Reference values of aortic pulse wave velocity in a large healthy population aged between 3 and 18 years

Hidvégi, Erzsébet Valéria; Illyés, Miklós; Benczúr, Béla; Bocskei, R.; Rátgéber, László; Lenkey, Zsófia; Molnár, Ferenc; Cziráki, Attila

doi:10.1097/hjh.0b013e328359562c

Cited by 88 publications

(77 citation statements)

References 34 publications

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“…An association between PWV and age was previously demonstrated in a large group of children. 24 Despite the positive correlation between PWV and BMI observed in our sample (Table 4), the latter did not prove to be a significant predictor of PWV on regression analysis. Other authors have documented associations between PWV and other markers of cardiovascular risk such as preperitoneal fat tissue thickness and waist/hip circumference.…”

Section: Discussioncontrasting

confidence: 60%

Central aortic pressure, arterial stiffness and echocardiographic parameters of children with overweight/obesity and arterial hypertension

Wójtowicz¹,

Łempicka²,

Łuczyński³

et al. 2017

Adv Clin Exp Med

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Section: Discussioncontrasting

confidence: 60%

Central aortic pressure, arterial stiffness and echocardiographic parameters of children with overweight/obesity and arterial hypertension

Wójtowicz¹,

Łempicka²,

Łuczyński³

et al. 2017

Adv Clin Exp Med

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“…In the general adult population, PWV increases with increasing age and blood pressure levels. 41 However, in children, the influence of age on PWV is less clear [42][43][44] and may be confounded by pubertal status. One study in a healthy population of children between the ages of 3 to 18 years, reported that PWV remained unchanged during childhood but started to increase in girls at 10.4 years and in boys at 12.1 year, 42 suggesting an influence of pubertal status rather than age.…”

Section: Discussionmentioning

confidence: 99%

“…41 However, in children, the influence of age on PWV is less clear [42][43][44] and may be confounded by pubertal status. One study in a healthy population of children between the ages of 3 to 18 years, reported that PWV remained unchanged during childhood but started to increase in girls at 10.4 years and in boys at 12.1 year, 42 suggesting an influence of pubertal status rather than age. 45 Sex and pubertal status, through changes in vasoactive hormone concentrations, are critical factors known to influence arterial wall properties and function.…”

Section: Discussionmentioning

confidence: 99%

Obesity and Arterial Stiffness in Children

Coté

Phillips

Harris

et al. 2015

ATVB

132

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Objective-Childhood obesity is associated with risk factors for cardiovascular disease. Arterial stiffness is considered one of the earliest detectable measures of vascular damage. There is controversy in the literature regarding the effects of childhood obesity on arterial stiffness. The objective of this study is to systematically review the literature and to conduct a meta-analysis comparing measures of central arterial stiffness in children and adolescents with obesity to healthy body mass index controls. Approach and Results-Literature searches were conducted using databases (eg, MEDLINE, EMBASE) and citations cross-referenced. Studies assessing central pulse wave velocity or β-stiffness index were included. A random effects meta-analysis of the standardized mean difference and 95% confidence intervals in arterial stiffness between children with obesity and control children was performed for each arterial stiffness measure. A total of 523 studies were identified. Fifteen case-control studies were included, with 2237 children/adolescents (1281 with obesity, 956 healthy body mass index controls) between 5 and 24 years of age. All studies measuring carotid and aortic β-stiffness index and 10/12 studies measuring central pulse wave velocity reported greater arterial stiffness in children/adolescents with obesity compared with controls. A random effects meta-analysis was performed revealing a significant effect of obesity on pulse wave velocity (standardized mean difference=0.718; 95% confidence interval=0.291-1.415), carotid β-stiffness index (0.862; 0.323-1.402), and aortic β stiffness index (1.017; 0.419-1.615). Conclusion-These findings indicate that child/adolescent obesity is associated with greater arterial stiffness. However, further research is needed to address confounders, such as pubertal status, that may affect this relationship in children. In the future, these techniques may be useful in risk stratification and guiding clinical management of obese children to optimize cardiovascular outcomes.

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“…In adults, the ‘gold standard' for the noninvasive assessment of arterial stiffness is carotid-femoral PWV (cfPWV) [5]. While other methods of assessing aortic PWV have been validated, and largely show comparable results [7,8,9], in this paper, we will primarily focus on cfPWV as measured by applanation tonometry, unless otherwise specified.…”

Section: How To Measure Arterial Stiffness?mentioning

confidence: 99%

Arterial Stiffness in Children: Pediatric Measurement and Considerations

Savant

Furth

Meyers

2014

Pulse

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Background: Arterial stiffness is a natural consequence of aging, accelerated in certain chronic conditions, and predictive of cardiovascular events in adults. Emerging research suggests the importance of arterial stiffness in pediatric populations. Methods: There are different indices of arterial stiffness. The present manuscript focuses on carotid-femoral pulse wave velocity and pulse wave analysis, although other methodologies are discussed. Also reviewed are specific measurement considerations for pediatric populations and the literature describing arterial stiffness in children with certain chronic conditions (primary hypertension, obesity, diabetes, chronic kidney disease, hypercholesterolemia, genetic syndromes involving vasculopathy, and solid organ transplant recipients). Conclusions: The measurement of arterial stiffness in children is feasible and, under controlled conditions, can give accurate information about the underlying state of the arteries. This potentially adds valuable information about the functionality of the cardiovascular system in children with a variety of chronic diseases well beyond that of the brachial artery blood pressure.

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Reference values of aortic pulse wave velocity in a large healthy population aged between 3 and 18 years

Abstract: Objective. The measurement of aortic pulse wave velocity (PWV ao

Cited by 88 publications

References 34 publications

Central aortic pressure, arterial stiffness and echocardiographic parameters of children with overweight/obesity and arterial hypertension

Central aortic pressure, arterial stiffness and echocardiographic parameters of children with overweight/obesity and arterial hypertension

Obesity and Arterial Stiffness in Children

Arterial Stiffness in Children: Pediatric Measurement and Considerations

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