Reference Intervals and Decision Limits

Friedrichs, Kristen R.; Jensen, A. L.; Kjelgaard‐Hansen, Mads

doi:10.1002/9781119500537.ch140

Cited by 1 publication

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“…Many textbooks and reviews state reference intervals for equine APPs. But reference intervals can only be shared across laboratories using the exact same methodology 53 . Each laboratory must therefore establish its own reference intervals, preferably de novo, or by transference using a small number of samples according to established guidelines 54 …”

Section: Methods For Measuring Saamentioning

confidence: 99%

Use of serum amyloid A in equine medicine and surgery

Jacobsen

2022

Veterinary Clinical Pathol

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Serum amyloid A (SAA) has become an indispensable part of the management of equine patients in general practice and specialized hospital settings. Although several proteins possess acute phase properties in horses, the usefulness of SAA exceeds that of other acute phase proteins. This is due to the highly desirable kinetics of the equine SAA response. SAA concentrations exhibit a rapid and pronounced increase in response to inflammation and a rapid decline after the resolution of inflammation. This facilitates the detection of inflammatory disease and real‐time monitoring of inflammatory activity. SAA may be used in all stages of patient management: (1) before diagnosis (to rule in/rule out inflammatory disease), (2) at the time of diagnosis (to assess the severity of inflammation and assist in prognostication), and (3) after diagnosis (to monitor changes in inflammatory activity in response to therapy, with relapse of disease, or with infectious/inflammatory complications). By assessing other acute phase reactants in addition to SAA, clinicians can succinctly stage inflammation. White blood cell counts and serum iron concentration change within hours of an inflammatory insult, SAA within a day, and fibrinogen within 2–3 days; the interrelationship of these markers thus indicates the duration and activity of the inflammatory condition. Much research on the equine SAA response and clinical use has been conducted in the last decade. This is the prerequisite for the evidence‐based use of this analyte. However, still today, most published studies involve a fairly low number of horses. To obtain solid evidence for use of SAA, future studies should be designed with larger sample sizes.

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Section: Methods For Measuring Saamentioning

confidence: 99%

Use of serum amyloid A in equine medicine and surgery

Jacobsen

2022

Veterinary Clinical Pathol

View full text Add to dashboard Cite

show abstract

Reference Intervals and Decision Limits

Cited by 1 publication

References 37 publications

Use of serum amyloid A in equine medicine and surgery

Use of serum amyloid A in equine medicine and surgery

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