Reflex changes in thermogenesis in the interscapular brown adipose tissue in response to thermal stimulation of the skin via sympathetic efferent nerves in anesthetized rats

Kurosawa, Mieko

doi:10.1016/0165-1838(91)90014-t

Cited by 12 publications

(4 citation statements)

References 22 publications

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“…The present study focused on the central efferent pathways mediating thermogenic, metabolic, and cardiovascular responses to environmental temperature changes. Skin cooling evoked significant increases in BAT SNA and thermogenesis, as reported previously (24), as well as in expired CO 2 and HR with no substantial changes in T brain and T rec , indicating that the observed increases in the thermogenic, metabolic, and cardiac parameters were induced by thermal afferent signals from the skin rather than the effect of temperature changes in body core parts or in the brain. Indeed, cooling of the brain, specifically the POA, is known to induce BAT thermogenesis (19).…”

Section: Discussionsupporting

confidence: 84%

Central efferent pathways mediating skin cooling-evoked sympathetic thermogenesis in brown adipose tissue

Nakamura

Morrison

2007

American Journal of Physiology-Regulatory, Integrative and Comp

210

280

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Control of thermoregulatory effectors by the autonomic nervous system is a critical component of rapid cold-defense responses, which are triggered by thermal information from the skin. However, the central autonomic mechanism driving thermoregulatory effector responses to skin thermal signals remains to be determined. Here, we examined the involvement of several autonomic brain regions in sympathetic thermogenic responses in brown adipose tissue (BAT) to skin cooling in urethane-chloralose-anesthetized rats by monitoring thermogenic [BAT sympathetic nerve activity (SNA) and BAT temperature], metabolic (expired CO(2)), and cardiovascular (arterial pressure and heart rate) parameters. Acute skin cooling, which did not reduce either rectal (core) or brain temperature, evoked increases in BAT SNA, BAT temperature, expired CO(2), and heart rate. Skin cooling-evoked thermogenic, metabolic, and heart rate responses were inhibited by bilateral microinjections of bicuculline (GABA(A) receptor antagonist) into the preoptic area (POA), by bilateral microinjections of muscimol (GABA(A) receptor agonist) into the dorsomedial hypothalamic nucleus (DMH), or by microinjection of muscimol, glycine, 8-OH-DPAT (5-HT(1A) receptor agonist), or kynurenate (nonselective antagonist for ionotropic excitatory amino acid receptors) into the rostral raphe pallidus nucleus (rRPa) but not by bilateral muscimol injections into the lateral/dorsolateral part or ventrolateral part of the caudal periaqueductal gray. These results implicate the POA, DMH, and rRPa in the central efferent pathways for thermogenic, metabolic, and cardiac responses to skin cooling, and suggest that these pathways can be modulated by serotonergic inputs to the medullary raphe.

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Section: Discussionsupporting

confidence: 84%

Central efferent pathways mediating skin cooling-evoked sympathetic thermogenesis in brown adipose tissue

Nakamura

Morrison

2007

American Journal of Physiology-Regulatory, Integrative and Comp

210

280

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“…To estimate cellular activity of BAT, electrophysiological method has been widely practiced by measuring efferent mass discharge rate of an intercostal nerve (Niijima et al 1984;Sakaguchi and Yamazaki 1988;Kurosawa 1991;Kawate et al 1994). However, qualitative information such as the shape and the duration of spikes has been ignored even though such experiments were carried out in whole-nerve method.…”

Section: Discussionmentioning

confidence: 99%

A neurophysiological evidence of capsaicin-sensitive nerve components innervating interscapular brown adipose tissue

Shinozaki

Shimizu

Shiina

et al. 2005

Autonomic Neuroscience

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“…Lumbar SND recordings provided information about sympathetic nerve outflow to the tail and to hindlimb skeletal muscle and skin vasculatures. IBAT nerve recordings were completed because activation of this nerve increases heat production through nonshivering thermogenesis (10,11,13,29).…”

Section: General Procedures the Institutional Animal Care Andmentioning

confidence: 99%

“…IL-1␤ administration increases internal body temperature (31)(32)(33) and produces physiological responses that are consistent with increasing internal body temperature, including increased oxygen consumption (4), increased brown adipose tissue blood flow (4), and reduced firing rate of warm-sensitive neurons (44,48) and increased firing rate of cold-sensitive neurons in the preoptic area of the anterior hypothalamus (48). In contrast, intravenous IL-1␤ administration does not increase IBAT SND in chloralose-anesthetized rats (21), despite the fact that activation of this nerve enhances heat production through nonshivering thermogenesis (10,11,13,29). However, increases in IBAT SND to mild hypothermia are significantly higher in IL-1␤-treated rats compared with saline-treated rats (21), demonstrating that IL-1␤ pretreatment sensitizes IBAT SND responses to acute cold stress.…”

mentioning

confidence: 99%

Altered frequency responses of sympathetic nerve discharge bursts after IL-1β and mild hypothermia

Kenney

Blecha²,

Fels³

et al. 2002

Journal of Applied Physiology

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Although interleukin-1beta (IL-1beta) administration produces nonuniform changes in the level of sympathetic nerve discharge (SND), the effect of IL-1beta on the frequency-domain relationships between discharges in different sympathetic nerves is not known. Autospectral and coherence analyses were used to determine the effect of IL-1beta and mild hypothermia (60 min after IL-1beta, colonic temperature from 38 degrees C to 36 degrees C) on the relationships between renal-interscapular brown adipose tissue (IBAT) and splenic-lumbar sympathetic nerve discharges in chloralose-anesthetized rats. The following observations were made. 1) IL-1beta did not alter renal-IBAT coherence values in the 0- to 2-Hz frequency band or at the cardiac frequency (CF). 2) Peak coherence values relating splenic-lumbar discharges at the CF were significantly increased after IL-1beta and during hypothermia. 3) Hypothermia after IL-1beta significantly reduced the coupling (0-2 Hz and CF) between renal-IBAT but not splenic-lumbar SND bursts. 4) Combining IL-1beta and mild hypothermia had a greater effect on renal-IBAT SND coherence values than did mild hypothermia alone. These data demonstrate functional plasticity in sympathetic neural circuits and suggest complex relationships between immune products and SND regulation.

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Reflex changes in thermogenesis in the interscapular brown adipose tissue in response to thermal stimulation of the skin via sympathetic efferent nerves in anesthetized rats

Cited by 12 publications

References 22 publications

Central efferent pathways mediating skin cooling-evoked sympathetic thermogenesis in brown adipose tissue

Central efferent pathways mediating skin cooling-evoked sympathetic thermogenesis in brown adipose tissue

A neurophysiological evidence of capsaicin-sensitive nerve components innervating interscapular brown adipose tissue

Altered frequency responses of sympathetic nerve discharge bursts after IL-1β and mild hypothermia

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