2021
DOI: 10.5826/dpc.1103a68
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Reflectance Confocal Microscopy of Aging Skin and Skin Cancer

Abstract: Skin aging is a complex process that causes morphologic variations. Some of these variations havebeen hypothesized to be involved in skin cancer development. This paper reviews current knowledgeof the features of aged skin as seen with reflectance confocal microscopy (RCM). Basic principles ofthe technique are described, and the RCM features of healthy skin and skin cancer are briefly discussed.Moreover, the RCM features at different layers of young and elderly skin are described, as arethe variations that occ… Show more

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Cited by 32 publications
(33 citation statements)
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“…RCM can be used to observe the epidermal layers, the dermal–epidermal junction (DEJ), and the upper layers of the dermis, 7 thus allowing for the computation of several quantitative descriptors of skin structure, such as keratinocyte density, number of basal keratinocytes around each dermal papilla, length of DEJ, and circumference of dermal papillae. Measuring such parameters on RCM images enables the quantitative study of skin structures and their evolution over time, for example, as a response to different stimuli.…”
Section: Rcm Imaging In Skin Researchmentioning
confidence: 99%
See 2 more Smart Citations
“…RCM can be used to observe the epidermal layers, the dermal–epidermal junction (DEJ), and the upper layers of the dermis, 7 thus allowing for the computation of several quantitative descriptors of skin structure, such as keratinocyte density, number of basal keratinocytes around each dermal papilla, length of DEJ, and circumference of dermal papillae. Measuring such parameters on RCM images enables the quantitative study of skin structures and their evolution over time, for example, as a response to different stimuli.…”
Section: Rcm Imaging In Skin Researchmentioning
confidence: 99%
“…2(c) ] are the second and third layers in the epidermis from the skin surface, respectively. They are composed of keratinocytes arranged in a honeycomb pattern in minimally pigmented skin and a cobblestone pattern in heavily pigmented skin 7 [ Figs. 3(b) and 3(c) ].…”
Section: Rcm Imaging In Skin Researchmentioning
confidence: 99%
See 1 more Smart Citation
“…It will enable non‐dermatologists and dermatologists to make decisions faster and with more confidence as the decisions will be made from a larger sample size of the randomized images. Some fundamental studies have been done to show use of RCM and MPM to understand age‐related changes in skin (including collagen organization) in young versus old or photo‐aged subjects 21,22 . However, there is limited effort in expanding the power of these imaging techniques to capture improvement in treatment, which requires sophisticated image processing to obtain quantitative information 3,13,16 …”
Section: Introductionmentioning
confidence: 99%
“…Some fundamental studies have been done to show use of RCM and MPM to understand age-related changes in skin (including collagen organization) in young versus old or photo-aged subjects. 21,22 However, there is limited effort in expanding the power of these imaging techniques to capture improvement in treatment, which requires sophisticated image processing to obtain quantitative information. 3,13,16 The aim of this study was to develop and demonstrate a holistic imaging and image processing approach to visualize and quantify improvements in dermal remodeling (primarily collagen).…”
Section: Introductionmentioning
confidence: 99%