Reference intervals and sources of variation of pressure pain threshold for quantitative sensory testing in a Japanese population

Suzuki, Hitomi; Tahara, Shu; Mitsuda, Mao; Funaba, Masahiro; Fujimoto, Kazuhiro; Ikeda, Hironori; Izumi, Hironori; Yukata, Kiminori; Seki, Kazushige; Uranami, Kota; Nishida, Norihiro; Sakai, Takashi

doi:10.21203/rs.3.rs-2586639/v1

Cited by 1 publication

(3 citation statements)

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“…While PPT is not directly linked to musculoskeletal pathology, it provides valuable insight into a patient's perception of local pain responses. Previous research has confirmed that patients with chronic LBP exhibit lower PPT 11 and that PPT can identify patients with and without LBP 16 .…”

Section: Discussionmentioning

confidence: 87%

“…When assessing PPT in the lumbar region, research indicates no discernable sex-based variances in healthy individuals but observes differences in males and females with LBP. When measuring PPT in the lumbar spine of healthy Japanese subjects (mean PPT ≈530 kPa), there were no sex-based differences in PPT values from the lumbar spine 16 . PPT values from the lumbar spine for healthy subjects from Brazil also reported no differences in males and females (mean PPT ≈350 kPa; mean age: 47-51 years; p = 0.3, n = 12-18 per group) 17 .…”

Section: Discussionmentioning

confidence: 87%

“…Pain sensitivity can be quantified by measuring the pressure pain threshold (PPT), which represents the minimum pressure required to induce pain. Notably, sex-based differences in PPT have not been reported in the lumbar region of healthy subjects 16 .…”

Section: Introductionmentioning

confidence: 94%

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Sex-Based Differences in Biomechanical Function for Chronic Low Back Pain and how it Relates to Pain Experience

Archibeck,

Strigo,

Scheffler

et al. 2024

Preprint

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This study examined sex-based differences in biomechanical function and pain experience of individuals with chronic low back pain (LBP). The significant variability in biomechanical function among patients with chronic LBP underscores the importance of developing a novel mathematical method to quantify full body movement, rather than relying on individual parameters from biomechanical analyses. This method was used to examine a patient-specific factor, biological sex, that may inform motion heterogeneity among LBP patients. The results highlighted significant biomechanical sex-based differences in patients with LBP during the sit-to-stand dynamic transition, which was largely driven by variations in trunk movement. Males showed increased biomechanical impairment compared to females, although there was no sex-based difference in total time. Further, measuring pressure pain threshold highlighted lower pain sensitivity in males compared to females. There was a weak but significant negative association between pressure pain thresholds and biomechanical function for males, while females lacked an association. Possible explanations include reduced interoceptive awareness or increased kinesiophobia in males, which may influence movement patterns. This research is an initial step in uncovering the complex relationship between patient-specific factors influencing LBP disability, laying the groundwork for further exploration, and paving the way for improving outcomes with patient-specific treatments.

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Section: Discussionmentioning

confidence: 87%

Section: Discussionmentioning

confidence: 87%