Reference range evaluation of complete blood count parameters with emphasis on newer research parameters on the complete blood count analyzer Sysmex XE-2100

Sehgal, Kunal; Dadu, Tina; Choksey, Urmi; Dalal, Reeta J; Shanaz, Khodaiji J

doi:10.4103/0377-4929.118698

Cited by 12 publications

(6 citation statements)

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“…After removing 20 statistical outliers, the platelet indices of 2356 individuals (791 males and 1565 females; age range from 16 to 91 years), with all FBC parameters within the local reference ranges, were analysed on the Sysmex XN-10 analyzer. The distribution of all platelet indices was Gaussian, showing approximately normally distributed histograms and QQ plots by visual examination; hence, a parametric method (mean ± 2SD) was used to calculate the reference intervals for all platelet indices 21 …”

Section: Resultsmentioning

confidence: 99%

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Sex-divided reference intervals for mean platelet volume, platelet large cell ratio and plateletcrit using the Sysmex XN-10 automated haematology analyzer in a UK population

Ali

Gibbs

Knight

et al. 2019

Hematology, Transfusion and Cell Therapy

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Background This study aimed to define the sex-divided reference intervals for platelet indices (mean platelet volume (MPV), platelet distribution width (PDW), platelet large cell ratio (P-LCR) and plateletcrit (PCT)) on the Sysmex XN-10. Methods A total of 2376 samples were assayed for full blood count on the Sysmex XN-10 haematology analyzer. After removing the outliers, reference intervals were calculated using the mean ± 2SD. The P value 0.05 was adopted to denote statistical significance. Results There was a statistical significance ( α = 0.05) between sex-divided reference intervals for MPV ( p = 0.007), P-LCR ( p = 0.015) and PCT ( p < 0.001), thus separate reference intervals were calculated for these indices, with orientation to the sex-divisions as follows: MPV, 9.1–13.0 fL [males] and 9.2–12.8 fL [females]; P-LCR, 17.6–47.0% [males] and 17.8–47.8% [females]; and PCT, 0.16–0.35% [males] and 0.18–0.37% [females]. No significance was found between sex-divided reference intervals for the PDW ( p = 0.838), therefore a reference interval for total individuals was calculated for this platelet measurement as 9.3–17.3 fL. Conclusion This study showed comparable reference intervals, using the Sysmex XN-10, with the previous literature. It determined the need to define sex-specific reference intervals for the MPV, P-LCR and PCT, but not for the PDW. These reference intervals will allow for low and high values to be facilitated in order to do further research and guide platelet disorder management.

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Section: Resultsmentioning

confidence: 99%

“…Independent t -tests were performed to determine whether there was a statistical significance between platelet indices in males and females. The P value ≤0.05 was adopted to denote statistical significance 21 …”

Section: Methodsmentioning

confidence: 99%

Sex-divided reference intervals for mean platelet volume, platelet large cell ratio and plateletcrit using the Sysmex XN-10 automated haematology analyzer in a UK population

Ali

Gibbs

Knight

et al. 2019

Hematology, Transfusion and Cell Therapy

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“…Although the reference ranges applicable to research-related items in the XE-2100 and reference range for immature platelet fraction (IPF) in the new XN-2000 analyzer with large study population were analyzed in the previous studies [ 4 5 ], the establishment of age- and gender-specific reference ranges for all 36 routine and 57 CPD items in the new XN-2000 analyzer has not been performed. Therefore, we established age- and gender-specific reference ranges for the routine CBC and CPD items in the new Sysmex XN-2000.…”

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confidence: 99%

Establishment of Age- and Gender-Specific Reference Ranges for 36 Routine and 57 Cell Population Data Items in a New Automated Blood Cell Analyzer, Sysmex XN-2000

