Direct numerical and large eddy simulations are powerful tools for analyses of turbulent flows at low, respectively large Reynolds or Rayleigh numbers in fundamental research. The current status of both methods and recent extensions are compiled. The progress achieved with subgrid scale models and numerics makes the method attractive for applications to nuclear research and engineering. Examples of realistic technical flows are discussed. Open problems are mainly related to more general subgrid scale models for large complex containers, to the wall and inlet conditions for high Reynolds number and buoyant flows, and to discretisation schemes for local refinement of spatial resolution. As a classical example for the use of direct simulations, results are presented for a turbulent internally heated horizontal fluid layer. The analysis of the closure terms in the transport equation of the kinetic energy demonstrates major difficulties of the conventional statistical modelling for partially stably stratified convection.