Reference Values for Orcadian Rhythms of 98 Variables in Clinically Healthy Men in the Fifth Decade of Life

Kanabrocki, Eugene L.; Sothern, Robert B.; Scheving, Lawrence E.; Vesely, David L.; Tsai, T. H.; Shelstad, J; Cournoyer, C.; Greco, J; Mermall, Hunter L.; Ferlin, H

doi:10.3109/07420529009059156

Cited by 56 publications

(22 citation statements)

References 6 publications

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“…In this context, significant correlations between resting core temperature and LDH and between WBC and CK and LDH were registered. These findings confirmed that the presence of leucocytosis at a specific TOD could be due to the high concentrations of catecholamines (23) and to the general increase in muscle damage (34). The present study showed higher antioxidant activity in the evening and no diurnal variation for MDA.…”

Section: Discussionsupporting

confidence: 75%

“…Therefore, the authors suggest the existence of further underlying mechanisms [i.e., such as catecholamine Kanabrocki et al (23)] which can be in the origin of muscle damage response to high-intensity weightlifting exercises. Concerning the CRP, our results showed the absence of diurnal variations at resting state and immediately and 48 h after the training sessions.…”

Section: Discussionmentioning

confidence: 99%

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Relationship between biomarkers of muscle damage and redox status in response to a weightlifting training session: effect of time-of-day

et al. 2016

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The aims of the present study were to: (1) investigate the effect of a weightlifting training session and time-of-day (TOD) upon biological parameters (i.e., oral temperature, hematological, C-reactive protein (CRP), and oxidative stress) and (2) assess their possible link with muscle damage responses. Nine weightlifters (21 ± 0.5 years) performed, in a randomized order, three Olympic-Weightlifting sessions (i.e., at 08:00, 14:00, and 18:00). Blood samples were collected at rest, 3 min and 48 h after each training session. Between pre-and post-training session, ANOVA showed significant increases in oxidative stress markers at the three TODs (p < 0.01) and significant increases for creatine kinase (CK) and lactate dehydrogenase (LDH) only at 08:00 and 18:00 (p < 0.05). At rest, the results showed a significant diurnal variation for the majority of the selected parameters except for malondialdehyde (MDA), total bilirubin, and CRP with higher values observed at 18:00 (p < 0.05). After the training session, given the higher rate of increase during the morning session, these diurnal variations persisted for temperature and WBC (p < 0.01) and were suppressed for CK, LDH, uric acid (UA), catalase, and glutathione peroxidase. The main significant correlations (p < 0.001) were observed between: (1) CK and MDA (r = 0.6) and CK and UA (r = 0.66 and r = 0.82) during the morning and evening training sessions; (2) CK and CRP only during the morning session (r = 0.5); and (3) CRP and WBC during the three training sessions (r = 0.8). In conclusion, the present findings: (1) confirm that the muscle damage responses could be induced by a high level of oxidative stress and (2) suggest to avoid scheduling training sessions in the morning given the higher muscle damage, inflammatory, and oxidative responses at this TOD.

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Section: Discussionsupporting

confidence: 75%

Section: Discussionmentioning

confidence: 99%

Relationship between biomarkers of muscle damage and redox status in response to a weightlifting training session: effect of time-of-day

et al. 2016

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“…It is possible that physiology being quantified by these tests may be more dynamic than is appreciated in the clinical interpretation of their results. Although a wealth of clinical laboratory testing data exists (10)(11)(12), the circadian or physiological periodicity of many common laboratory blood tests may need additional evaluation.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of direct-to-consumer low-volume lab tests in healthy adults

Kidd¹,

Hoffman²,

Zimmerman³

et al. 2016

Journal of Clinical Investigation

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RESULTS.Theranos flagged tests outside their normal range 1.6× more often than other testing services (P < 0.0001). Of the 22 lab measurements evaluated, 15 (68%) showed significant interservice variability (P < 0.002). We found nonequivalent lipid panel test results between Theranos and other clinical services. Variability in testing services, sample collection times, and subjects markedly influenced lab results. CONCLUSION.While laboratory practice standards exist to control this variability, the disparities between testing services we observed could potentially alter clinical interpretation and health care utilization. Greater transparency and evaluation of testing technologies would increase their utility in personalized health management.

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“…It is well established that biochemical markers of cellular damage (Kanabrocki et al 1990;Rivera-Coll et al 1993;Gutenbrunner 2000), as well as WBC and their subpopulations (Haus et al 1983), are time-of-day (TOD)-dependent with acrophases generally observed in the evening. The acrophases for the quantities studied coincide with times near those of the oral temperature acrophase (Rivera-Coll et al 1993).…”

Section: Introductionmentioning

confidence: 99%

Morning-to-evening difference of biomarkers of muscle injury and antioxidant status in young trained soccer players

Hammouda

Chahed

Chtourou

et al. 2012

Biological Rhythm Research

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The aim of this study was (i) to evaluate whether homocysteine (Hcy), total antioxidant status (TAS), and biological markers of muscle injury would be affected by time-of-day (TOD) in well-trained soccer players. In a counterbalanced order, 20 soccer players participated on two different occasions between 07:00 and 08:30 h and between 17:00 and 18:30 h. Fasting blood samples were collected from a forearm vein during each session. The results showed that the values of white blood cells (WBC), neutrophils (NE), lymphocytes (LY), and monocytes (MO) are higher in the evening than the morning. Although there was no TOD effect on blood lactate (Lac) levels, significant difference was observed for urea (URE), creatinine (CRE), and blood glucose (GLC) indicating higher evening levels. Moreover, the results also showed diurnal variations of core temperature, resting Hcy levels, and all biological markers of muscle injury [i.e., aspartate aminotransferase (ASAT), creatine kinase (CK), lactate dehydrogenase (LDH)].These parameters were lowest in the morning and tended to rise throughout the day. Furthermore, biomarkers of antioxidant status [i.e., TAS, uric acid (UA), and total bilirubin (TBIL)] displayed a significant effect of TOD with higher morning levels. In conclusion, the present study confirms the diurnal variations of Hcy, selected biological markers of cellular damage, and antioxidant status in young trained soccer players. Our finding suggests the fact that muscle damage and inflammation could be more important in the evening and that antioxidant status is more efficient in the morning.

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Reference Values for Orcadian Rhythms of 98 Variables in Clinically Healthy Men in the Fifth Decade of Life

Cited by 56 publications

References 6 publications

Relationship between biomarkers of muscle damage and redox status in response to a weightlifting training session: effect of time-of-day

Relationship between biomarkers of muscle damage and redox status in response to a weightlifting training session: effect of time-of-day

Evaluation of direct-to-consumer low-volume lab tests in healthy adults

Morning-to-evening difference of biomarkers of muscle injury and antioxidant status in young trained soccer players

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