Reference intervals for brain natriuretic peptide in healthy newborns and infants measured with an automated immunoassay platform

Abstract

According to this data, our study indicates that at least two reference intervals should be used for newborns and infants. The first, with higher BNP values for neonates in the first week of extra-uterine life, and the other, with lower BNP values for infants aged 2 weeks to 12 years.

Mid-regional-pro-adrenomedullin plasma levels are increased in obese adolescents

“…BNP and NTproBNP plasma levels resulted in normal value range [30,31] and are similar in both controls and obese children ( Table 2). …”

B-Type Natriuretic Peptide: Biomarker of Persistent Pulmonary Hypertension of the Newborn?

“…BNP concentrations have been shown to rise at birth and then slowly fall after the initial week to lower levels. 15,16 Other factors such as sepsis, hypoxic-ischemic encephalopathy, and intrauterine growth restriction have been shown to be associated with an elevation in BNP concentrations in small studies or older populations. 17 BNP levels in our study were all done within the first 5 days of life in term neonates.…”

Reference values and the journal: why the past is now present

“…Some articles also dealt with statistical procedures suited to defi ne reference values (19) and the appropriate use of existing interlaboratory database for the same purpose (20) . Other articles have explored the importance to improve our knowledge on the reference values of " old " parameters such as blood gases (21) as well as of some new biomakers, throughout different ages (22,23) .…”