Reflux and sex

Nusrat, Salman; Bielefeldt, Klaus

doi:10.1097/meg.0b013e32834f6baa

Cited by 19 publications

(8 citation statements)

References 297 publications

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“…The percentage of patients with severe esophagitis of grades C and D was 14.7%, which was higher than the percentages in other studies performed in Japan, but did not differ significantly from those in previous Japanese studies focusing on elderly females [3,4,5,6,7,43,44,45,46], although the prevalence of severe esophagitis in females was the same as that in males in Western countries [47]. The present study further indicated that the risk factors for an increase in severe reflux esophagitis of grades C and D in aged females were lumbar kyphosis, hiatus hernia, negative H. pylori infection status, short height and high age, which were compatible with previous reports [3,4,5,8,9].…”

Section: Discussioncontrasting

confidence: 46%

Risk Factors for Resistance to Proton Pump Inhibitor Maintenance Therapy for Reflux Esophagitis in Japanese Women over 60 Years

et al. 2012

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Aim: The aim of this study was to evaluate risk factors for proton pump inhibitor (PPI) resistance in older Japanese female patients with reflux esophagitis evaluated by physicians. Methods: The study included 462 Japanese female patients aged over 60 years with reflux esophagitis who received PPI maintenance therapy for more than 6 months. Results: The characteristics of all 462 patients were: age: 76.4 ± 7.6 years, height: 147.2 ± 6.1 cm, weight: 49.9 ± 8.4 kg and body mass index: 24.0 ± 3.5. The reflux esophagitis grades were A in 69.5%, B in 15.8%, C in 9.1% and D in 5.6%. Helicobacter pylori was positive in 60.6%. Regarding PPI maintenance therapy for clinical symptoms evaluated by the attending physicians, 66.7% were ‘good control’, 26.8% were ‘reasonable control’ and 6.5% were ‘bad control: resistant’. PPI maintenance therapy was less effective in patients with more severe reflux esophagitis of grades C and D (OR: 0.027; 95% CI: 0.010–0.077) and negative H. pylori infection status (OR: 4.470; 95% CI: 1.631–12.247). Lumbar kyphosis and hiatus hernia were risk factors for severity grading of reflux esophagitis. Conclusions: PPI maintenance therapy evaluated by attending physicians indicated that reflux esophagitis severity and negative H. pylori status were risk factors for treatment resistance.

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Section: Discussioncontrasting

confidence: 46%

Risk Factors for Resistance to Proton Pump Inhibitor Maintenance Therapy for Reflux Esophagitis in Japanese Women over 60 Years

et al. 2012

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“…The current evidence on the association between gender and GERD symptoms is mixed, but the majority of studies have not shown any association [65]. However, in most studies with endoscopy, non-erosive GERD have been more common in women [66], whereas erosive esophagitis have been more common in men [65]–[67].…”

Section: Discussionmentioning

confidence: 99%

“…However, in most studies with endoscopy, non-erosive GERD have been more common in women [66], whereas erosive esophagitis have been more common in men [65]–[67]. The reported prevalence of symptoms and histological damage related to GERD varies across ethnic/racial groups [68], [69].…”

Section: Discussionmentioning

confidence: 99%

Determinants of Gastroesophageal Reflux Disease, Including Hookah Smoking and Opium Use– A Cross-Sectional Analysis of 50,000 Individuals

et al. 2014

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BackgroundGastroesophageal reflux disease (GERD) is a common cause of discomfort and morbidity worldwide. However, information on determinants of GERD from large-scale studies in low- to medium-income countries is limited. We investigated the factors associated with different measures of GERD symptoms, including frequency, patient-perceived severity, and onset time.MethodsWe performed a cross-sectional analysis of the baseline data from a population-based cohort study of ∼50,000 individuals in in Golestan Province, Iran. GERD symptoms in this study included regurgitation and/or heartburn.ResultsApproximately 20% of participants reported at least weekly symptoms. Daily symptoms were less commonly reported by men, those of Turkmen ethnicity, and nass chewers. On the other hand, age, body mass index, alcohol drinking, cigarette smoking, opium use, lower socioeconomic status, and lower physical activity were associated with daily symptoms. Most of these factors showed similar associations with severe symptoms. Women with higher BMI and waist to hip ratio were more likely to report frequent and severe GERD symptoms. Hookah smoking (OR 1.34, 95% CI 1.02–1.75) and opium use (OR 1.70, 95% CI 1.55–1.87) were associated with severe symptoms, whereas nass chewing had an inverse association (OR 0.87, 95% CI 0.76–0.99). After exclusion of cigarette smokers, hookah smoking was still positively associated and nass chewing was inversely associated with GERD symptoms (all frequencies combined).ConclusionGERD is common in this population. The associations of hookah and opium use and inverse association of nass use with GERD symptoms are reported for the first time. Further studies are required to investigate the nature of these associations. Other determinants of GERD were mostly comparable to those reported elsewhere.

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“…Second, only about one-third of the MS patients with dysphagia complained of esophageal symptoms such as heartburn or odynophagia. Lastly, reflux symptoms or a diagnosis of GERD, the most common cause of esophageal dysphagia, were reported by MS patients at rates similar to those seen in the general population [28]. …”

Section: Discussionmentioning

confidence: 99%

Adding to the Burden: Gastrointestinal Symptoms and Syndromes in Multiple Sclerosis

Levinthal

Rahman

Nusrat

et al. 2013

Multiple Sclerosis International

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Background. Multiple sclerosis (MS) patients often suffer from gastrointestinal (GI) symptoms. However, the full extent and prevalence of such symptoms are not clearly established. Thus, we sought to define the prevalence of GI symptoms and syndromes in those with MS. Methods. 218 MS patients completed self-reported demographic and clinical data questionnaires as well as several standardized surveys probing MS severity and GI health. Results. Nearly two thirds (65.6%) of patients endorsed at least one persistent GI symptom. Constipation (36.6%), dysphagia (21.1%), and fecal incontinence (15.1%) were common. Surprisingly, nearly 30% (28.4%) of the patients reported dyspeptic symptoms. Using validated diagnostic algorithms, patients met criteria for functional dysphagia (14.7%), functional dyspepsia (16.5%), functional constipation (31.7%), and IBS (19.3%), among others. Functional dysphagia, functional dyspepsia, and IBS were significantly more common in those with self-identified mood disorders. Conclusions. Constipation, fecal incontinence, and dysphagia are indeed frequent symptoms seen in MS patients. We also noted a ~30% prevalence of dyspepsia in this population. The mechanisms driving this association are not clear and require further study. However, due to this high prevalence, dyspeptic symptoms should be incorporated into the routine assessment of MS patients and, if found, may warrant collaborative referral with a GI specialist.

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Reflux and sex

Cited by 19 publications

References 297 publications

Risk Factors for Resistance to Proton Pump Inhibitor Maintenance Therapy for Reflux Esophagitis in Japanese Women over 60 Years

Risk Factors for Resistance to Proton Pump Inhibitor Maintenance Therapy for Reflux Esophagitis in Japanese Women over 60 Years

Determinants of Gastroesophageal Reflux Disease, Including Hookah Smoking and Opium Use– A Cross-Sectional Analysis of 50,000 Individuals

Adding to the Burden: Gastrointestinal Symptoms and Syndromes in Multiple Sclerosis

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