Reflectivity of the Outer Retina on Spectral-Domain Optical Coherence Tomography as a Predictor of Photoreceptor Cone Density

Flores, Mathieu; Debellemanière, Guillaume; Bully, Alois; mathieu, meillat; Tumahai, Perle; Delbosc, B.; Saleh, Maher

doi:10.1016/j.ajo.2015.06.008

Cited by 17 publications

(14 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A strong relationship was recently established between EZ reflectivity and cone density measured with a high-resolution adaptive optics camera in the same perifoveal area. 16,17 In the current study, in diabetic eyes with resolved DME, we observed a 20% decrease in EZ reflectivity compared to diabetic eyes with no history of DME. Furthermore, reflectivity in diabetic eyes without a history of DME was also lower than in control eyes.…”

Section: Discussionsupporting

confidence: 53%

“…[9][10][11][12] Most of these studies examined qualitative parameters such as the integrity of the photoreceptor inner segment-OS (IS/OS) junction band using optical coherence tomography (OCT). [12][13][14][15] Recently, we reported a quantitative approach for estimating outer retinal impairment by measuring the reflectivity of the ellipsoid zone (EZ) of the photoreceptor on spectral-domain (SD)-OCT. 16,17 Obtaining a quantitative assessment of photoreceptor layer integrity could be of great help in the management and understanding of DME and its long-term consequences. Therefore, the aim of this study was to estimate photoreceptor impairment after DME resolution by measuring EZ reflectivity on en face SD-OCT images and to compare the results with those of controls.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Retinal Reflectivity Measurement for Cone Impairment Estimation and Visual Assessment After Diabetic Macular Edema Resolution (RECOVER-DME)

Guyon

Elphege

Flores

et al. 2017

Invest. Ophthalmol. Vis. Sci.

Self Cite

View full text Add to dashboard Cite

DME significantly impacts the photoreceptor layer. This impairment can be estimated by measuring outer retinal reflectivity on OCT images after edema resorption. We also provide evidence that in diabetic eyes without a history of DME, there is early photoreceptor loss, or at least outer segment (OS) disorganization, in addition to the inner retinal degeneration reported previously. This suggests the neurodegenerative process in diabetes. This quantitative approach may help monitor neuroprotective strategies to rescue photoreceptor cells in diabetic eyes.

show abstract

Section: Discussionsupporting

confidence: 53%

mentioning

confidence: 99%

Retinal Reflectivity Measurement for Cone Impairment Estimation and Visual Assessment After Diabetic Macular Edema Resolution (RECOVER-DME)

Guyon

Elphege

Flores

et al. 2017

Invest. Ophthalmol. Vis. Sci.

Self Cite

View full text Add to dashboard Cite

show abstract

“…A quantitative approach makes it possible to detect more subtle retinal changes and may serve to requalify OCT results thought to be normal. In prior work, we showed that ellipsoid band hyporeflectivity was related to a dropout of cone density [29], which reached, on average, one-third of the parafoveal cone contingency [40]. Consequently, the cone loss secondary to RD may result not only in a visual acuity decrease [40], but also in distorted vision.…”

Section: Discussionmentioning

confidence: 99%

“…At the 6-month visit, the masked graders looked for retinal cysts, epiretinal membrane, choroidal folds, ORFs, remnant subretinal fluid, pigment retinal migrations, and macular hole. They also graded the reflectivity of the photoreceptor layer by classifying the reflectivity of the ellipsoid and interdigitation zones into two groups according to a previously described technique (i.e., normal or decreased hyporeflectivity [29] (Fig. 2) with a grey level cutoff of 170 (0 = black, –256 = white).…”

Section: Methodsmentioning

confidence: 99%

Impact of Metamorphopsia on Quality of Life after Successful Retinal Detachment Surgery

