Reflection impulsivity in adolescent cannabis users: a comparison with alcohol-using and non-substance-using adolescents

Solowij, Nadia; Jones, Katy A.; Rozman, Megan; Davis, Sasha; Ciarrochi, Joseph; Heaven, Patrick C. L.; Pesa, Nicole; Lubman, Dan I.; Yücel, Murat

doi:10.1007/s00213-011-2486-y

Cited by 104 publications

(95 citation statements)

References 78 publications

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“…There is considerable evidence implicating the use of various cannabis derivatives in altered cognition and decision making, including risk taking behavior, irrational (or excessive) gambling, as well as impulsive and apathetic patterns of choice. This evidence comes mainly from human studies (Dougherty et al 2013;Grant et al 2012;Hermann et al 2009;Lane et al 2005;Moreno et al 2012;Solowij et al 2012;Whitlow et al 2004) and related work in animals (Boomhower et al 2013;Egerton et al 2006;Egerton et al 2005;Mishima et al 2002) that largely concurs with the results of the human studies. The role of cannabinoid signaling in decision-making pathways and the involvement of cannabinoid receptors in frontal cortical circuits of decision making have not received much attention to date.…”

Section: Introductionsupporting

confidence: 66%

Activation of cannabinoid system in anterior cingulate cortex and orbitofrontal cortex modulates cost-benefit decision making

et al. 2014

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Despite the evidence for altered decision making in cannabis abusers, the role of the cannabinoid system in decision-making circuits has not been studied. Here, we examined the effects of cannabinoid modulation during costbenefit decision making in the anterior cingulate cortex (ACC) and orbitofrontal cortex (OFC), key brain areas involved in decision making. We trained different groups of rats in a delay-based and an effort-based form of cost-benefit T-maze decision-making task. During test days, the rats received local injections of either vehicle or ACEA, a cannabinoid type-1 receptor (CB1R) agonist in the ACC or OFC. We measured spontaneous locomotor activity following the same treatments and characterized CB1Rs localization on different neuronal populations within these regions using immunohistochemistry. We showed that CB1R activation in the ACC impaired decision making such that rats were less willing to invest physical effort to gain high reward. Similarly, CB1R activation in the OFC induced impulsive pattern of choice such that rats preferred small immediate rewards to large delayed rewards. Control tasks ensured that the effects were specific for differential cost-benefit tasks. Furthermore, we characterized widespread colocalizations of CB1Rs on GABAergic axonal ends but few colocalizations on glutamatergic, dopaminergic, and serotonergic neuronal ends. These results provide first direct evidence that the cannabinoid system plays a critical role in regulating cost-benefit decision making in the ACC and OFC and implicate cannabinoid modulation of synaptic ends of predominantly interneurons and to a lesser degree other neuronal populations in these two frontal regions.

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Section: Introductionsupporting

confidence: 66%

Activation of cannabinoid system in anterior cingulate cortex and orbitofrontal cortex modulates cost-benefit decision making

et al. 2014

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“…Normative data was not available for the information sampling task; however, the amount of information sampled (boxes opened) was comparable to previous studies of healthy young adults with both the cost and no-cost conditions of the task (Irvine et al, 2013;Solowij et al, 2012).…”

Section: Discussionsupporting

confidence: 66%

“…In young people, neurocognitive deficits in sustained attention and executive function including spatial working memory have been observed in depressive disorders (Castaneda et al, 2008;Han et al, 2012;Maalouf et al, 2011), substance abuse issues (Solowij et al, 2012;Tapert and Brown, 1999) and those at risk of psychosis (Myles-Worsley et al, 2007). There is a paucity of evidence investigating the impact of these neurocognitive deficits on employment and educational engagement, and to our knowledge there are no studies assessing neurocognitive impairments in mild or subthreshold disorders in a youth help-seeking population.…”

Section: Introductionmentioning

confidence: 99%

Prediction of vocational participation and global role functioning in help-seeking young adults, from neurocognitive, demographic and clinical variables

Cairns

Kavanagh

Dark

et al. 2017

Journal of Affective Disorders

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This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting galley proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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“…El componente de toma de decisiones consiste en la capacidad de elegir una opción ventajosa ante un problema que implica informar acerca de la elección, considerar los tipos de errores cometidos y los riesgos que implica la elección. Del número total de estudios encontrados, 30,76 % evaluaron este aspecto (36)(37)(38)(39). El 75 % de los artículos encontraron que el consumo de alcohol, ya sea alguna vez en los últimos seis meses o el consumo binge (consumo intensivo de alcohol) probablemente afectó la toma de decisiones.…”

Section: Resultsunclassified

Alcohol Consumption and Executive Functions in Adolescents: A Systematic Review

Villegas-Pantoja¹,

Castillo²,

Benavides-Torres³

et al. 2013

Aquichan

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Objetivo: el consumo de alcohol entre los estudiantes universitarios se ha convertido en una preocupación creciente en los últimosaños, por lo que este estudio fue desarrollado con el objetivo de identificar el consumo de esta sustancia entre los estudiantes de enfermería.Método: se trata de un estudio transversal desarrollado en una universidad privada en la ciudad de Río de Janeiro, Brasil, con 161estudiantes que respondieron a un cuestionario autoadministrado que contiene información sociodemográfica, preguntas seleccionadasdel Alcohol Use Disorders Identification Test y otros aspectos relacionados con el consumo de bebidas alcohólicas. Resultados: alta proporción(67,7 %) de los estudiantes de enfermería entrevistados reportó ser consumidores de alcohol, y el 32,1 % de ellos estaban en laorgía de consumo estándar, y casi la mitad (45,9 %) de los consumidores están expuestos al riesgo de desarrollar problemas relacionadoscon el consumo de esta sustancia. Resultados: están preocupados por el consumo de bebidas alcohólicas de los estudiantes de enfermeríaque participaron en este estudio, ya que son los futuros profesionales que inevitablemente actúan como educadores y motivadorespara la adopción de conductas saludables en la población. Conclusión: por lo tanto, se necesitan políticas y programas para prevenir elconsumo excesivo de alcohol en esta población.

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Reflection impulsivity in adolescent cannabis users: a comparison with alcohol-using and non-substance-using adolescents

Cited by 104 publications

References 78 publications

Activation of cannabinoid system in anterior cingulate cortex and orbitofrontal cortex modulates cost-benefit decision making

Activation of cannabinoid system in anterior cingulate cortex and orbitofrontal cortex modulates cost-benefit decision making

Prediction of vocational participation and global role functioning in help-seeking young adults, from neurocognitive, demographic and clinical variables

Alcohol Consumption and Executive Functions in Adolescents: A Systematic Review

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