Reference values for thromboelastometry (ROTEM®) in cynomolgus monkeys (Macaca fascicularis)

Reference intervals for thromboelastometry with the ROTEM® delta in cats

“…The differences in repeatability between different parameters including higher precision for α and MCF was also obvious in other studies (Paltrinieri et al, 2008;Spiezia et al, 2010). The low precision of lysis parameters, which is also in accordance with other reports in different species (Spiezia et al, 2010), should be considered when emphasising these parameters.…”

“…The low precision of lysis parameters, which is also in accordance with other reports in different species (Spiezia et al, 2010), should be considered when emphasising these parameters. Measurements in duplicate may be recommended in such patients.…”

“…Sex is known to have an impact on several ROTEM variables of coagulation in humans (Theusinger et al, 2010). In addition Spiezia et al (2010) found a mild (statistically nonsignificant) tendency towards hypercoagulability in female primates when compared to males when performing non-activated/native ROTEM analyses. However a previous study in dogs using the TEG ® 5000 Hemostasis Analyser was also unable to find an influence of sex (Bauer et al, 2009).…”

“…To the best of our knowledge, results of precision analyses for the instrument ROTEM ® have not been published for cats so far, but within-run precision analyses in cynomolgus monkeys (Spiezia et al, 2010) and horses (Paltrinieri et al, 2008) also show an adequate to high reproducibility of results. Precision analysis results for cats (Marschner et al, 2010) and dogs (Bauer et al, 2009;Wiinberg et al, 2005) are available for the instrument TEG ® 5000 Hemostasis Analyser, where tendentially higher intra-assay CVs were calculated when compared to our study.…”

“…Age has a significant influence on different parameters of haemostasis and fibrinolysis (Attard et al, 2013;Mischke, 1994), and consequently, results of studies in humans revealed a significant influence of age on results of the ROTEM analysis (Oswald et al, 2010;Sucker et al, 2011), whereas, in contrast, no statistically significant correlation between age and ROTEM parameters was found in primates (Spiezia et al, 2010). To the best of the author's knowledge studies on the influence of age on results of thromboelastometry in cats have not been published so far.…”