Saleh¹,

Gauthier²,

Delbosc³

et al. 2018

Ophthalmologica

Self Cite

View full text Add to dashboard Cite

Purpose: To determine the impact of metamorphopsia on quality of life after successful retinal detachment (RD) surgery and to determine which retinal changes are related to the most severe distortions. Design: This was a prospective, observational, consecutive study. Methods: The study included 58 eyes of 58 consecutive patients who underwent successful RD surgery. At 6 months postoperatively, the incidence and severity of metamorphopsia were assessed by a quality-of-life questionnaire. Microstructure retinal changes were studied with spectral domain optical coherence tomography (OCT). The questionnaire score was compared with pre- and postoperative OCT findings. Results: Overall, 20 patients (34.5%) had metamorphopsia. Outer retinal folds (ORFs) and the macular status before surgery, together with postoperative ORFs and decrease in ellipsoid and/or interdigitation photoreceptor zone reflectivity, were identified as risk factors of developing metamorphopsia (relative risk, 1.7–4.8). The most severe visual distortions were associated with ORFs. Conclusion: Metamorphopsia is a frequent occurrence after RD surgery and its impact on patients’ quality of life appears to be limited. While it may be difficult to prevent photoreceptor loss occurring after surgery, limiting postoperative ORFs may be helpful in reducing their incidence.

show abstract

“…Systemic lupus erythematosus 2,4,[83][84][85][86][87][88] Rheumatoid arthritis Sjogrens syndrome Antiphospholipid syndrome Osteoarthritis Dermatomyositis Juvenile idiopathic arthritis Psoriatic arthritis Chemotherapy-related arthropathy 89 Dermatological disorders 8 Porphyria cutanea tarda (unlicensed use) Discoid lupus Cutaneous sarcoidosis 90 Granuloma annulare 8 Lichen planus (erosive) 92 Cutaneous pseudolymphoma 93…”

Section: Rheumatological Disordersmentioning

confidence: 99%

Hydroxychloroquine retinopathy

Yusuf

Sharma

Luqmani

et al. 2017

Eye

213

189

View full text Add to dashboard Cite

Hydroxychloroquine (HCQ; Plaquenil) is used increasingly in the management of a variety of autoimmune disorders, with well established roles in dermatology and rheumatology and emerging roles in oncology. Hydroxychloroquine has demonstrated a survival benefit in patients with systemic lupus erythematosus; some clinicians advocate its use in all such patients. However, Hydroxychloroquine and chloroquine (CQ) have been associated with irreversible visual loss due to retinal toxicity. Hydroxychloroquine retinal toxicity is far more common than previously considered; an overall prevalence of 7.5% was identified in patients taking HCQ for greater than 5 years, rising to almost 20% after 20 years of treatment. This review aims to provide an update on HCQ/CQ retinopathy. We summarise emerging treatment indications and evidence of efficacy in systemic disease, risk factors for retinopathy, prevalence among HCQ users, diagnostic tests, and management of HCQ retinopathy. We highlight emerging risk factors such as tamoxifen use, and new guidance on safe dosing, reversing the previous recommendation to use ideal body weight, rather than actual body weight. We summarise uncertainties and the recommendations made by existing HCQ screening programmes. Asian patients with HCQ retinopathy may demonstrate an extramacular or pericentral pattern of disease; visual field testing and retinal imaging should include a wider field for screening in this group. HCQ is generally safe and effective for the treatment of systemic disease but because of the risk of HCQ retinal toxicity, modern screening methods and ideal dosing should be implemented. Guidelines regarding optimal dosing and screening regarding HCQ need to be more widely disseminated.

show abstract

Reflectivity of the Outer Retina on Spectral-Domain Optical Coherence Tomography as a Predictor of Photoreceptor Cone Density

Cited by 17 publications

References 29 publications

Retinal Reflectivity Measurement for Cone Impairment Estimation and Visual Assessment After Diabetic Macular Edema Resolution (RECOVER-DME)

Retinal Reflectivity Measurement for Cone Impairment Estimation and Visual Assessment After Diabetic Macular Edema Resolution (RECOVER-DME)

Impact of Metamorphopsia on Quality of Life after Successful Retinal Detachment Surgery

Hydroxychloroquine retinopathy

Contact Info

Product

Resources

About