Reference Ranges for Corpus Callosum and Cavum Septi Pellucidi Biometry on Prenatal Ultrasound: Systematic Review and Meta‐Analysis

Rosenbloom, Joshua I.; Yaeger, Lauren; Porat, Shay

doi:10.1002/jum.15905

Cited by 10 publications

(16 citation statements)

References 47 publications

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“…Different trend is depicted by area on T2WS (blue). This is a provisional file, not the final typeset article Several biometric charts of the fetal brain growth by US, including linear regressions of LCC, have been published (29,31,34,35). Also, morphometry of the fetal brain by T2WS MRI has been previously explored (32,36,37).…”

Section: Area Of the Corpus Callosummentioning

confidence: 99%

Assessment of fetal corpus callosum biometry by 3D super-resolution reconstructed T2-weighted MRI

Lamon,

de Dumast,

Dunet

et al. 2023

Preprint

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Objective: To assess the accuracy of corpus callosum (CC) and its sub-segments' biometry by super-resolution (SR) 3-dimensional fetal brain MRI in comparison to measurements in 2-dimensional or 3-dimensional ultrasonography (US) and clinical low-resolution T2-weighted MRI sequences (T2WS). Method: We performed fetal brain biometry of the overall length of the CC, the heights of its sub-segments and its area by two observers (one junior observer, obs1, and one senior pediatric neuroradiologist, obs2) in a cohort of 57 subjects (between 21 and 35 weeks of gestational age (GA), including 11 cases of partial agenesis of CC). Obs1 made measures on US, T2WS, and SR, and obs2 in T2WS and SR. Regression curves of CC biometry with GA were done. Statistical analysis of inter-modality (US vs. T2WS, US vs. SR, and T2WS vs SR) agreement for single observer (obs1) and inter-modality (US vs. T2WS, and US vs. SR) between observers (obs1 vs obs2) were also conducted. Results: Our study shows a high concordance through GA of CC measurements performed by SR in comparison with US, with a higher agreement than biometry based on T2WS clinical acquisitions. For obs1, SR measurements are highly concordant to US (except for the genu and the CC length) and helps visualizing the splenium. For obs2, SR measurements are highly concordant to US, except for the rostrum and the CC length. Rostrum and Genu (forming the anterior callosum) are the subsegments with larger variability. Regression curves by SR overlay more accurately those from the literature (by US) for the CC length, the splenium and the body than T2WS. Conclusion: Super-resolution MRI could be used in the biometrical assessment of the CC, providing measurements close to US, except for the anterior part of the CC Thanks to its 3D-visualisation capacity and improved through plane spatial resolution, it allows to perform CC biometry more frequently than on T2WS.

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Section: Area Of the Corpus Callosummentioning

confidence: 99%

Assessment of fetal corpus callosum biometry by 3D super-resolution reconstructed T2-weighted MRI

Lamon,

de Dumast,

Dunet

et al. 2023

Preprint

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“…CC length is measured on the best midsagittal plane from the anteriormost to posteriormost aspect in US and MRI 17 . Measurement of CC length by US and MRI does not yield statistically different results 18 .…”

Section: Normal Appearance Of CC In Prenatal Us and Mrimentioning

confidence: 99%

“…Measurement of CC length by US and MRI does not yield statistically different results 18 . Reference charts for fetal CC length based on gestational age can be found elsewhere 17,19 . Short CC is defined as reduced CC length, less than or equal to the first percentile 20 …”

Section: Normal Appearance Of CC In Prenatal Us and Mrimentioning

confidence: 99%

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Fetal corpus callosum abnormalities: Ultrasound and magnetic resonance imaging role

Moradi

Taherian

Tahmasebpour³

et al. 2022

J of Clinical Ultrasound

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The corpus callosum (CC) is the major interhemispheric commissure and its abnormalities include agenesis, hypoplasia, and hyperplasia. The CC anomalies are typically related to other central nervous system (CNS) or extra-CNS malformations.The antenatal diagnosis of complete CC agenesis is easy after mid-trimester by ultrasound (US) even in the axial plane. The non-visualization of cavum septum pellucidum and colpocephaly are critical signs in the axial view. More subtle findings (i.e., hypoplasia and partial agenesis) might also be recognized antenatally. In this review, the focus was given on the prenatal diagnosis of CC abnormalities in US and magnetic resonance imaging.

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“…This means that the CCA is missed prenatally in nearly half of patients, which is limited by the use of prenatal ultrasound and the pro ciency of sonographers. For evaluating brain development, prenatal ultrasound can only assess intracranial structures and morphology[10] but cannot detect functional abnormalities, including mental retardation, psychomotor development delay, and speech…”

mentioning

confidence: 99%

A Novel Mutation of NONO-Associated X-linked Syndromic Intellectual Developmental Disorder-34 in a Fetus

Huang,

Wu,

Ding

et al. 2024

Preprint

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Background The NONO gene is located on chromosome Xq13.1 and encodes a nuclear protein involved in RNA synthesis, transcriptional regulation, and DNA repair. Hemizygous loss-of-function variants in NONO reportedly cause X-linked syndromic intellectual developmental disorder-34 (MRXS34) in males. At present, there are few clinical reports related to MRXS34, and the mutation spectrum of NONO-related diseases has not been completely determined. Methods We report the case of a fetus with noncompaction cardiomyopathy, a short anteroposterior diameter of the corpus callosum and relative macrocephaly. Genotyping examination, including chromosome microarray analysis (CMA) and trio-medical exon sequencing, was performed. Results Medical exon sequencing revealed a de novo hemizygous nonsense mutation (c.214 C > T, p.Gln72Ter) in exon 4 of the NONO gene. A review of previous literature suggested that noncompaction cardiomyopathy, abnormalities of the corpus callosum, and macrocephaly are consistent phenotypes of MRXS34. Conclusion The mutation (c.214 C > T, p.Gln72Ter) in the NONO gene was present in a fetus with MRXS34. This study expands the mutation spectrum of NONO-related diseases and enlarges noncompaction cardiomyopathy, abnormalities of the corpus callosum and macrocephaly to the phenotype of MRXS34 in fetuses.

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Reference Ranges for Corpus Callosum and Cavum Septi Pellucidi Biometry on Prenatal Ultrasound: Systematic Review and Meta‐Analysis

Cited by 10 publications

References 47 publications

Assessment of fetal corpus callosum biometry by 3D super-resolution reconstructed T2-weighted MRI

Assessment of fetal corpus callosum biometry by 3D super-resolution reconstructed T2-weighted MRI

Fetal corpus callosum abnormalities: Ultrasound and magnetic resonance imaging role

A Novel Mutation of NONO-Associated X-linked Syndromic Intellectual Developmental Disorder-34 in a Fetus

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