Reference intervals of serum lipids in the second and third trimesters of pregnancy in a Caucasian cohort: the LIFE Child study

Dathan-Stumpf, Anne; Vogel, Mandy; Jank, A; Thiery, Joachim; Kieß, Wieland; Stepan, Holger

doi:10.1007/s00404-019-05342-2

Cited by 16 publications

(18 citation statements)

References 26 publications

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“…Increasing oestrogen levels during pregnancy are thought to enhance synthesis of total cholesterol and LDL-C by about 30-50% [5][6][7] with the absolute increase higher in individuals with FH [8]. In addition to the rise in LDL-C levels there, is an increased proportion of smaller more atherogenic LDL-C. Triglyceride levels may treble and there is also a rise in HDL-C levels.…”

Section: Changes In Plasma Lipids During Pregnancymentioning

confidence: 99%

Management of familial hypercholesterolemia in pregnancy

Graham

Raal

2021

Current Opinion in Lipidology

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Purpose of review To highlight quandaries and review options for the management of familial hypercholesterolemia (FH) during pregnancy. Recent findings Women with FH face barriers to effective care and consequently face significant disease related long term morbidity and mortality. Pregnancy includes major maternal physiological changes resulting in exacerbation of maternal hypercholesterolemia compounded by the current practice of cessation or reduction in the dose of lipid-lowering therapy during pregnancy and lactation that may impact short and long term cardiac morbidity and mortality. Although lipoprotein apheresis is the treatment of choice for high- risk FH patients, reassuring safety evidence for the use of statins during pregnancy is mounting rapidly. However, it will be some time before subtle effects on the development of the offspring can be definitively excluded. Women with homozygous FH or with an established atherosclerotic vessel or aortic disease should be offered therapy with statins during pregnancy if lipoprotein apheresis is not readily available. Pregnancy outcomes tend to be favourable in women with FH. We have reviewed the currently available evidence regarding the risks and benefits of treatment options for FH during pregnancy.

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Section: Changes In Plasma Lipids During Pregnancymentioning

confidence: 99%

Management of familial hypercholesterolemia in pregnancy

Graham

Raal

2021

Current Opinion in Lipidology

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“…19 ) whereas the most prominent change in TG levels occurred in the third semester (2.5 to 2.7fold increase in comparison with non-pregnant women) (ref. 20,21 ). This suggests that hypertriglyceridaemia occurs earlier in pregnancy in women with GDM (ref.…”

Section: Hslmentioning

confidence: 99%

Changes in serum lipid levels during pregnancy in women with gestational diabetes. A narrative review

Cibičková¹,

Schovánek²,

Karásek³

2021

BIOMED PAP

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We review current knowledge on lipid metabolism changes during pregnancy with special focus on changes in gestational diabetes. In physiological pregnancy, total plasma cholesterol, triglyceride and HDL-cholesterol level rises, the atherogenic index (LDL-cholesterol / HDL-cholesterol remains unchanged. Compared with healthy women, women with GDM show more pronounced signs of mixed dyslipidaemia -increased levels of triglyceride, changes in cholesterol and lipoprotein concentrations with a shift towards greater small dense LDL subtractions, which is typical for insulin resistance states. Dyslipidaemia, particularly hypertriglyceridemia, is thought to be one of the key drivers of foetal macrosomia and that is why measurements of plasma lipids may be valuable in detecting the metabolic abnormality in GDM and in predicting foetal outcome. Dyslipidaemia in GDM is seen as proatherogenic and potentially harmful for the baby and therefore it should be monitored more carefully.

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“…These results many have clinical and research application, since even when different publications analyzed lipid percentiles in pregnancy, no percentiles for PP were reported. Furthermore, the contribution of nutritional status in these percentiles has not been reported [39][40][41].…”

Section: Lipid Levels According To Nutritional Statusmentioning

confidence: 98%

Revisiting weight gain during gestation: body mass index and weight gain are associated with increased maternal cholesterol levels and higher risk of maternal supraphysiological hypercholesterolemia

Contreras-Duarte,

Moya,

Parra

et al. 2024

Preprint

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Background Total cholesterol (TC) and low-density lipoproteins (LDL) increase during pregnancy, in order to ensure fetal development. However, some women present maternal supraphysiological hypercholesterolemia (MSPH), or lipid levels over the 75th percentile, in the third trimester of pregnancy (T3). Despite this condition being associated with vascular dysfunction in the mother and the offspring, clinical reference values for lipid levels in pregnancy, and the impact of nutritional status on lipid profile – from pre-gestational (PG) until postpartum period (PP) – or on the onset of MSPH are unknown. Aim To determine if lipid levels at PG, pregnancy, and PP are influenced by maternal nutritional status, including body mass index (BMI) and weight gain during pregnancy (WG), and if these factors are associated with MSPH. Methods This study included data from 650 women categorized as normal weight (NW), overweight (OW), and with obesity (OB), according to the nutritional status, considering the BMI at T1. Lipid profiles (TC, LDL, HDL, and triglycerides (TG)) were analyzed at PG, T1, T2, T3, and PP. The percentiles for the different lipids and nutritional status were estimated. Correlations, and linear and logistic regressions were performed, considering lipids and weight parameters. Estimated probabilities for MSPH were also calculated. Results All women in our sample presented increased TC, LDL, and TG at T2, T3, and PP, in comparison to PG. Regarding nutritional status, women with OB presented reduced TC and LDL levels at T3 compared to NW women. TC and LDL at T3 were negatively correlated and associated with BMI at T3, while they were positively correlated and associated with WG. The logistic regression showed that WG is positively associatd with MSPH. Furthermore, the increase in WG is associated with an increased estimated probability for a woman having MSPH, and reaches 68.7% for a 30-kg WG. Conclusion The TC and LDL levels at T3 were directly related to weight parameters, and higher WG increased the risk for MSPH.

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Reference intervals of serum lipids in the second and third trimesters of pregnancy in a Caucasian cohort: the LIFE Child study

Cited by 16 publications

References 26 publications

Management of familial hypercholesterolemia in pregnancy

Management of familial hypercholesterolemia in pregnancy

Changes in serum lipid levels during pregnancy in women with gestational diabetes. A narrative review

Revisiting weight gain during gestation: body mass index and weight gain are associated with increased maternal cholesterol levels and higher risk of maternal supraphysiological hypercholesterolemia

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