Reference Profile Correlation Reveals Estrogen-like Trancriptional Activity of Curcumin

Bachmeier, Beatrice E.; Mirisola, Valentina; Romeo, Francesco; Generoso, Luca; Esposito, Alba; Dell’Eva, Raffaella; Blengio, Fabiola; Killian, Peter H.; Albini, Adriana; Pfeffer, Ulrich

doi:10.1159/000320570

Cited by 77 publications

(46 citation statements)

References 49 publications

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“…Indeed, curcumin displaced estradiol binding to its receptors [19; unpublished observations]. In breast cancer cells, curcumin elicited gene expression profiles typical of estrogen/phytoestrogen actions [20,21]. Estradiol (akin to a hexane extract of Curcuma comosa) reduced seminal vesicle weights in mice [22].…”

Section: Discussionmentioning

confidence: 99%

Reproductive Effects of Pegylated Curcumin.

Murphy

Tang

Kirk

et al. 2011

Biology of Reproduction

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Curcumin, a polyphenol derived from the rhizome turmeric, has potential as an anticancer agent. We synthesized an amphipathic/surfactant pegylated curcumin (curcumin-PEG) designed for parenteral administration. Objectives of these investigations were to assess side-effects of a therapeutic regimen of curcumin-PEG in a preclinical model. Intraperitoneal (ip) tumor burdens were reduced in athymic female mice grafted with human SKOV-3 ovarian adenocarcinoma cells and injected intravenously (iv) with curcumin-PEG. There were no gross anatomical or histopathological effects detected in non-reproductive organs. Uteri (luminal fluid imbibition) and ovaries (decreased folliculogenesis) were affected by treatment. Curcumin-PEG ip hastened the onset of puberty in immature female mice. Live births were reduced in mature females housed with males and treated iv with curcumin-PEG; mating (vaginal plugs) was not affected. Accessory gland weights, testicular testosterone concentrations, and spermatogenesis were diminished in mature male mice following iv curcumin-PEG. Estrogenic/antiandrogenic and pregnancydisrupting effects of a water soluble/bioavailable curcumin were demonstrated.

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Section: Discussionmentioning

confidence: 99%

Reproductive Effects of Pegylated Curcumin.

Murphy

Tang

Kirk

et al. 2011

Biology of Reproduction

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“…Epigenetics appears to be the link between environment-associated diseases, nutrition and health. Nutrients can modify the epigenetic program and influence gene expression therefore controlling the intake of functional food components through diet can be powerful in preventing agerelated and other diseases including cancer [12][13][14]. It is emerging a novel view of food and metabolites, in contraposition to the classical paradigm based on the chemical conversion of food in energy and body mass.…”

Section: Non-coding Rnas (Ncrnas)mentioning

confidence: 99%

Epigenetics and Nutrition

Raganelli¹

2018

MOJFPT

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In the last few years, the idea of food and nutrition has undergone radical changes. The paradigm defining food as a simple source of energy and body mass has evolved in a novel concept, in which nutrients can exert specific functions directly linked to human health. Several edibles contain biological active compounds that influence cellular, metabolic and physiologic processes. A variety of dietary compounds have been associated with specific effects and mechanisms of action, often involving epigenetic modifications and gene expression changes. DNA methylation, histone modifications and the activity of non-coding RNAs control chromatin condensation state, allowing the interaction of DNA with transcription factors required for transcriptional activation. Some metabolites act as substrates of key chromatin remodeling factors or compete with other substrates, influencing their catalytic activity. The quantity and quality of macronutrients assumed by diet offers a possible mechanism of interaction between the body and its environment. A number of biological compounds are known to interact with the epigenome. Folic acid, methionine, choline and other B group vitamins are an important source of one-carbon groups required for methylation of histone proteins and non-histone chromatin remodeling factors. Other compounds like polyphenols, including resveratrol, curcumin and quercetin exert a multitude of biological activities. Furthermore, these compounds can influence DNA methyltransferases, the enzymes responsible for DNA methylation. Dietary interventions aimed to maximize potential health benefits derived from nutrition have shown that dietary regimens can be very effective for prevention and treatment of several diseases. Calorie restriction, protein restriction, fast mimicking diets or time restricted feeding have shown to have significant effects on health. Food quality is crucial for the activity of biological compounds and their potential health benefits. Diets rich in animal-derived proteins are associated with higher rates of mortality compared to diets based on plant-derived proteins.

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“…In most studies high concentrations of the compounds are used in order to obtain measurable effects. We have recently shown that the phytochemicals curcumin, enterolactone and quercetin have estrogenic effects on gene transcription even at low, physiological concentrations that become evident by the correlation analysis of estradiol and phytoestrogen induced gene expression profiles [37]. …”

Section: Phytoestrogensmentioning

confidence: 99%

“…After the advent of genomic technologies, nearly a decade ago, the capability of a molecule to produce estrogenic effects in vitro is usually evaluated by gene expression profiling [37, 96-99]. This analysis, based on the comparison between the gene expression changes induced by E2 and by the substance to be tested, has shown that E2 regulates the expression of hundreds of genes [99, 100].…”

Section: Effects Of Phyto- and Xenoestrogens On Human Breast Tissuementioning

confidence: 99%

Combating Malaria with Plant Molecules: A Brief Update

Negi¹,

Gupta²,

Hamid

2013

CMC

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Observations on the role of ovarian hormones in breast cancer growth, as well as interest in contraception, stimulated research into the biology of estrogens. The identification of the classical receptors ERα and ERβ and the transmembrane receptor GPER and the resolution of the structure of the ligand bound to its receptor established the principal molecular mechanisms of estrogen action. The presence of estrogen-like compounds in many plants used in traditional medicine or ingested as food ingredients, phytoestrogens, as well as the estrogenic activities of many industrial pollutants and pesticides, xenoestrogens, have prompted investigations into their role in human health. Phyto- and xenoestrogens bind to the estrogen receptors with a lower affinity than the endogenous estrogens and can compete or substitute the hormone. Xenoestrogens, which accumulate in the body throughout life, are believed to increase breast cancer risk, especially in cases of prenatal and prepuberal exposure whereas the role of phytoestrogens is still a matter of debate. At present, the application of phytoestrogens appears to be limited to the treatment of post-menopausal symptoms in women where the production of endogenous estrogens has ceased. In this review we discuss chemistry, structure and classification, estrogen signaling and the consequences of the interactions of estrogens, phytoestrogens and xenoestrogens with their receptors, the complex interactions of endogenous and exogenous ligands, the evaluation of the health risks related to xenoestrogens, and the perspectives toward the synthesis of potent third generation selective estrogen receptor modulators (SERMs).

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Reference Profile Correlation Reveals Estrogen-like Trancriptional Activity of Curcumin

Cited by 77 publications

References 49 publications

Reproductive Effects of Pegylated Curcumin.

Reproductive Effects of Pegylated Curcumin.

Epigenetics and Nutrition

Combating Malaria with Plant Molecules: A Brief Update

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