Reference values of cardiac volumes, dimensions, and new functional parameters by MR: A multicenter, multivendor study

Aquaro, Giovanni Donato; Camastra, Giovanni; Monti, Lorenzo; Lombardi, Massimo; Pepe, Alessia; Castelletti, Silvia; Maestrini, Viviana; Todiere, Giancarlo; Masci, Pier Giorgio; Giovine, Gabriella Di; Barison, Andrea; Dellegrottaglie, Santo; Marra, Martina Perazzolo; Pontone, Gianluca; Bella, Gianluca Di

doi:10.1002/jmri.25450

Cited by 98 publications

(98 citation statements)

References 17 publications

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“…Biventricular volumes, ejection fraction and mass, as well as atrial volumes were measured by manually tracing the endocardial and epicardial border at end‐ventricular diastole and systole using cine short‐axis images. Previously reported reference values of normality for LV and RV volumes were used …”

Section: Methodsmentioning

confidence: 99%

“…A comprehensive MR evaluation was performed following an examination protocol for each CHD as previously published. 13 In particular, biventricular function was assessed by breath-hold, steadystate, free-precession cine imaging in cardiac short-axis, encompassing both ventricles and atria by contiguous 8-mm thick slices (field of view 32-38 cm, repetition time (TR) / echo time (TE) = 2, flip angle 45 , matrix 224 × 224, reconstruction matrix 256 × 256, 30 cardiac phases, views per segment [14][15][16][17][18][19][20][21][22][23][24]. Pulmonary and aortic flow was evaluated using a free-breathing velocity-encoded phase-contrast gradient-echo cine sequence with the following parameters: TR/TE 12/5 msec, flip angle 20 , field of view 30, phase field of view 1, matrix 192 × 192, reconstruction matrix 256 × 256, slice thickness 5 mm, encoding velocity 150-400 cm/s.…”

Section: Magnetic Resonance Protocolmentioning

confidence: 99%

“…Previously reported reference values of normality for LV and RV volumes were used. 14 Pulmonary artery flow and aortic flow were measured by the analysis of velocity-encoded phase contrast images as previously described. 15…”

Section: Magnetic Resonance Protocolmentioning

confidence: 99%

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Cardiac Magnetic Resonance Evaluation of Pulmonary Transit Time and Blood Volume in Adult Congenital Heart disease

Ait-Alì

Aquaro

Peritore³

et al. 2019

Magnetic Resonance Imaging

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Background Management of adults with repaired congenital heart disease (CHD) is still challenging. Heart failure secondary to residual anatomical sequels or arrhythmic events is not rare in this population. MRI has emerged as an accurate tool to quantify pulmonary transit time (PTT) of intravenous contrast agents and pulmonary blood volume (PBV). Purpose To determine the relationship between PTT, and conventional indexes of ventricular dysfunction and heart failure in a cohort of adults with CHD and to assess its association with adverse outcomes. Study Type Retrospective. Subjects 89 adult CHD patients (56 males, age 34 ± 11 years) and 14 age‐ and sex‐matched healthy subjects. Field Strength/Sequence First‐pass perfusion and standard sequences for ventricular volumes and function and flow analysis at 1.5T. Assessment PTT was calculated as the time required for a bolus of contrast agent to pass from the right ventricle to the left atrium, expressed both in seconds (PTTS) and number of heartbeats (PTTB). The pulmonary blood volume index (PBVI) was measured by the product of PTTB and the pulmonary artery stroke volumes. Statistical Tests Student's independent t‐test analysis of variance (ANOVA) and Mann–Whitney nonparametric; Pearson's or Spearman's correlation; Kaplan–Meier method. Results PTTS and PTTB were significantly higher in patients than in controls (7.6 ± 3 vs. 5.6 ± 1.2 sec, P = 0.01 and 8 ± 3 vs. 6 ± 1 bpm, P = 0.01, respectively). PTTS showed negative correlation with left ventricle ejection fraction (LVEF) and cardiac index (CI) (r = –0.3, P = 0.004, and r = –0.4, P < 0.001, respectively) as well as with left ventricle and atrial volumes. By Kaplan–Meier survival analysis, PTTB >8 bpm was associated with significant increased risk of adverse outcome at mid‐term follow‐up. Moreover, patients with both increased PTTB and PBV have higher amino‐terminal portion of the prohormone brain natriuretic peptide (NT‐proBNP) and lower LVEF. Data Conclusion PTT is prolonged in adult CHD in comparison with healthy subjects, likely reflecting reduced CI and ventricular dysfunction. Level of Evidence: 3 Technical Efficacy: Stage 3 J. Magn. Reson. Imaging 2019;50:779–786.