Park

Lee

et al. 2016

Ann Lab Med

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We established age- and gender-specific reference ranges for the 36 routine complete blood cell (CBC) and 57 cell population data (CPD) items in the Sysmex XN-2000 (Sysmex, Japan). In total, 280 peripheral blood samples were obtained from an equal number of healthy adults. Values for 36 routine items and 57 CPD items were obtained for each sample, and the results were categorized into six subgroups (N>39 in each subgroup) according to patient age (20-40, 41-60, and >60 yr) and gender (male and female), and compared with respect to age and gender differences. The majority of data items (22 of 36 routine CBC items and 44 of 57 CPD items) exhibited significant differences (P≤0.05) in their results with respect to age or gender, and several red cell-, lymphocyte-, and platelet-related data tended to decrease in women or older adults. These results provide a basis for establishing age- and gender-specific reference ranges for routine and CPD items in Sysmex XN-2000. Furthermore, these reference ranges could be used to determine clinical significance for new items of Sysmex XN-2000 in further studies.

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“…Performing many tests leads not only to increased cost for patients, but some of the tests used for detecting iron deficiency have a limited value in presence of infection and malignancy [15]. Ret-He can be used as a single, rapid, and cost-effective test for determining iron status [16][17][18]. Many studies have been conducted in the past establishing effectiveness of Ret-He in diagnosing iron deficiency in patients suffering from different disorders.…”

Section: Introductionmentioning

confidence: 99%

Reticulocyte Hemoglobin Equivalent: Diagnostic Performance in Assessment of Iron Deficiency in Patients with Hypothyroidism

Aslam

Habib

Aziz

et al. 2021

Anemia

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Introduction. Iron deficiency affects approximately 30% of the world population and is frequently encountered in hypothyroid patients. Early recognition and prompt treatment of iron deficiency in hypothyroid patients lead to a favorable outcome. The aim of this study is to prove the usefulness of reticulocyte hemoglobin equivalent (Ret-He) as a reliable and effective tool in diagnosis of iron deficiency in hypothyroid patients. Materials and Methods. 154 patients with hypothyroidism were included in the study. They were divided into 4 groups. Group 1 included 66 hypothyroid patients without iron deficiency. They were taken as controls. Group 2 included 66 hypothyroid patients with iron deficiency anemia (IDA). Group 3 included 12 hypothyroid patients with iron deficiency but without anemia (ID). Group 4 included 10 hypothyroid patients which had concomitant iron deficiency with anemia of chronic disorder (ACDC). Ret-He was measured by analyzing blood samples on System XN 350. Thyroid profile, serum ferritin, and biochemical data were measured by an automated analyzer. Statistical analysis was performed by using SPSS 23. Results. Ret-He was significantly lower with ( p < 0.001 ) in group 2 (hypothyroid patients with IDA), group 3 (hypothyroid patients with ID), and in group 4 (hypothyroid patients with ACDC) as compared to controls in group 1 (hypothyroid patients without iron deficiency). After ROC analysis area under the curve (AUC) of Ret-He for hypothyroid patients with IDA was 0.96 at cutoff 28.5 pg with sensitivity of 93% and specificity of 90%. AUC of Ret-He in the hypothyroid group with ACDC was 0.99 at cutoff 30.8 pg with sensitivity of 90% and specificity of 90%. AUC of Ret-He in hypothyroid patients with ID was 0.97 at cutoff 31.7 pg with sensitivity of 91% and specificity of 70%. Conclusion. Ret-He is a reliable, rapid, and cost-effective tool for diagnosing iron deficiency in hypothyroid patients.

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Reference range evaluation of complete blood count parameters with emphasis on newer research parameters on the complete blood count analyzer Sysmex XE-2100

Cited by 12 publications

References 0 publications

Sex-divided reference intervals for mean platelet volume, platelet large cell ratio and plateletcrit using the Sysmex XN-10 automated haematology analyzer in a UK population

Sex-divided reference intervals for mean platelet volume, platelet large cell ratio and plateletcrit using the Sysmex XN-10 automated haematology analyzer in a UK population

Establishment of Age- and Gender-Specific Reference Ranges for 36 Routine and 57 Cell Population Data Items in a New Automated Blood Cell Analyzer, Sysmex XN-2000

Reticulocyte Hemoglobin Equivalent: Diagnostic Performance in Assessment of Iron Deficiency in Patients with Hypothyroidism

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