Nearly half of the world's population consumes alcohol, with approximately 20% engaging in binge drinking and 5%-10% drinking excessively over the long term (Manthey et al., 2019). Alcohol consumption is a leading cause of liver disease and mortality in both the United States and Europe, contributing to a significant public health burden (Karlsen et al., 2022). The risk of developing alcoholassociated liver disease (ALD) varies widely among individuals, influenced by factors such as genetics (Schwantes-An et al., 2024; Yuan How to cite this article: Zuluaga, P. & Liangpunsakul, S. (2024) From detection to intervention, optimizing care for patients with alcohol use disorder and advanced hepatic fibrosis.