Reflektorische und lokal-irridativ induzierte Bronchokonstriktion

Lanser, K.; Kaukel, E.; Sill, V.

doi:10.1007/978-3-662-25411-0_29

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1979

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“…Analo gously to the findings in animals, it was also found that ipratropium bromide has a favorable effect against bronchospasm elicit ed in humans by acetylcholine inhalations [26,33], However, it had little or no effect with histamine or serotonin inhalation. Also, prior administration of ipratropium bromide was not completely effective in reducing the increase of airway resistance evoked by allergen challenge [4,7,14,18,19,26,27,34,35].…”

Section: Discussionmentioning

confidence: 99%

Immunological Release of Histamine from Human Lung

Morr¹

1979

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The experiments reported in this work have been performed to measure the effects of acetylcholine and the anticholinergic agent ipratropium bromide on the antigen-induced release of histamine from sensitized human lung in vitro. Primarily, ipratropium bromide did not have any effect, even at higher concentrations. Acetylcholine at a concentration of 1 × 10^-7M increased the antigen-induced release of histamine by approximately 41%. When the lung tissue was treated with ipratropium bromide before acetylcholine, the competitive inhibition of the cholinergic receptor almost completely abolished this acetylcholine-induced increase of histamine release. Therefore, in our opinion, anticholinergic agents are primarily useful in vagus-controlled chronic obstructive ventilatory disorders; they are of secondary importance in allergic bronchial asthma.

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Section: Discussionmentioning

confidence: 99%

Immunological Release of Histamine from Human Lung

Morr¹

1979

Respiration

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Reflektorische und lokal-irridativ induzierte Bronchokonstriktion

Cited by 1 publication

References 12 publications

Immunological Release of Histamine from Human Lung

Immunological Release of Histamine from Human Lung

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