Refining the role of carpal tunnel syndrome in cardiac amyloidosis

Early diagnosis and management of cardiac amyloidosis: A clinical perspective

“…As a case in point, knowledge that a patient suffered from carpal tunnel syndrome may appear superfluous, but instead could hint at the presence of ATTR-CA in a compatible clinical scenario. [24][25][26][27][28][29] Conversely, the concurrent presence of progressive peripheral neuropathy starting from the lower limbs and autonomic neuropathy with symptoms such as postural hypotension, erectile dysfunction or altered bowel motility could corroborate the diagnosis of AL or ATTR-v amyloidosis. The combination of peripheral neuropathy affecting small unmyelinated fibres and autonomic neuropathy, excluding severe diabetic neuropathy, is indeed rare.…”

“…Additionally, a comprehensive history‐taking which is a fundamental part of internist's daily routine, can prompt diagnosis by revealing useful details. As a case in point, knowledge that a patient suffered from carpal tunnel syndrome may appear superfluous, but instead could hint at the presence of ATTR‐CA in a compatible clinical scenario 24–29 . Conversely, the concurrent presence of progressive peripheral neuropathy starting from the lower limbs and autonomic neuropathy with symptoms such as postural hypotension, erectile dysfunction or altered bowel motility could corroborate the diagnosis of AL or ATTR‐v amyloidosis.…”