, Olga

doi:10.1002/1098-2825(20001212)14:6<265::aid-jcla3>3.3.co;2-1

Cited by 8 publications

(8 citation statements)

References 36 publications

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“…SERPINA-1 is synthesized by the liver, macrophages neutrophils and also by trophoblast 41. Increases in serum SERPINA-1 occur in diseases such as rheumatoid arthristis, vasculitis, infections and other diseases associated with an inflammatory component 42. Interestingly, studies have shown that even minor increases in levels of serum SERPINA-1 are associated with development of arterial hypertension and an increased risk of cardiovascular disease 43, 44.…”

Section: Discussionmentioning

confidence: 99%

Proteomic profiling of urine identifies specific fragments of SERPINA1 and albumin as biomarkers of preeclampsia

Buhimschi

Zhao

Funai

et al. 2008

American Journal of Obstetrics and Gynecology

127

105

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Objective The cause of preeclampsia remains unknown and the diagnosis can be uncertain. We used proteomic-based analysis of urine to improve disease classification and extend the pathophysiological understanding of preeclampsia. Study design Urine samples from 284 women were analyzed by mass spectrometry-based proteomics (SELDI). In the exploratory phase, 59 samples were used to extract the proteomic fingerprint characteristic of severe preeclampsia requiring mandated delivery and develop a diagnostic algorithm. In the challenge phase we sought to prospectively validate the algorithm in 225 women screened for a variety of high and low-risk conditions, including preeclampsia. Of these, 19 women were followed longitudinally throughout pregnancy. Presence of biomarkers was interpreted relative to clinical classification, need for delivery and other urine laboratory measures (ratios of protein-to-creatinine and soluble fms-like tyrosine kinase-1-to-placental growth factor). In the translational phase biomarker identification by tandem mass spectrometry and validation experiments in urine, serum and placenta were employed to identify, quantify and localize the biomarkers or related proteins. Results We report that women with preeclampsia appear to present a unique urine proteomic fingerprint which predicts preeclampsia in need for mandated delivery with highest accuracy. This characteristic proteomic profile also has the ability to distinguish preeclampsia from other hypertensive or proteinuric disorders in pregnancy. Pregnant women followed longitudinally who developed preeclampsia displayed abnormal urinary profiles >10 weeks prior to clinical manifestation. Tandem mass spectrometry followed by de-novo sequencing identified the biomarkers as non-random cleavage products of SERPINA-1 and albumin. Of these, the 21-aminoacid C-terminus fragment of SERPINA-1 was highly associated with severe forms of preeclampsia requiring early delivery. In preeclampsia, increased and aberrant SERPINA-1 immunoreactivity was found in urine, serum and placenta where it localized predominantly to placental villi and placental vascular spaces adherent to the endothelium. In addition, significant perivascular deposits of misfolded SERPINA-1 aggregates were exclusively identified in preeclamptic placentas. Conclusion Proteomics-based characterization of urine in preeclampsia identified a proteomic fingerprint composed of SERPINA-1 and albumin fragments which can accurately diagnose preeclampsia and shows promise to discriminate it from other hypertensive proteinuric diseases. These findings provide insight into a novel pathophysiological mechanism of preeclampsia related to SERPINA-1 misfolding which may offer new therapeutic opportunities in the future.

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Section: Discussionmentioning

confidence: 99%

Proteomic profiling of urine identifies specific fragments of SERPINA1 and albumin as biomarkers of preeclampsia

Buhimschi

Zhao

Funai

et al. 2008

American Journal of Obstetrics and Gynecology

127

105

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“…Briefly, the methods used to search for relevant publication were the same as for the previous studies (1)(2)(3)(4)(5)(6) with the key-word headings and the analyte specific terms using PubMed (http://www.ncbi.nlm.nih. gov/PubMed) and MEDLINE CD-ROM searches (OVID Technologies, New York, NY).…”

Section: Materials and Methods Identification Of Published Reference Datamentioning

confidence: 99%

Reference distributions for apolipoproteins AI and B and B/AI ratios: comparison of a large cohort to the world's literature

Ritchie

Palomaki

Neveux

et al. 2006

Clinical Laboratory Analysis

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Limiting the clinical utility of apolipoproteins AI (apo AI) and B (apo B) and the apo B/AI ratios until the last decade has been the lack of satisfactory methods for quantifying serum levels and credible reference materials. Great technological strides have been made in the last few years. The remaining barrier to more relevant and cost-effective use of serum protein data for diagnosis and prognosis has been the availability of widely recognized reliable reference intervals from birth to old age for both males and females. A total of 82 publications reporting reference intervals have been identified that meet most of the same inclusion criteria used in our prior six studies. These have been analyzed statistically and compared to similar studies, i.e., sufficient number, listed subject criteria, method, and reference material, in general terms. Published smaller studies with constrained age ranges, agree on average with our large series of life-long reference intervals that range from less than one year to over 80 years. This study was performed to assess the degree of agreement between smaller reference interval studies to our large population analysis. This meta-analysis provides support and reassurance that many of the smaller reference intervals published previously fall within reasonable limits of out large population.

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“…SERPIN1 increases in several diseases with an inflammatory component [43]. Even minor increases of this protein are associated with arterial hypertension and higher risk of cardiovascular disease [44], both related to IUGR at adult ages.…”

Section: Biological Significance Of the Proteins Characteristic Of Iumentioning

confidence: 99%

Alterations of protein expression in serum of infants with intrauterine growth restriction and different gestational ages

Ruis-González

Cañete

Gomez-Chaparro³

et al. 2015

Journal of Proteomics

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Reference distributions for the positive acute phase proteins, α1‐acid glycoprotein (orosomucoid), α1‐antitrypsin, and haptoglobin: A comparison of a large cohort to the world’s literature

Cited by 8 publications

References 36 publications

Proteomic profiling of urine identifies specific fragments of SERPINA1 and albumin as biomarkers of preeclampsia

Proteomic profiling of urine identifies specific fragments of SERPINA1 and albumin as biomarkers of preeclampsia

Reference distributions for apolipoproteins AI and B and B/AI ratios: comparison of a large cohort to the world's literature

Alterations of protein expression in serum of infants with intrauterine growth restriction and different gestational ages

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