Reference Values of 14 Serum Trace Elements for Pregnant Chinese Women: A Cross-Sectional Study in the China Nutrition and Health Survey 2010–2012

Liu, Xiaobing; Zhang, Yu; Piao, Jianhua; Mao, Deqian; Li, Yajie; Li, Weidong; Yang, Lichen; Yang, Xiaoguang

doi:10.3390/nu9030309

Cited by 70 publications

(43 citation statements)

References 25 publications

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“…The range of concentrations of some elements in the AF and MS in this study are in agreement with values investigated in earlier literature [ 8 – 11 , 13 , 14 ], although higher or lower levels of some specifications [ 8 , 10 , 11 , 15 – 17 ] were reported. When compared with Nigerian women at the same week of gestation, the results for Cu, Zn and Fe in the serum of Polish women were markedly higher [ 5 ].…”

Section: Discussionsupporting

confidence: 93%

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Evaluation of Essential and Toxic Elements in Amniotic Fluid and Maternal Serum at Birth

Kocyłowski

Grzesiak

Gaj

et al. 2018

Biol Trace Elem Res

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The objective of this study was to determine the concentration and the reference ranges of essential and toxic elements in amniotic fluid (AF) and maternal serum (MS) at birth. This study was conducted among 175 healthy pregnant Caucasian European women aged 18-42. AF and maternal blood samples were collected during delivery. An inductively coupled plasma mass spectrometry (ICP-MS) technique was used to determine the levels of Mg, Co, Cu, Zn, Sr, Cd, Ba, Pb, U, Ca, Cr, Al, Mn, V, Fe, As, Se and Sb in AF and MS. The range of reference values was calculated for all analyzed elements in the serum and AF. The mean concentrations of elements, except Pb, were generally higher in MS than in AF. Multiple regression analysis showed that the maternal/newborn body mass (MBM/NBM) ratio was a strong negative predictor (among maternal age and gravidity) of Mg concentration in amniotic fluid. In the serum, MBN/NBM ratio was a strong positive predictor of Cu concentration. Moreover, regression analysis showed that maternal age was an independent positive predictor of the Se level in maternal serum. The reference value ranges of 18 essential and toxic elements were established in AF and MS among a population of healthy pregnant Polish women at delivery. The level of Mg, Co, Cu, Ca and Se in AF and MS can be determined by maternal age and MBM/NBM ratio. These results can be useful in counseling individuals with pregnancies affected by exposure to one of the parameters under investigation.

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Section: Discussionsupporting

confidence: 93%

“…Furthermore, pregnancy increases the maternal need for enzymes containing Cu and this leads to an increase in Cu absorption. Another potential reason may be decreased biliary Cu excretion induced by hormonal changes in pregnancy [ 8 , 21 ].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Essential and Toxic Elements in Amniotic Fluid and Maternal Serum at Birth

Kocyłowski

Grzesiak

Gaj

et al. 2018

Biol Trace Elem Res

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“…In South Africa, pregnant women attending free or private prenatal care are prescribed these supplements; this was also the case with the population of this study. The mean value of 466.3 µg/L for Zn in our study is much lower than the mean values found in pregnant woman in Spain and China (758 µg/L; 710 µg/L), respectively [57,58]. In addition, two recent studies in China reported mean Zn concentrations of 5106 and 5434 µg/L; these levels are more than 10 times higher than the Zn levels found in our study [59,60].…”

Section: Discussioncontrasting

confidence: 85%

“…Levels of Se were found to be very similar to those reported in other studies, 56 µg/L viz. 65 µg/L (Bermudez et al, 2015 andLiu et al, 2017), indicating sufficient intake of this element by our study population [57,58]. Maternal serum Al levels were positively associated with Cu, Zn, Se in serum; Cu, Se and Zn are important nutrients whose requirements increase with pregnancy.…”

Section: Discussionmentioning

confidence: 69%

In Utero Exposure to Aluminium and Other Neurotoxic Elements in Urban Coastal South African Women at Delivery: An Emerging Concern

Röllin

Channa

Olutola

et al. 2020

IJERPH

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Aluminium (Al) is a non-essential neurotoxicant and there is limited information regarding exposure to Al in utero. This study sought to evaluate the in utero exposure to Al in urban South African women, its effects on birth outcomes and possible synergistic effects between Al, essential and neurotoxic elements such as lead (Pb), mercury (Hg) and arsenic (As), as well as a a potential sex-dependent response to these elements in neonates. This study has found elevated levels of Al in urban women at delivery. The Spearman’s rank correlation coefficients (p-value) of the association between maternal serum Al and birth outcomes (gestational age and parity), and between maternal serum Al and Cu, Zn and Se, were statistically significant. However, in the general and the stratified models, no association was found between any of the birth outcomes and maternal serum Al. The association between maternal serum Al and neurotoxic elements at delivery showed a significant positive correlation for Pb only (rho = 0.361; p < 0.001) which was found to be sex-dependent in neonates (males, rho = 0.285; p < 0.004 and females, rho = 0.444, p < 0.001). Our preliminary findings indicate that in utero exposure to Al is an emerging concern requiring further research and directives from public health authorities.

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“…The results showed that serum Fe, Zn, and Se concentrations were significantly reduced, but this study has not examined the association between this decline and the incidence of diabetes. 29 The cut-off points for gestational diabetes were obtained 48.2 µg/L with a sensitivity of 83.3% and specificity of 94%. In previous studies, only the Se value was compared in the case and control groups and the cutoff point was not reported.…”

Section: Discussionmentioning

confidence: 99%

<p>The Predictive Value of Selenium in Diagnosis of Gestational Diabetes: A Nested Case-Control Study</p>

Moshfeghy¹,

Bashiri²,

Dabbaghmanesh³

et al. 2020

IJGM

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The present study was conducted to determine the predictive value of Selenium (Se) in the diagnosis of Geatational diabetes Mellitus (GDM). Methods: This is a nested case-control study with 636 normal pregnant mothers in their 11th-13th weeks. Gestational diabetes screening was done in weeks 24-28. Twenty-five individuals were detected as GDM, and for every GDM two gestational age-matched normal pregnant women were selected. The blood selenium level was measured in both groups. Results: The serum Se level in the case group was lower than that of the control group (50.60 ± 10.88 versus 66.02 ± 10.57) in the first trimester. Also, in the second trimester, Se was lower in the case group (39.87 ± 10.23 versus 63.17 ± 10.22). The best cutoff point for selenium in order to predict the incidence of gestational diabetes in our study was 48.2. Pregnant women with selenium levels below 48.2 were more likely to develop gestational diabetes. Conclusion: Serum selenium was lower in the GDM subjects compared with age-matched control group; the clinical concept and mechanism of this finding need to be investigated through further studies.

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Reference Values of 14 Serum Trace Elements for Pregnant Chinese Women: A Cross-Sectional Study in the China Nutrition and Health Survey 2010–2012

Cited by 70 publications

References 25 publications

Evaluation of Essential and Toxic Elements in Amniotic Fluid and Maternal Serum at Birth

Evaluation of Essential and Toxic Elements in Amniotic Fluid and Maternal Serum at Birth

In Utero Exposure to Aluminium and Other Neurotoxic Elements in Urban Coastal South African Women at Delivery: An Emerging Concern

<p>The Predictive Value of Selenium in Diagnosis of Gestational Diabetes: A Nested Case-Control Study</p>

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