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Section: Methodsmentioning

confidence: 99%

Section: Magnetic Resonance Protocolmentioning

confidence: 99%

See 1 more Smart Citation

Cardiac Magnetic Resonance Evaluation of Pulmonary Transit Time and Blood Volume in Adult Congenital Heart disease

Ait-Alì

Aquaro

Peritore³

et al. 2019

Magnetic Resonance Imaging

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“…Left ventricular volumes, mass, and EF were measured using a previously validated software (EasyVision, version 4.0; Philips Medical Systems) and categorized in accordance with reference values …”

Section: Methodsmentioning

confidence: 99%

Left ventricular endocardial longitudinal dysfunction persists after acute myocarditis with preserved ejection fraction

et al. 2018

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Background The aim of present study was to assess left ventricular (LV) myocardial deformation and changes over time in patients with acute myocarditis (AM) with preserved ejection fraction detected by late gadolinium enhancement (LGE) magnetic resonance imaging. Methods Thirty‐five male patients with AM diagnoses and preserved systolic function based on cardiac magnetic resonance imaging (MRI) were prospectively enrolled. On admission, echocardiography with measurements of global and segmental longitudinal (LS) strains was performed both at the endocardial (ENDO) and epicardial (EPI) levels. Findings were compared to 25 control subjects. Twenty‐six patients were also monitored over a 22‐month follow‐up (FU group). Results On admission, global ENDO‐LS was poorer in magnitude in AM (−19.2 ± 3.1) than in controls (−24.0 ± 1.05) (P < 0.0001), whereas EPI‐LS was not different (−20.6 ± 3.4 vs −19.7 ± 6 P = NS). A functional increase in magnitude in both ENDO‐LS (−20.8 ± 5.4, P = NS) and EPI‐LS (−22.6 ± 4.6, P = 0.02) was found in FU vs AM patients. Conclusions The present study demonstrates a steady ENDO‐LS impairment in infarct‐like AM during a 2‐year follow‐up period, despite a preserved LV ejection fraction.

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“…Reference values of cardiac MRI dimensions have been proposed. 22 The authors defined LVH according to cardiac MRI measurements based on previously reported and accepted parameters ([ 74 g/m 2 in males and [ 63 g/m 2 in females). 23 Prior research using conventional Anger SPECT cameras demonstrated that LV mass can also be computed from radionuclide MPI studies.…”

mentioning

confidence: 99%

Assessment of left ventricular mass by SPECT MPI

Packard

Maddahi

2019

Journal of Nuclear Cardiology

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A. Gimelli, R. Liga et al. report on left ventricular (LV) mass determination using two commercially available softwares that they applied to cadmium-zinc-telluride (CZT) single-photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI), and compared results to cardiac magnetic resonance imaging (MRI) which was the reference standard. 1 For their study, they retrospectively identified n = 25 patients who underwent MPI with gated 99m Tc-tetrofosmin acquired on a CZT camera and had a cardiac MRI within 12 ± 3 weeks. To put the authors' work on LV mass determination in perspective, we will address the importance, accepted methods, and nuclear imaging approaches to LV mass measurement.A common cardiac adaptive mechanism in the setting of hemodynamic overload is the compensatory increase in LV mass, as explained by the Law of LaPlace in whichwhere s is the ventricular wall stress, P is the ventricular pressure, r is the ventricular radius, and T is the ventricular wall thickness. 2 However, this compensatory increase in ventricular wall thickness is detrimental on the long run, as demonstrated by multiple clinical studies. Indeed, an increase in LV wall thickness or mass, typically due to left ventricular hypertrophy (LVH), predicts an increased risk of cardiovascular morbidity and mortality as determined in the Framingham Heart Study, even after adjustment for major risk factors. 3 Moreover, the severity of LVH is an independent predictor of death and coronary revascularization. 4 These early observations have been confirmed by more contemporary data where LV mass and LVH were found to be predictive of the need for future revascularization, 5 and of the occurrence of myocardial infarction and cardiac death 6 in patients with or without stress-inducible ischemia 7 or in the setting of asymptomatic aortic stenosis. 8 In patients with a previous myocardial infarction, prognosis is related to the percentage of viable LV mass, and LV mass measurement can assess the development of compensatory focal LVH. 9 Quantification of LV mass is also useful in the evaluation and management of patients with valvular heart disease and hypertrophic cardiomyopathy. Further, LV mass has been demonstrated to predict the incidence of congestive heart failure in the Multi-Ethnic Study of Atherosclerosis. 10 In addition, assessment of LV mass can be used to monitor response to therapies such as weight reduction 11 or kidney transplantation. 12

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Reference values of cardiac volumes, dimensions, and new functional parameters by MR: A multicenter, multivendor study

Abstract: 2 J. Magn. Reson. Imaging 2017;45:1055-1067.

Cited by 98 publications

References 17 publications

Cardiac Magnetic Resonance Evaluation of Pulmonary Transit Time and Blood Volume in Adult Congenital Heart disease

Cardiac Magnetic Resonance Evaluation of Pulmonary Transit Time and Blood Volume in Adult Congenital Heart disease

Left ventricular endocardial longitudinal dysfunction persists after acute myocarditis with preserved ejection fraction

Assessment of left ventricular mass by SPECT MPI

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