Reference Point Indentation

Díez-Pérez, Adolfo; Farr, Joshua N.

doi:10.1002/9781119266594.ch36

Cited by 3 publications

(2 citation statements)

References 41 publications

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“…Complementary information on bone status can be obtained with microindentation, a minimally invasive technique able to measure micromechanical bone properties with parameters related to stiffness, material strength, and tissue elements (collagen maturity, non-collagen proteins, osteon characteristics, hydration, microdamage and microporosity) [27]. The test involves pressing a hard tip, with a known force, into the specific bone region of interest, measuring the hardness of the contact area on a microscopic scale; the deeper is the indentation, the less resistant is bone.…”

Section: Why We Need To Perform Bone Biopsy In Ckd Patientsmentioning

confidence: 99%

“…To date, the microindentation data, available from the literature, are still unclear and its role in prediction of fractures is not fully established. Further research, also including CKD patients, is needed to compare this technology with other mechanical testing methods and to correctly determine its power to identify high fracture risk patients [27,30].…”

Section: Why We Need To Perform Bone Biopsy In Ckd Patientsmentioning

confidence: 99%

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Time for Revival of Bone Biopsy with Histomorphometric Analysis in Chronic Kidney Disease (CKD): Moving from Skepticism to Pragmatism

et al. 2022

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Bone Biopsy (BB) with histomorphometric analysis still represents the gold standard for the diagnosis and classification of different forms of renal osteodystrophy. Bone biopsy is the only technique able to provide comprehensive information on all bone parameters, measuring static and dynamic parameters of turnover, cortical and trabecular microarchitecture, and mineralization defects. In nephrological practice, bone biopsy yields relevant indications to support therapeutic choices in CKD, heavily impacting the management and prognosis of uremic patients. Unfortunately, the use of bone biopsy has decreased; a lack of expertise in performing and interpreting, perceived procedure invasiveness and pain, and reimbursement issues have all contributed to this decline. Nevertheless, both bone biomarkers and instrumental images cannot be considered reliable surrogates for histological findings, being insufficiently accurate to properly evaluate underlying mineral and bone disorders. This is a multidisciplinary position paper from the Nephrology and Osteoporosis Italian Scientific Societies with the purpose of restating the role of bone biopsy in CKD patient management and of providing strong solutions to allow diffusion of this technique in Italy, but potentially also in other countries. The Italian approach through the optimization and standardization of bone biopsy procedure, the construction of the Italian Hub and Spoke network, and a request for adjustment and national homogenization of reimbursement to the Italian Health Ministry has led the way to implement bone biopsy and to improve CKD patient management and prognosis.

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Section: Why We Need To Perform Bone Biopsy In Ckd Patientsmentioning

confidence: 99%

Section: Why We Need To Perform Bone Biopsy In Ckd Patientsmentioning

confidence: 99%

Time for Revival of Bone Biopsy with Histomorphometric Analysis in Chronic Kidney Disease (CKD): Moving from Skepticism to Pragmatism

et al. 2022

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Treatments of osteoporosis increase bone material strength index in patients with low bone mass

et al. 2020

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Effects on bone material properties of two-year antiosteoporotic treatment were assessed using in vivo impact microindentation (IMI) in patients with low bone mineral density (BMD) values. Antiresorptive treatment, in contrast to vitamin D ± calcium treatment alone, induced BMD-independent increases in bone material strength index, measured by IMI, the magnitude of which depended on pretreatment values. Introduction Bone material strength index (BMSi), measured by IMI in vivo, is reduced in patients with fragility fractures, but there is no information about changes in values during long-term therapy. In the present study, we assessed changes in BMSi in patients receiving antiosteoporotic treatments for periods longer than 12 months. Methods We included treatment-naive patients with low bone mass who had a BMSi measurement with OsteoProbe® at presentation and consented to a repeat measurement after treatment. Results We studied 54 patients (34 women), median age 58 years, of whom 30 were treated with bisphosphonates or denosumab (treatment group) and 24 with vitamin D ± calcium alone (control group). There were no differences in clinical characteristics between the two groups with the exception of a higher number of previous fragility fractures in the treatment group. Baseline hip BMD and BMSi values were lower in the treatment group. After 23.1 ± 6.6 months, BMSi increased significantly in the treatment group (82.4 ± 4.3 vs 79.3 ± 4.1; p < 0.001), but did not change in the control group (81.5 ± 5.2 vs 82.2 ± 4.1; p = 0.35). Changes in BMSi with antiresorptives were inversely related with baseline values (r = − 0.43; p = 0.02) but not with changes in BMD. Two patients in the control group with large decreases in BMSi values sustained incident fractures. Conclusion In patients at increased fracture risk, antiresorptive treatments induced BMD-independent increases in BMSi values, the magnitude of which depended on pretreatment values.

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Biomechanical Basis of Predicting and Preventing Lower Limb Stress Fractures During Arduous Training

O’Leary

Rice

Greeves

2021

Curr Osteoporos Rep

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Reference Point Indentation

Cited by 3 publications

References 41 publications

Time for Revival of Bone Biopsy with Histomorphometric Analysis in Chronic Kidney Disease (CKD): Moving from Skepticism to Pragmatism

Time for Revival of Bone Biopsy with Histomorphometric Analysis in Chronic Kidney Disease (CKD): Moving from Skepticism to Pragmatism

Treatments of osteoporosis increase bone material strength index in patients with low bone mass

Biomechanical Basis of Predicting and Preventing Lower Limb Stress Fractures During Arduous Training

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