Reference values for serum creatinine in children younger than 1 year of age

Boer, Dirk P.; Rijke, Yolanda B. de; Hop, Wim C. J.; Cransberg, Karlien; Dorresteijn, Eiske M.

doi:10.1007/s00467-010-1533-y

Cited by 149 publications

(117 citation statements)

References 27 publications

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“…Children were assigned RIFLE scores during ECMO using SCr values compared with age-appropriate SCr reference values. These SCr reference values were obtained from children without kidney dysfunction daily shortly after birth and at increasing intervals thereafter (37). This method, therefore, allowed us to reliably identify various degrees of AKI during neonatal ECMO support, despite the maternal SCr influence and rapidly changing renal function after birth as well as the absence of baseline SCr concentrations, which was the case with the majority of neonates requiring ECMO.…”

Section: Discussionmentioning

confidence: 99%

“…Ultimately, for each patient, history of AKI was defined according to the maximal SCrbased RIFLE category obtained throughout ECMO: risk for kidney injury, injury to the kidney, and failure of kidney function (3). Because reliable SCr baseline concentrations pre-ICU admission were lacking in most patients, RIFLE categories risk, injury, and failure were defined as SCr.150%, .200%, and .300% of the median of age-specific SCr reference values, respectively (37). Urinary output criteria were not used to assign AKI severity stages.…”

Section: Data Collectionmentioning

confidence: 99%

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CKD and Hypertension during Long-Term Follow-Up in Children and Adolescents Previously Treated with Extracorporeal Membrane Oxygenation

Zwiers¹,

IJsselstijn²,

Rosmalen³

et al. 2014

Clinical Journal of the American Society of Nephrology

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Background and objectives Many children receiving extracorporeal membrane oxygenation develop AKI. If AKI leads to permanent nephron loss, it may increase the risk of developing CKD. The prevalence of CKD and hypertension and its predictive factors during long-term follow-up of children and adolescents previously treated with neonatal extracorporeal membrane oxygenation were determined.Design, setting, participants, & measurements Between November of 2010 and February of 2014, neonatal survivors of extracorporeal membrane oxygenation who visited the prospective follow-up program at 1, 2, 5, 8, 12, and 18 years of age were screened for CKD and hypertension (BP$95th percentile of reference values). CKD was suspected in children with either an eGFR,90 ml/min per 1.73 m 2 or proteinuria (urinary protein-tocreatinine ratio .0.50 for children ages #24 months and .0.20 at .24 months). The RIFLE classification (risk, injury, or failure as 150%, 200%, or 300% of serum creatinine reference values) was used to define AKI during extracorporeal membrane oxygenation without preemptive hemofiltration.Results Median follow-up of 169 screened participants was 8.2 years (interquartile range=5.2-12.1 years). Nine children had a lower eGFR, but all rates were .60 ml/min per 1.73 m 2 . Proteinuria was observed in 20 children (median=0.26 mg protein/mg creatinine; interquartile range=0.23-0.32 mg protein/mg creatinine), and 32 children had hypertension. Only history of AKI was associated with CKD (P=0.004). Children with RIFLE scores injury and failure had 4.3 times higher odds of CKD signs or hypertension than those without AKI (95% confidence interval, 1.6 to 12.1; P=0.004).Conclusions Altogether, 54 participants (32%) had at least one sign of CKD and/or hypertension. However, most values were marginally abnormal, with no immediate consequences for clinical care. Nevertheless, a prevalence of 32% clearly indicates that survivors of neonatal extracorporeal membrane oxygenation, especially those with AKI, are at risk of a more rapid decline of kidney function with increasing age. Therefore, screening for CKD development in adulthood is recommended.

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Section: Discussionmentioning

confidence: 99%

Section: Data Collectionmentioning

confidence: 99%

CKD and Hypertension during Long-Term Follow-Up in Children and Adolescents Previously Treated with Extracorporeal Membrane Oxygenation

Zwiers¹,

IJsselstijn²,

Rosmalen³

et al. 2014

Clinical Journal of the American Society of Nephrology

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“…Pottel et al (12) reported that an increase in serum Cr level on the first days of life. Boer et al (13) showed that a rapid decline of serum Cr during the first weeks of life. Median cord serum Cr concentration was given by Boer et al (12).…”

