Referral to an Extracorporeal Membrane Oxygenation Center and Mortality Among Patients With Severe 2009 Influenza A(H1N1)

Noah, Moronke A.; Peek, Giles J.; Finney, Simon J.; Griffiths, Mark; Harrison, David A; Grieve, Richard; Sadique, Zia; Sekhon, Jasjeet S.; McAuley, Daniel F.; Firmin, Richard K.; Harvey, Christopher J.; Cordingley, Jeremy; Price, Susanna; Vuylsteke, Alain; Jenkins, David P.; Noble, David W.; Bloomfield, Roxanna; Walsh, Timothy; Perkins, Gavin D.; Menon, David; Taylor, Bruce L.; Rowan, Kathy

doi:10.1001/jama.2011.1471

Cited by 769 publications

(606 citation statements)

References 45 publications

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“…Several reports describe cases of influenza A (H1N1)-associated acute respiratory distress syndrome requiring extracorporeal membrane oxygenation (ECMO) for severe hypoxemia refractory to conventional treatment [1][2][3][4][5][6]. However, uncertainty regarding the appropriate indication for ECMO in these patients still remains [7][8][9][10].…”

Section: Introductionmentioning

confidence: 99%

ECMO criteria for influenza A (H1N1)-associated ARDS: role of transpulmonary pressure

et al. 2012

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This is an author version of the contribution published on:Questa è la versione dell'autore dell'opera: [Intensive Care Medicine,38(3),2012, doi: 10.1007/s00134-012-2490 The definitive version is available at: La versione definitiva è disponibile alla URL: [http://download.springer.com/static/pdf/687/art%253A10.1007%252Fs00 134-012-2490 Conclusions:Abnormalities of chest wall mechanics may be present in some patients with influenza A (H1N1)-associated ARDS. These abnormalities may not be inferred from measurements of end-inspiratory plateau pressure of the respiratory system 1 (PPLAT RS ). In these patients, titrating PEEP on PPLAT RS may overestimate the incidence of hypoxemia refractory to conventional ventilation leading to un-appropriate use of ECMO.

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Section: Introductionmentioning

confidence: 99%

ECMO criteria for influenza A (H1N1)-associated ARDS: role of transpulmonary pressure

et al. 2012

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“…2 The United Kingdom ECMO cohort study showed an approximate 50% reduction in mortality in those referred for ECMO during the same pandemic. 3 These studies are in contrast to the conclusion of the France REVA-SRLF H1N1 Registry. 4 In that study, 103 patients received ECMO, and 52 patients in the cohort were propensity matched to non-ECMO patients.…”

mentioning

confidence: 89%

“…2 Dans une autre étude de cohorte d'ECMO réalisée au Royaume-Uni, on a observé une réduction d'environ 50 % de la mortalité chez les patients référés pour un traitement à l'ECMO pendant la même épidémie. 3 Ces études vont à l'encontre de la conclusion du registre français REVA-SRLF H1N1. 4 Dans cette dernière étude, 103 patients ont reçu un traitement à l'ECMO, et 52 patients de la cohorte ont été appariés selon les scores de propension à des patients ne recevant pas d'ECMO.…”

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Extracorporeal membrane oxygenation for blastomycosis-related severe ARDS: a new indication as a rescue therapy?

Steinberg

Goldenberg

Laffey

2015

Can J Anesth/J Can Anesth

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“…The conventional ventilation versus ECMO for severe adult respiratory failure (CESAR) trial first reported a significant improvement in 6 months disability‐free survival in the ECMO group, when compared to conventional ventilation patients 5. Since then, several studies have shown the effectiveness of ECMO for influenza A (H1N1)‐related severe acute respiratory failure in 2009–2010 6, 7. Following the pandemic of influenza A (H1N1), however, few reports have explored the benefits of ECMO 8.…”

Section: Introductionmentioning

confidence: 99%

Respiratory extracorporeal membrane oxygenation for severe sepsis and septic shock in adults: a propensity score analysis in a multicenter retrospective observational study

Takauji

Hayakawa

Ono

et al. 2017

Acute Medicine & Surgery

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AimThis multicenter retrospective observational study aimed to evaluate the efficacy of extracorporeal membrane oxygenation (ECMO) support for septic patients with severe respiratory failure using propensity score analyses.MethodsThe data of severe sepsis patients from 42 intensive care units between January 2011 and December 2013 were retrospectively collected. Propensity score matching analyses were undertaken for severe respiratory failure patients with/without veno‐venous ECMO support. The main outcome was in‐hospital all‐cause mortality.ResultsOf 3195 patients with severe sepsis, 570 had severe respiratory failure. Forty patients in the ECMO group were matched with 150 patients in the control group. A survival time analysis revealed no difference in the in‐hospital survival (hazard ratio, 0.854; 95% confidence interval, 0.531–1.373; P = 0.515). Two‐hundred and eighty‐five patients had severe respiratory failure induced by lung infection. Twenty‐five ECMO group patients were matched with 89 patients in the control group. In the ECMO group, the survival time was longer than in the control group (hazard ratio, 0.498; 95% confidence interval, 0.279–0.889; P = 0.018). The number of renal replacement therapy‐ and vasopressor‐free days improved. The ECMO group received more red blood cells transfused than the control group, but there was no significant difference in the rate of severe bleeding complications between the groups.ConclusionsThere was no difference in the in‐hospital survival between the ECMO group and control group among overall septic patients with severe respiratory failure. However, in sepsis patients with severe respiratory failure induced by lung infection, ECMO support may improve their survival time.

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Referral to an Extracorporeal Membrane Oxygenation Center and Mortality Among Patients With Severe 2009 Influenza A(H1N1)

Abstract: For patients with H1N1-related ARDS, referral and transfer to an ECMO center was associated with lower hospital mortality compared with matched non-ECMO-referred patients.

Cited by 769 publications

References 45 publications

ECMO criteria for influenza A (H1N1)-associated ARDS: role of transpulmonary pressure

ECMO criteria for influenza A (H1N1)-associated ARDS: role of transpulmonary pressure

Extracorporeal membrane oxygenation for blastomycosis-related severe ARDS: a new indication as a rescue therapy?

Respiratory extracorporeal membrane oxygenation for severe sepsis and septic shock in adults: a propensity score analysis in a multicenter retrospective observational study

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