Section: Discussionmentioning

confidence: 99%

“…Serum Cr concentration rises dramatically in the first 48 hours of life in premature infants with GA 23-35 weeks (16). Sudden cessation of the maternal clearance, low glomerular filtration rate, maternal Cr load on Cr concentration, low tubular clearance of Cr, passive back-diffusion of Cr concentration can increase the serum Cr levels in newborns at the first days of life (11,13). We have shown an increase in serum Cr concentrations at the 1 st day of life, serum Cr concentrations decreased to cord level at the 3 rd day of life, after than a gradually decrease was observed in the neonatal period in term infants.…”

Section: Discussionmentioning

confidence: 99%

Reference Ranges of Serum Blood Urea Nitrogen, Creatinine Concentration and Ultrasonographic Measurement of the Kidneys in Term Healthy Newborns in the Neonatal Period

Kader

Mutlu

Özdoğan

et al. 2017

Gynecol Obstet Reprod Med

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OBJECTIVE: Acute kidney injury is an important problem in neonates. We conducted a cross-sectional prospective study to determine normal serum blood urea nitrogen, creatinine reference ranges and ranges of ultrasonographic measurement of kidneys in healthy term newborns. STUDY DESIGN:Blood samples were collected from total 357 healthy newborns at birth (n=45), 1 st (n=30), 3 rd (n=61), 7 th (n=34), 10 th (n=132), 14 th (n=36), and 28 th (n=19) days of life. Renal ultrasonographic was performed by the same two radiologists on 81 newborns aged 10 days. RESULTS:Serum blood urea nitrogen and creatinine concentrations have reached to the highest level at the first day of life and have returned to cord level at the third day of life. There were gradually decrease in serum blood urea nitrogen and creatinine levels after the first day of life. There were significant difference in both right and left renal length, width, and volumes in terms of gender and these parameters were statistically higher in boys than girls (p<0.05). Birth weight of the boys (3548±539g) was statistically higher than girls (3307±405 g) (p=0.028). There was a positive correlation between birth weight and right (r=0.38, p=0.000) and left kidney volumes (r=0.44, p=0.000). CONCLUSION:Our findings showed that measured blood urea nitrogen and creatinine levels changed in accordance with postnatal days and there was a positive correlation between kidney volume and birth weight of newborns. We concluded that these findings are important for evaluation of acute kidney injury and for screening of for urinary tract anomalies in neonates.

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“…Methods reported in a recent survey of pediatric MRI practices include application of the Schwartz formula to serum creatinine and comparison of serum creatinine with age-appropriate normal ranges [83]. Alternative markers, such as cystatin-C, may provide a more accurate estimate, but reference levels have yet to be defined for neonates [84].…”

Section: Nsf and Gfr Estimation In Childrenmentioning

confidence: 99%

Gadolinium and nephrogenic systemic fibrosis: an update

2013

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Nephrogenic systemic fibrosis (NSF) is a multisystem disease seen exclusively in patients with renal impairment. It can be severely debilitating and sometimes fatal. There is a strong association with gadolinium-based contrast agents used in magnetic resonance imaging (MRI). Risk factors include renal impairment and proinflammatory conditions, e.g. major surgery and vascular events. Although there is no single effective treatment for NSF, the most successful outcomes are seen following restoration of renal function, either following recovery from acute kidney injury or following renal transplantation. There have been ten biopsy-proved pediatric cases of NSF, with no convincing evidence that children have a significantly altered risk compared with the adult population. After implementation of guidelines restricting the use of gadolinium-based contrast agents in at-risk patients, there has been a sharp reduction in new cases and no new reports in children. Continued vigilance is recommended: screening for renal impairment, use of more stable gadolinium chelates, consideration of non-contrast-enhanced MRI or alternative imaging modalities where appropriate.

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Reference values for serum creatinine in children younger than 1 year of age

Cited by 149 publications

References 27 publications

CKD and Hypertension during Long-Term Follow-Up in Children and Adolescents Previously Treated with Extracorporeal Membrane Oxygenation

CKD and Hypertension during Long-Term Follow-Up in Children and Adolescents Previously Treated with Extracorporeal Membrane Oxygenation

Reference Ranges of Serum Blood Urea Nitrogen, Creatinine Concentration and Ultrasonographic Measurement of the Kidneys in Term Healthy Newborns in the Neonatal Period

Gadolinium and nephrogenic systemic fibrosis: an update

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